Repeated Administration of the Cannabinoid WIN Alters the Isoflurane-Sparing Effect of Morphine and Dexmedetomidine
The impacts of morphine and dexmedetomidine on the MAC of isoflurane were studied in rats constantly medicated with the cannabinoid WIN 55,212-2. Methods: Prior to the administration of morphine, the MAC was measured in both untreated rats (MAC <sub>(ISO)</sub>) and those treated with a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/10/5/310 |
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| author | José Antonio Ibancovichi Julio Raúl Chávez-Monteagudo Pedro Sánchez-Aparicio Marco Antonio De Paz-Campos |
| author_facet | José Antonio Ibancovichi Julio Raúl Chávez-Monteagudo Pedro Sánchez-Aparicio Marco Antonio De Paz-Campos |
| author_sort | José Antonio Ibancovichi |
| collection | DOAJ |
| description | The impacts of morphine and dexmedetomidine on the MAC of isoflurane were studied in rats constantly medicated with the cannabinoid WIN 55,212-2. Methods: Prior to the administration of morphine, the MAC was measured in both untreated rats (MAC <sub>(ISO)</sub>) and those treated with a cannabinoid (MAC <sub>(ISO + CANN)</sub>). The effects of morphine (MAC <sub>(ISO + MOR)</sub>) and dexmedetomidine (MAC <sub>(ISO + DEX)</sub>) on untreated rats and rats treated for 21 days with the cannabinoids (MAC <sub>(ISO + CANN + MOR)</sub>) and (MAC <sub>(ISO + CANN + DEX</sub>) were also studied. Results: MAC <sub>(ISO)</sub> was 1.32 ± 0.06, and MAC <sub>(ISO + CANN)</sub> was 1.69 ± 0.09. MAC <sub>(ISO + MOR)</sub> was 0.97 ± 0.02 (26% less than MAC <sub>(ISO)</sub>). MAC <sub>(ISO + CANN + MOR)</sub> was 1.55 ± 0.08 (8% less than MAC <sub>(ISO + CANN)</sub>), MAC <sub>(ISO + DEX)</sub> was 0.68 ± 0.10 (48% less than MAC <sub>(ISO)</sub>), and MAC <sub>(ISO + CANN + DEX)</sub> was 0.67 ± 0.08 (60% less than MAC <sub>(ISO + CANN)</sub>). Conclusions: Medication with a cannabinoid for 21 days augmented the MAC of isoflurane. The sparing effect of morphine on isoflurane is lower in rats constantly medicated with a cannabinoid. The sparing effect of dexmedetomidine on the minimum alveolar concentration of isoflurane is greater in rats repeatedly medicated with a cannabinoid. |
| first_indexed | 2024-03-11T03:14:51Z |
| format | Article |
| id | doaj.art-dd54779540c14056897a95e72a8cac63 |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-11T03:14:51Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-dd54779540c14056897a95e72a8cac632023-11-18T03:37:08ZengMDPI AGVeterinary Sciences2306-73812023-04-0110531010.3390/vetsci10050310Repeated Administration of the Cannabinoid WIN Alters the Isoflurane-Sparing Effect of Morphine and DexmedetomidineJosé Antonio Ibancovichi0Julio Raúl Chávez-Monteagudo1Pedro Sánchez-Aparicio2Marco Antonio De Paz-Campos3Departamento de Anestesiología y Analgesia, Facultad de Medicina Veterinaria, Universidad Autónoma del Estado de México, UAEM, Toluca 50000, MexicoDepartamento de Ciencias Pecuarias, Facultad de Estudios Superiores Cuautitlán, Hospital de Pequeñas Especies, Universidad Nacional Autónoma de México, UNAM, Cuautitlán Izcalli 54740, MexicoDepartamento de Farmacología, Facultad de Medicina Veterinaria, Universidad Autónoma del Estado de México, UAEM, Toluca 50000, MexicoDepartamento de Ciencias Biológicas, Facultad de Estudios Superiores Cuautitlán, Hospital de Pequeñas Especies, Universidad Nacional Autónoma de México, UNAM, Cuautitlán Izcalli 54740, MexicoThe impacts of morphine and dexmedetomidine on the MAC of isoflurane were studied in rats constantly medicated with the cannabinoid WIN 55,212-2. Methods: Prior to the administration of morphine, the MAC was measured in both untreated rats (MAC <sub>(ISO)</sub>) and those treated with a cannabinoid (MAC <sub>(ISO + CANN)</sub>). The effects of morphine (MAC <sub>(ISO + MOR)</sub>) and dexmedetomidine (MAC <sub>(ISO + DEX)</sub>) on untreated rats and rats treated for 21 days with the cannabinoids (MAC <sub>(ISO + CANN + MOR)</sub>) and (MAC <sub>(ISO + CANN + DEX</sub>) were also studied. Results: MAC <sub>(ISO)</sub> was 1.32 ± 0.06, and MAC <sub>(ISO + CANN)</sub> was 1.69 ± 0.09. MAC <sub>(ISO + MOR)</sub> was 0.97 ± 0.02 (26% less than MAC <sub>(ISO)</sub>). MAC <sub>(ISO + CANN + MOR)</sub> was 1.55 ± 0.08 (8% less than MAC <sub>(ISO + CANN)</sub>), MAC <sub>(ISO + DEX)</sub> was 0.68 ± 0.10 (48% less than MAC <sub>(ISO)</sub>), and MAC <sub>(ISO + CANN + DEX)</sub> was 0.67 ± 0.08 (60% less than MAC <sub>(ISO + CANN)</sub>). Conclusions: Medication with a cannabinoid for 21 days augmented the MAC of isoflurane. The sparing effect of morphine on isoflurane is lower in rats constantly medicated with a cannabinoid. The sparing effect of dexmedetomidine on the minimum alveolar concentration of isoflurane is greater in rats repeatedly medicated with a cannabinoid.https://www.mdpi.com/2306-7381/10/5/310minimum alveolar concentration of isofluranedexmedetomidinemorphinecannabinoid WIN 55,212-2rats |
| spellingShingle | José Antonio Ibancovichi Julio Raúl Chávez-Monteagudo Pedro Sánchez-Aparicio Marco Antonio De Paz-Campos Repeated Administration of the Cannabinoid WIN Alters the Isoflurane-Sparing Effect of Morphine and Dexmedetomidine Veterinary Sciences minimum alveolar concentration of isoflurane dexmedetomidine morphine cannabinoid WIN 55,212-2 rats |
| title | Repeated Administration of the Cannabinoid WIN Alters the Isoflurane-Sparing Effect of Morphine and Dexmedetomidine |
| title_full | Repeated Administration of the Cannabinoid WIN Alters the Isoflurane-Sparing Effect of Morphine and Dexmedetomidine |
| title_fullStr | Repeated Administration of the Cannabinoid WIN Alters the Isoflurane-Sparing Effect of Morphine and Dexmedetomidine |
| title_full_unstemmed | Repeated Administration of the Cannabinoid WIN Alters the Isoflurane-Sparing Effect of Morphine and Dexmedetomidine |
| title_short | Repeated Administration of the Cannabinoid WIN Alters the Isoflurane-Sparing Effect of Morphine and Dexmedetomidine |
| title_sort | repeated administration of the cannabinoid win alters the isoflurane sparing effect of morphine and dexmedetomidine |
| topic | minimum alveolar concentration of isoflurane dexmedetomidine morphine cannabinoid WIN 55,212-2 rats |
| url | https://www.mdpi.com/2306-7381/10/5/310 |
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