The Complete Genome Sequence of the Fish Pathogen Tenacibaculum maritimum Provides Insights into Virulence Mechanisms
Tenacibaculum maritimum is a devastating bacterial pathogen of wild and farmed marine fish with a broad host range and a worldwide distribution. We report here the complete genome sequence of the T. maritimum type strain NCIMB 2154T. The genome consists of a 3,435,971-base pair circular chromosome w...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-08-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fmicb.2017.01542/full |
| _version_ | 1819295089879416832 |
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| author | David Pérez-Pascual Aurelie Lunazzi Ghislaine Magdelenat Zoe Rouy Alain Roulet Alain Roulet Celine Lopez-Roques Celine Lopez-Roques Robert Larocque Tristan Barbeyron Angélique Gobet Gurvan Michel Jean-François Bernardet Eric Duchaud |
| author_facet | David Pérez-Pascual Aurelie Lunazzi Ghislaine Magdelenat Zoe Rouy Alain Roulet Alain Roulet Celine Lopez-Roques Celine Lopez-Roques Robert Larocque Tristan Barbeyron Angélique Gobet Gurvan Michel Jean-François Bernardet Eric Duchaud |
| author_sort | David Pérez-Pascual |
| collection | DOAJ |
| description | Tenacibaculum maritimum is a devastating bacterial pathogen of wild and farmed marine fish with a broad host range and a worldwide distribution. We report here the complete genome sequence of the T. maritimum type strain NCIMB 2154T. The genome consists of a 3,435,971-base pair circular chromosome with 2,866 predicted protein-coding genes. Genes encoding the biosynthesis of exopolysaccharides, the type IX secretion system, iron uptake systems, adhesins, hemolysins, proteases, and glycoside hydrolases were identified. They are likely involved in the virulence process including immune escape, invasion, colonization, destruction of host tissues, and nutrient scavenging. Among the predicted virulence factors, type IX secretion-mediated and cell-surface exposed proteins were identified including an atypical sialidase, a sphingomyelinase and a chondroitin AC lyase which activities were demonstrated in vitro. |
| first_indexed | 2024-12-24T04:36:41Z |
| format | Article |
| id | doaj.art-dd5479c30b684772a5ce61bcc2c91287 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-24T04:36:41Z |
| publishDate | 2017-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-dd5479c30b684772a5ce61bcc2c912872022-12-21T17:15:09ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2017-08-01810.3389/fmicb.2017.01542263568The Complete Genome Sequence of the Fish Pathogen Tenacibaculum maritimum Provides Insights into Virulence MechanismsDavid Pérez-Pascual0Aurelie Lunazzi1Ghislaine Magdelenat2Zoe Rouy3Alain Roulet4Alain Roulet5Celine Lopez-Roques6Celine Lopez-Roques7Robert Larocque8Tristan Barbeyron9Angélique Gobet10Gurvan Michel11Jean-François Bernardet12Eric Duchaud13Virologie et Immunologie Moléculaires, Institut National de la Recherche Agronomique, Université Paris-SaclayJouy-en-Josas, FranceVirologie et Immunologie Moléculaires, Institut National de la Recherche Agronomique, Université Paris-SaclayJouy-en-Josas, FranceCommissariat à l’Énergie Atomique et aux Énergies Alternatives, Institut de Génomique, GenoscopeEvry, FranceLaboratoire d’Analyses Bioinformatiques en Génomique et Métabolisme, Centre National de la Recherche Scientifique (UMR-8030), Commissariat à l’Énergie Atomique et aux Énergies Alternatives, Institut de Génomique, GenoscopeEvry, FranceGenotoul Genome & Transcriptome (GeT-PlaGe), Institut National de la Recherche AgronomiqueCastanet-Tolosan, FranceInstitut National de la Recherche Agronomique (UAR1209)Castanet-Tolosan, FranceGenotoul Genome & Transcriptome (GeT-PlaGe), Institut National de la Recherche AgronomiqueCastanet-Tolosan, FranceInstitut National de la Recherche Agronomique (UAR1209)Castanet-Tolosan, FranceLaboratoire de Biologie Intégrative des Modèles Marins (UMR 8227), Centre National de la Recherche Scientifique, Université Pierre et Marie Curie, Station Biologique de Roscoff, Sorbonne UniversitésRoscoff, FranceLaboratoire de Biologie Intégrative des Modèles Marins (UMR 8227), Centre National de la Recherche Scientifique, Université Pierre et Marie Curie, Station Biologique de Roscoff, Sorbonne UniversitésRoscoff, FranceLaboratoire de Biologie Intégrative des Modèles Marins (UMR 8227), Centre National de la Recherche Scientifique, Université Pierre et Marie Curie, Station Biologique de Roscoff, Sorbonne UniversitésRoscoff, FranceLaboratoire de Biologie Intégrative des Modèles Marins (UMR 8227), Centre National de la Recherche Scientifique, Université Pierre et Marie Curie, Station Biologique de Roscoff, Sorbonne UniversitésRoscoff, FranceVirologie et Immunologie Moléculaires, Institut National de la Recherche Agronomique, Université Paris-SaclayJouy-en-Josas, FranceVirologie et Immunologie Moléculaires, Institut National de la Recherche Agronomique, Université Paris-SaclayJouy-en-Josas, FranceTenacibaculum maritimum is a devastating bacterial pathogen of wild and farmed marine fish with a broad host range and a worldwide distribution. We report here the complete genome sequence of the T. maritimum type strain NCIMB 2154T. The genome consists of a 3,435,971-base pair circular chromosome with 2,866 predicted protein-coding genes. Genes encoding the biosynthesis of exopolysaccharides, the type IX secretion system, iron uptake systems, adhesins, hemolysins, proteases, and glycoside hydrolases were identified. They are likely involved in the virulence process including immune escape, invasion, colonization, destruction of host tissues, and nutrient scavenging. Among the predicted virulence factors, type IX secretion-mediated and cell-surface exposed proteins were identified including an atypical sialidase, a sphingomyelinase and a chondroitin AC lyase which activities were demonstrated in vitro.http://journal.frontiersin.org/article/10.3389/fmicb.2017.01542/fullTenacibaculum maritimumfish pathogenvirulence factorsgenometoxins |
| spellingShingle | David Pérez-Pascual Aurelie Lunazzi Ghislaine Magdelenat Zoe Rouy Alain Roulet Alain Roulet Celine Lopez-Roques Celine Lopez-Roques Robert Larocque Tristan Barbeyron Angélique Gobet Gurvan Michel Jean-François Bernardet Eric Duchaud The Complete Genome Sequence of the Fish Pathogen Tenacibaculum maritimum Provides Insights into Virulence Mechanisms Frontiers in Microbiology Tenacibaculum maritimum fish pathogen virulence factors genome toxins |
| title | The Complete Genome Sequence of the Fish Pathogen Tenacibaculum maritimum Provides Insights into Virulence Mechanisms |
| title_full | The Complete Genome Sequence of the Fish Pathogen Tenacibaculum maritimum Provides Insights into Virulence Mechanisms |
| title_fullStr | The Complete Genome Sequence of the Fish Pathogen Tenacibaculum maritimum Provides Insights into Virulence Mechanisms |
| title_full_unstemmed | The Complete Genome Sequence of the Fish Pathogen Tenacibaculum maritimum Provides Insights into Virulence Mechanisms |
| title_short | The Complete Genome Sequence of the Fish Pathogen Tenacibaculum maritimum Provides Insights into Virulence Mechanisms |
| title_sort | complete genome sequence of the fish pathogen tenacibaculum maritimum provides insights into virulence mechanisms |
| topic | Tenacibaculum maritimum fish pathogen virulence factors genome toxins |
| url | http://journal.frontiersin.org/article/10.3389/fmicb.2017.01542/full |
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