Anticancer Screening of Various Seed Extract of Cardiospermum halicacabum on Human Colorectal, Skin and Breast Cancer Cell Lines
Background: In the modern lifestyle, the increase in cancer and related chronic disorders is a major public health problem. In spite of different methods used for the treatment of these conditions, natural medicines have high demands due to their significant effects as immune enhancement and therape...
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| Format: | Article |
| Language: | English |
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Kaviani Breast Disease Institute
2015-08-01
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| Series: | Archives of Breast Cancer |
| Subjects: | |
| Online Access: | https://archbreastcancer.com/index.php/abc/article/view/42 |
| _version_ | 1818555769086279680 |
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| author | Behzad Mohaddesi Ashvin Dudhrejiya Navin R. Sheth |
| author_facet | Behzad Mohaddesi Ashvin Dudhrejiya Navin R. Sheth |
| author_sort | Behzad Mohaddesi |
| collection | DOAJ |
| description | Background: In the modern lifestyle, the increase in cancer and related chronic disorders is a major public health problem. In spite of different methods used for the treatment of these conditions, natural medicines have high demands due to their significant effects as immune enhancement and therapeutic agents and fewer side effects in comparison with other treatment methods. Hence, this study was undertaken to evaluate the cytotoxic effect of cardiospermum halicacabum Linn. seeds, based on traditional claims.
Methods: A Soxhlet extractor was used to obtain different extracts from seeds of C. halicacabum Linn. Sulforhodamine B colorimetric (SRB) assay used for the evaluation of the cytotoxic effect of the various extracts on HT-29, HCT-15 colon carcinoma, SK-MEL-2 skin carcinoma, and MCF-7 breast carcinoma. The results were compared against Doxorubicin as a standard drug.
Results: The results of the present study showed the potent cytotoxic activity of n-hexane extract of seeds of C. halicacabum Linn. against the MCF-7 breast cancer cell line with 50% growth inhibition value (GI50) of 12.8 ?g/ml but other extracts showed poor activity in other tested cell lines.
Conclusions: The results indicated the potential medicinal value of C. halicacabum Linn. seeds oil with the highest extractive yield as an antineoplastic agent. However, further studies are needed for the isolation of the active anticancer compounds and evaluating the mechanism of action of the responsible compound. |
| first_indexed | 2024-12-12T09:57:54Z |
| format | Article |
| id | doaj.art-dd5599fe11b7444eafc290a3f80a55ec |
| institution | Directory Open Access Journal |
| issn | 2383-0433 |
| language | English |
| last_indexed | 2024-12-12T09:57:54Z |
| publishDate | 2015-08-01 |
| publisher | Kaviani Breast Disease Institute |
| record_format | Article |
| series | Archives of Breast Cancer |
| spelling | doaj.art-dd5599fe11b7444eafc290a3f80a55ec2022-12-22T00:28:05ZengKaviani Breast Disease InstituteArchives of Breast Cancer2383-04332015-08-012310.19187/abc.20152391-9542Anticancer Screening of Various Seed Extract of Cardiospermum halicacabum on Human Colorectal, Skin and Breast Cancer Cell LinesBehzad Mohaddesi0Ashvin Dudhrejiya1Navin R. Sheth2Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, Gujarat, IndiaB.K. Mody Government Pharmacy College, Rajkot, Gujarat, IndiaDepartment of Pharmaceutical Sciences, Saurashtra University, Rajkot, Gujarat, IndiaBackground: In the modern lifestyle, the increase in cancer and related chronic disorders is a major public health problem. In spite of different methods used for the treatment of these conditions, natural medicines have high demands due to their significant effects as immune enhancement and therapeutic agents and fewer side effects in comparison with other treatment methods. Hence, this study was undertaken to evaluate the cytotoxic effect of cardiospermum halicacabum Linn. seeds, based on traditional claims. Methods: A Soxhlet extractor was used to obtain different extracts from seeds of C. halicacabum Linn. Sulforhodamine B colorimetric (SRB) assay used for the evaluation of the cytotoxic effect of the various extracts on HT-29, HCT-15 colon carcinoma, SK-MEL-2 skin carcinoma, and MCF-7 breast carcinoma. The results were compared against Doxorubicin as a standard drug. Results: The results of the present study showed the potent cytotoxic activity of n-hexane extract of seeds of C. halicacabum Linn. against the MCF-7 breast cancer cell line with 50% growth inhibition value (GI50) of 12.8 ?g/ml but other extracts showed poor activity in other tested cell lines. Conclusions: The results indicated the potential medicinal value of C. halicacabum Linn. seeds oil with the highest extractive yield as an antineoplastic agent. However, further studies are needed for the isolation of the active anticancer compounds and evaluating the mechanism of action of the responsible compound.https://archbreastcancer.com/index.php/abc/article/view/42Skin cancercytotoxicitybreast cancercolon cancercardiospermum halicacabum |
| spellingShingle | Behzad Mohaddesi Ashvin Dudhrejiya Navin R. Sheth Anticancer Screening of Various Seed Extract of Cardiospermum halicacabum on Human Colorectal, Skin and Breast Cancer Cell Lines Archives of Breast Cancer Skin cancer cytotoxicity breast cancer colon cancer cardiospermum halicacabum |
| title | Anticancer Screening of Various Seed Extract of Cardiospermum halicacabum on Human Colorectal, Skin and Breast Cancer Cell Lines |
| title_full | Anticancer Screening of Various Seed Extract of Cardiospermum halicacabum on Human Colorectal, Skin and Breast Cancer Cell Lines |
| title_fullStr | Anticancer Screening of Various Seed Extract of Cardiospermum halicacabum on Human Colorectal, Skin and Breast Cancer Cell Lines |
| title_full_unstemmed | Anticancer Screening of Various Seed Extract of Cardiospermum halicacabum on Human Colorectal, Skin and Breast Cancer Cell Lines |
| title_short | Anticancer Screening of Various Seed Extract of Cardiospermum halicacabum on Human Colorectal, Skin and Breast Cancer Cell Lines |
| title_sort | anticancer screening of various seed extract of cardiospermum halicacabum on human colorectal skin and breast cancer cell lines |
| topic | Skin cancer cytotoxicity breast cancer colon cancer cardiospermum halicacabum |
| url | https://archbreastcancer.com/index.php/abc/article/view/42 |
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