An Optimization Procedure for Preparing Aqueous CAR/HP-CD Aggregate Dispersions
β-Carotene is a very important molecule for human health. It finds a large application in the food industry, especially for the development of functional foods and dietary supplements. However, β-carotene is an unstable compound and is sensitive to light, temperature, and oxygen. To overcome those l...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/24/7562 |
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| author | Enrika Celitan Ruta Gruskiene Jolanta Sereikaite |
| author_facet | Enrika Celitan Ruta Gruskiene Jolanta Sereikaite |
| author_sort | Enrika Celitan |
| collection | DOAJ |
| description | β-Carotene is a very important molecule for human health. It finds a large application in the food industry, especially for the development of functional foods and dietary supplements. However, β-carotene is an unstable compound and is sensitive to light, temperature, and oxygen. To overcome those limitations, various delivery systems were developed. The inclusion of β-carotene by cyclodextrin aggregates is attractive due to non-toxicity, low hygroscopicity, stability, and the inexpensiveness of cyclodextrins. In this study, β-carotene/2-hydroxypropyl-β-cyclodextrin aggregates were prepared based on the procedure of the addition of β-carotene in an organic solvent to the hot water dispersion of 2-hydroxypropyl-β-cyclodextrin and the following instant evaporation of the organic solvent. The best conditions for the aggregate preparation were found to be as follows: 25% concentration of 2-hydroxypropyl-β-cyclodextrin in water, 65 °C temperature, and acetone for β-carotene dissolution. The efficiency of entrapping was equal to 88%. The procedure is attractive due to the short time of the aggregate preparation. |
| first_indexed | 2024-03-10T03:29:44Z |
| format | Article |
| id | doaj.art-dd5858161d654538b101c768967ddcf1 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T03:29:44Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-dd5858161d654538b101c768967ddcf12023-11-23T09:45:55ZengMDPI AGMolecules1420-30492021-12-012624756210.3390/molecules26247562An Optimization Procedure for Preparing Aqueous CAR/HP-CD Aggregate DispersionsEnrika Celitan0Ruta Gruskiene1Jolanta Sereikaite2Department of Chemistry and Bioengineering, Vilnius Gediminas Technical University, LT-10223 Vilnius, LithuaniaDepartment of Chemistry and Bioengineering, Vilnius Gediminas Technical University, LT-10223 Vilnius, LithuaniaDepartment of Chemistry and Bioengineering, Vilnius Gediminas Technical University, LT-10223 Vilnius, Lithuaniaβ-Carotene is a very important molecule for human health. It finds a large application in the food industry, especially for the development of functional foods and dietary supplements. However, β-carotene is an unstable compound and is sensitive to light, temperature, and oxygen. To overcome those limitations, various delivery systems were developed. The inclusion of β-carotene by cyclodextrin aggregates is attractive due to non-toxicity, low hygroscopicity, stability, and the inexpensiveness of cyclodextrins. In this study, β-carotene/2-hydroxypropyl-β-cyclodextrin aggregates were prepared based on the procedure of the addition of β-carotene in an organic solvent to the hot water dispersion of 2-hydroxypropyl-β-cyclodextrin and the following instant evaporation of the organic solvent. The best conditions for the aggregate preparation were found to be as follows: 25% concentration of 2-hydroxypropyl-β-cyclodextrin in water, 65 °C temperature, and acetone for β-carotene dissolution. The efficiency of entrapping was equal to 88%. The procedure is attractive due to the short time of the aggregate preparation.https://www.mdpi.com/1420-3049/26/24/7562β-carotene2-hydroxypropyl-β-cyclodextrinaggregateoptimization of procedureco-precipitation |
| spellingShingle | Enrika Celitan Ruta Gruskiene Jolanta Sereikaite An Optimization Procedure for Preparing Aqueous CAR/HP-CD Aggregate Dispersions Molecules β-carotene 2-hydroxypropyl-β-cyclodextrin aggregate optimization of procedure co-precipitation |
| title | An Optimization Procedure for Preparing Aqueous CAR/HP-CD Aggregate Dispersions |
| title_full | An Optimization Procedure for Preparing Aqueous CAR/HP-CD Aggregate Dispersions |
| title_fullStr | An Optimization Procedure for Preparing Aqueous CAR/HP-CD Aggregate Dispersions |
| title_full_unstemmed | An Optimization Procedure for Preparing Aqueous CAR/HP-CD Aggregate Dispersions |
| title_short | An Optimization Procedure for Preparing Aqueous CAR/HP-CD Aggregate Dispersions |
| title_sort | optimization procedure for preparing aqueous car hp cd aggregate dispersions |
| topic | β-carotene 2-hydroxypropyl-β-cyclodextrin aggregate optimization of procedure co-precipitation |
| url | https://www.mdpi.com/1420-3049/26/24/7562 |
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