The Prognostic Significance of <i>FKBP1A</i> and Its Related Immune Infiltration in Liver Hepatocellular Carcinoma
Liver hepatocellular carcinoma (LIHC) remains a global health challenge with poor prognosis and high mortality. <i>FKBP1A</i> was first discovered as a receptor for the immunosuppressant drug FK506 in immune cells and is critical for various tumors and cancers. However, the relationships...
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2022-10-01
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| Series: | International Journal of Molecular Sciences |
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| author | Zhongguang Li Ying Cui Qinchun Duan Jianfei Zhang Danyang Shao Xixi Cao Yuru Gao Shulin Wang Jiali Li Odell D. Jones Xinjuan Lei Liyang Wang Xin Zhou Mengmeng Xu Jianjie Ma Yingli Liu Xuehong Xu |
| author_facet | Zhongguang Li Ying Cui Qinchun Duan Jianfei Zhang Danyang Shao Xixi Cao Yuru Gao Shulin Wang Jiali Li Odell D. Jones Xinjuan Lei Liyang Wang Xin Zhou Mengmeng Xu Jianjie Ma Yingli Liu Xuehong Xu |
| author_sort | Zhongguang Li |
| collection | DOAJ |
| description | Liver hepatocellular carcinoma (LIHC) remains a global health challenge with poor prognosis and high mortality. <i>FKBP1A</i> was first discovered as a receptor for the immunosuppressant drug FK506 in immune cells and is critical for various tumors and cancers. However, the relationships between <i>FKBP1A</i> expression, cellular distribution, tumor immunity, and prognosis in LIHC remain unclear. Here, we investigated the expression level of <i>FKBP1A</i> and its prognostic value in LIHC via multiple datasets including ONCOMINE, TIMER, GEPIA, UALCAN, HCCDB, Kaplan–Meier plotter, LinkedOmics, and STRING. Human liver tissue microarray was employed to analyze the characteristics of FKBP1A protein including the expression level and pathological alteration in cellular distribution. <i>FKBP1A</i> expression was significantly higher in LIHC and correlated with tumor stage, grade and metastasis. The expression level of the FKBP1A protein was also increased in LIHC patients along with its accumulation in endoplasmic reticulum (ER). High <i>FKBP1A</i> expression was correlated with a poor survival rate in LIHC patients. The analysis of gene co-expression and the regulatory pathway network suggested that <i>FKBP1A</i> is mainly involved in protein synthesis, metabolism and the immune-related pathway. <i>FKBP1A</i> expression had a significantly positive association with the infiltration of hematopoietic immune cells including B cells, CD8<sup>+</sup> T cells, CD4<sup>+</sup> T cells, macrophages, neutrophils, and dendritic cells. Moreover, M2 macrophage infiltration was especially associated with a poor survival prognosis in LIHC. Furthermore, <i>FKBP1A</i> expression was significantly positively correlated with the expression of markers of M2 macrophages and immune checkpoint proteins such as <i>PD-L1</i>, <i>CTLA-4</i>, <i>LAG3</i> and <i>HAVCR2</i>. Our study demonstrated that <i>FKBP1A</i> could be a potential prognostic target involved in tumor immune cell infiltration in LIHC. |
| first_indexed | 2024-03-09T19:02:01Z |
| format | Article |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T19:02:01Z |
| publishDate | 2022-10-01 |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-dd597d995c18407dadac10cc753b89a72023-11-24T04:57:21ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-10-0123211279710.3390/ijms232112797The Prognostic Significance of <i>FKBP1A</i> and Its Related Immune Infiltration in Liver Hepatocellular CarcinomaZhongguang Li0Ying Cui1Qinchun Duan2Jianfei Zhang3Danyang Shao4Xixi Cao5Yuru Gao6Shulin Wang7Jiali Li8Odell D. Jones9Xinjuan Lei10Liyang Wang11Xin Zhou12Mengmeng Xu13Jianjie Ma14Yingli Liu15Xuehong Xu16Laboratory of Cell Biology, Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences, Xi’an 710062, ChinaLaboratory of Cell Biology, Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences, Xi’an 710062, ChinaLaboratory of Cell Biology, Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences, Xi’an 710062, ChinaLaboratory of Cell Biology, Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences, Xi’an 710062, ChinaLaboratory of Cell Biology, Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences, Xi’an 710062, ChinaLaboratory of Cell Biology, Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences, Xi’an 710062, ChinaLaboratory of Cell Biology, Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences, Xi’an 710062, ChinaLaboratory of Cell Biology, Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences, Xi’an 710062, ChinaDepartment of Internal Medicine, University Hospital Shaanxi Normal University, Xi’an 710062, ChinaUniversity Laboratory Animal Resources (ULAR), University of Pennsylvania School of Medicine, Philadelphia, PA 19144, USALaboratory of Cell Biology, Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences, Xi’an 710062, ChinaLaboratory of Cell Biology, Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences, Xi’an 710062, ChinaLaboratory of Cell Biology, Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences, Xi’an 710062, ChinaDepartment of Pediatrics, Columbia University, New York, NY 10032, USADepartment of Surgery, Davis Heart and Lung Research Institute, Ohio State University School of Medicine, Columbus, OH 43210, USADepartment of Internal Medicine, University Hospital Shaanxi Normal University, Xi’an 710062, ChinaLaboratory of Cell Biology, Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences, Xi’an 710062, ChinaLiver hepatocellular carcinoma (LIHC) remains a global health challenge with poor prognosis and high mortality. <i>FKBP1A</i> was first discovered as a receptor for the immunosuppressant drug FK506 in immune cells and is critical for various tumors and cancers. However, the relationships between <i>FKBP1A</i> expression, cellular distribution, tumor immunity, and prognosis in LIHC remain unclear. Here, we investigated the expression level of <i>FKBP1A</i> and its prognostic value in LIHC via multiple datasets including ONCOMINE, TIMER, GEPIA, UALCAN, HCCDB, Kaplan–Meier plotter, LinkedOmics, and STRING. Human liver tissue microarray was employed to analyze the characteristics of FKBP1A protein including the expression level and pathological alteration in cellular distribution. <i>FKBP1A</i> expression was significantly higher in LIHC and correlated with tumor stage, grade and metastasis. The expression level of the FKBP1A protein was also increased in LIHC patients along with its accumulation in endoplasmic reticulum (ER). High <i>FKBP1A</i> expression was correlated with a poor survival rate in LIHC patients. The analysis of gene co-expression and the regulatory pathway network suggested that <i>FKBP1A</i> is mainly involved in protein synthesis, metabolism and the immune-related pathway. <i>FKBP1A</i> expression had a significantly positive association with the infiltration of hematopoietic immune cells including B cells, CD8<sup>+</sup> T cells, CD4<sup>+</sup> T cells, macrophages, neutrophils, and dendritic cells. Moreover, M2 macrophage infiltration was especially associated with a poor survival prognosis in LIHC. Furthermore, <i>FKBP1A</i> expression was significantly positively correlated with the expression of markers of M2 macrophages and immune checkpoint proteins such as <i>PD-L1</i>, <i>CTLA-4</i>, <i>LAG3</i> and <i>HAVCR2</i>. Our study demonstrated that <i>FKBP1A</i> could be a potential prognostic target involved in tumor immune cell infiltration in LIHC.https://www.mdpi.com/1422-0067/23/21/12797<i>FKBP1A</i>hepatocellular carcinomabioinformatics analysisimmune infiltrationprognostic biomarker |
| spellingShingle | Zhongguang Li Ying Cui Qinchun Duan Jianfei Zhang Danyang Shao Xixi Cao Yuru Gao Shulin Wang Jiali Li Odell D. Jones Xinjuan Lei Liyang Wang Xin Zhou Mengmeng Xu Jianjie Ma Yingli Liu Xuehong Xu The Prognostic Significance of <i>FKBP1A</i> and Its Related Immune Infiltration in Liver Hepatocellular Carcinoma International Journal of Molecular Sciences <i>FKBP1A</i> hepatocellular carcinoma bioinformatics analysis immune infiltration prognostic biomarker |
| title | The Prognostic Significance of <i>FKBP1A</i> and Its Related Immune Infiltration in Liver Hepatocellular Carcinoma |
| title_full | The Prognostic Significance of <i>FKBP1A</i> and Its Related Immune Infiltration in Liver Hepatocellular Carcinoma |
| title_fullStr | The Prognostic Significance of <i>FKBP1A</i> and Its Related Immune Infiltration in Liver Hepatocellular Carcinoma |
| title_full_unstemmed | The Prognostic Significance of <i>FKBP1A</i> and Its Related Immune Infiltration in Liver Hepatocellular Carcinoma |
| title_short | The Prognostic Significance of <i>FKBP1A</i> and Its Related Immune Infiltration in Liver Hepatocellular Carcinoma |
| title_sort | prognostic significance of i fkbp1a i and its related immune infiltration in liver hepatocellular carcinoma |
| topic | <i>FKBP1A</i> hepatocellular carcinoma bioinformatics analysis immune infiltration prognostic biomarker |
| url | https://www.mdpi.com/1422-0067/23/21/12797 |
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