ATRX promotes maintenance of herpes simplex virus heterochromatin during chromatin stress

ATRX promotes maintenance of herpes simplex virus heterochromatin during chromatin stress

The mechanisms by which mammalian cells recognize and epigenetically restrict viral DNA are not well defined. We used herpes simplex virus with bioorthogonally labeled genomes to detect host factors recruited to viral DNA shortly after its nuclear entry and found that the cellular IFI16, PML, and AT...

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Bibliographic Details
Main Authors: Joseph M Cabral, Hyung Suk Oh, David M Knipe
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-11-01
Series:eLife
Subjects:
herpes simplex virus
ATRX
epigenetics
viral restriction
heterochromatin
IFI16
Online Access:https://elifesciences.org/articles/40228

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