Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow
ABSTRACTHepatitis E virus (HEV) infection is primarily manifesting as acute hepatitis, but extra-hepatic replication and injury are frequently reported. During the study period, we discovered two acute myeloid leukaemia (AML) patients infected with HEV genotype 3 and 4, respectively, and HEV RNA and...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2020.1761762 |
| _version_ | 1797265833760653312 |
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| author | Lin Wang Li Yan Jieling Jiang Yuyi Zhang Qiyu He Hui Zhuang Ling Wang |
| author_facet | Lin Wang Li Yan Jieling Jiang Yuyi Zhang Qiyu He Hui Zhuang Ling Wang |
| author_sort | Lin Wang |
| collection | DOAJ |
| description | ABSTRACTHepatitis E virus (HEV) infection is primarily manifesting as acute hepatitis, but extra-hepatic replication and injury are frequently reported. During the study period, we discovered two acute myeloid leukaemia (AML) patients infected with HEV genotype 3 and 4, respectively, and HEV RNA and/or viral proteins were persistently detected in the bone marrow of both patients. The finding suggests that HEV can replicate in human bone marrow as it may serve as a new target site and reservoir of HEV persistence. |
| first_indexed | 2024-03-07T17:24:34Z |
| format | Article |
| id | doaj.art-dd5d01df0d60411a8d566c9135f16a6f |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-04-25T00:51:05Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-dd5d01df0d60411a8d566c9135f16a6f2024-03-11T16:04:25ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512020-01-019199499710.1080/22221751.2020.1761762Presence and persistence of hepatitis E virus RNA and proteins in human bone marrowLin Wang0Li Yan1Jieling Jiang2Yuyi Zhang3Qiyu He4Hui Zhuang5Ling Wang6Department of Microbiology and Infectious Disease Centre, School of Basic Medical Sciences, Peking University Health Science Centre, Beijing, People’s Republic of ChinaDepartment of Severe Hepatology, Shanghai Public Health Clinical Centre, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of ChinaDepartment of Severe Hepatology, Shanghai Public Health Clinical Centre, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Microbiology and Infectious Disease Centre, School of Basic Medical Sciences, Peking University Health Science Centre, Beijing, People’s Republic of ChinaDepartment of Microbiology and Infectious Disease Centre, School of Basic Medical Sciences, Peking University Health Science Centre, Beijing, People’s Republic of ChinaDepartment of Microbiology and Infectious Disease Centre, School of Basic Medical Sciences, Peking University Health Science Centre, Beijing, People’s Republic of ChinaABSTRACTHepatitis E virus (HEV) infection is primarily manifesting as acute hepatitis, but extra-hepatic replication and injury are frequently reported. During the study period, we discovered two acute myeloid leukaemia (AML) patients infected with HEV genotype 3 and 4, respectively, and HEV RNA and/or viral proteins were persistently detected in the bone marrow of both patients. The finding suggests that HEV can replicate in human bone marrow as it may serve as a new target site and reservoir of HEV persistence.https://www.tandfonline.com/doi/10.1080/22221751.2020.1761762Hepatitis E virushepatitis Eextra-hepatic replicationbone marrow |
| spellingShingle | Lin Wang Li Yan Jieling Jiang Yuyi Zhang Qiyu He Hui Zhuang Ling Wang Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow Emerging Microbes and Infections Hepatitis E virus hepatitis E extra-hepatic replication bone marrow |
| title | Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow |
| title_full | Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow |
| title_fullStr | Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow |
| title_full_unstemmed | Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow |
| title_short | Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow |
| title_sort | presence and persistence of hepatitis e virus rna and proteins in human bone marrow |
| topic | Hepatitis E virus hepatitis E extra-hepatic replication bone marrow |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2020.1761762 |
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