Bone metastases from renal cell carcinoma: patient survival after surgical treatment
<p>Abstract</p> <p>Background</p> <p>Surgery is the primary treatment of skeletal metastases from renal cell carcinoma, because radiation and chemotherapy frequently are not effecting the survival. We therefore explored factors potentially affecting the survival of pati...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-07-01
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| Series: | BMC Musculoskeletal Disorders |
| Online Access: | http://www.biomedcentral.com/1471-2474/11/145 |
| _version_ | 1811285961691103232 |
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| author | Baur-Melnyk Andrea Stähler Michael Wirthmann Lilly Szalantzy Melinda Fottner Andreas Jansson Volkmar Dürr Hans |
| author_facet | Baur-Melnyk Andrea Stähler Michael Wirthmann Lilly Szalantzy Melinda Fottner Andreas Jansson Volkmar Dürr Hans |
| author_sort | Baur-Melnyk Andrea |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Surgery is the primary treatment of skeletal metastases from renal cell carcinoma, because radiation and chemotherapy frequently are not effecting the survival. We therefore explored factors potentially affecting the survival of patients after surgical treatment.</p> <p>Methods</p> <p>We retrospectively reviewed 101 patients operatively treated for skeletal metastases of renal cell carcinoma between 1980 and 2005. Overall survival was calculated using the Kaplan-Meier method. The effects of different variables were evaluated using a log-rank test.</p> <p>Results</p> <p>27 patients had a solitary bone metastasis, 20 patients multiple bone metastases and 54 patients had concomitant visceral metastases. The overall survival was 58% at 1 year, 37% at 2 years and 12% at 5 years. Patients with solitary bone metastases had a better survival (p < 0.001) compared to patients with multiple metastases. Age younger than 65 years (p = 0.036), absence of pathologic fractures (p < 0.001) and tumor-free resection margins (p = 0.028) predicted higher survival. Gender, location of metastases, time between diagnosis of renal cell carcinoma and treatment of metastatic disease, incidence of local recurrence, radiation and chemotherapy did not influence survival.</p> <p>Conclusions</p> <p>The data suggest that patients with a solitary metastasis or a limited number of resectable metastases are candidates for wide resections. As radiation and chemotherapy are ineffective in most patients, surgery is a better option to achieve local tumor control and increase the survival.</p> |
| first_indexed | 2024-04-13T02:52:42Z |
| format | Article |
| id | doaj.art-dd5d1612b7f3438daeeb75f57d082f0d |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-04-13T02:52:42Z |
| publishDate | 2010-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-dd5d1612b7f3438daeeb75f57d082f0d2022-12-22T03:05:48ZengBMCBMC Musculoskeletal Disorders1471-24742010-07-0111114510.1186/1471-2474-11-145Bone metastases from renal cell carcinoma: patient survival after surgical treatmentBaur-Melnyk AndreaStähler MichaelWirthmann LillySzalantzy MelindaFottner AndreasJansson VolkmarDürr Hans<p>Abstract</p> <p>Background</p> <p>Surgery is the primary treatment of skeletal metastases from renal cell carcinoma, because radiation and chemotherapy frequently are not effecting the survival. We therefore explored factors potentially affecting the survival of patients after surgical treatment.</p> <p>Methods</p> <p>We retrospectively reviewed 101 patients operatively treated for skeletal metastases of renal cell carcinoma between 1980 and 2005. Overall survival was calculated using the Kaplan-Meier method. The effects of different variables were evaluated using a log-rank test.</p> <p>Results</p> <p>27 patients had a solitary bone metastasis, 20 patients multiple bone metastases and 54 patients had concomitant visceral metastases. The overall survival was 58% at 1 year, 37% at 2 years and 12% at 5 years. Patients with solitary bone metastases had a better survival (p < 0.001) compared to patients with multiple metastases. Age younger than 65 years (p = 0.036), absence of pathologic fractures (p < 0.001) and tumor-free resection margins (p = 0.028) predicted higher survival. Gender, location of metastases, time between diagnosis of renal cell carcinoma and treatment of metastatic disease, incidence of local recurrence, radiation and chemotherapy did not influence survival.</p> <p>Conclusions</p> <p>The data suggest that patients with a solitary metastasis or a limited number of resectable metastases are candidates for wide resections. As radiation and chemotherapy are ineffective in most patients, surgery is a better option to achieve local tumor control and increase the survival.</p>http://www.biomedcentral.com/1471-2474/11/145 |
| spellingShingle | Baur-Melnyk Andrea Stähler Michael Wirthmann Lilly Szalantzy Melinda Fottner Andreas Jansson Volkmar Dürr Hans Bone metastases from renal cell carcinoma: patient survival after surgical treatment BMC Musculoskeletal Disorders |
| title | Bone metastases from renal cell carcinoma: patient survival after surgical treatment |
| title_full | Bone metastases from renal cell carcinoma: patient survival after surgical treatment |
| title_fullStr | Bone metastases from renal cell carcinoma: patient survival after surgical treatment |
| title_full_unstemmed | Bone metastases from renal cell carcinoma: patient survival after surgical treatment |
| title_short | Bone metastases from renal cell carcinoma: patient survival after surgical treatment |
| title_sort | bone metastases from renal cell carcinoma patient survival after surgical treatment |
| url | http://www.biomedcentral.com/1471-2474/11/145 |
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