Impact of Chronic Fetal Hypoxia and Inflammation on Cardiac Pacemaker Cell Development
Chronic fetal hypoxia and infection are examples of adverse conditions during complicated pregnancy, which impact cardiac myogenesis and increase the lifetime risk of heart disease. However, the effects that chronic hypoxic or inflammatory environments exert on cardiac pacemaker cells are poorly und...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-03-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/3/733 |
| _version_ | 1797728649925885952 |
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| author | Martin G. Frasch Dino A. Giussani |
| author_facet | Martin G. Frasch Dino A. Giussani |
| author_sort | Martin G. Frasch |
| collection | DOAJ |
| description | Chronic fetal hypoxia and infection are examples of adverse conditions during complicated pregnancy, which impact cardiac myogenesis and increase the lifetime risk of heart disease. However, the effects that chronic hypoxic or inflammatory environments exert on cardiac pacemaker cells are poorly understood. Here, we review the current evidence and novel avenues of bench-to-bed research in this field of perinatal cardiogenesis as well as its translational significance for early detection of future risk for cardiovascular disease. |
| first_indexed | 2024-03-12T11:17:10Z |
| format | Article |
| id | doaj.art-dd5fa57a878648f887e32707268dc478 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T11:17:10Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-dd5fa57a878648f887e32707268dc4782023-09-02T01:54:00ZengMDPI AGCells2073-44092020-03-019373310.3390/cells9030733cells9030733Impact of Chronic Fetal Hypoxia and Inflammation on Cardiac Pacemaker Cell DevelopmentMartin G. Frasch0Dino A. Giussani1Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195, USADepartment of Physiology, Development & Neuroscience, University of Cambridge, Cambridge CB2 1TN, UKChronic fetal hypoxia and infection are examples of adverse conditions during complicated pregnancy, which impact cardiac myogenesis and increase the lifetime risk of heart disease. However, the effects that chronic hypoxic or inflammatory environments exert on cardiac pacemaker cells are poorly understood. Here, we review the current evidence and novel avenues of bench-to-bed research in this field of perinatal cardiogenesis as well as its translational significance for early detection of future risk for cardiovascular disease.https://www.mdpi.com/2073-4409/9/3/733intrinsic heart rate variabilityihrvfetal programmingcardiac developmentsinus node |
| spellingShingle | Martin G. Frasch Dino A. Giussani Impact of Chronic Fetal Hypoxia and Inflammation on Cardiac Pacemaker Cell Development Cells intrinsic heart rate variability ihrv fetal programming cardiac development sinus node |
| title | Impact of Chronic Fetal Hypoxia and Inflammation on Cardiac Pacemaker Cell Development |
| title_full | Impact of Chronic Fetal Hypoxia and Inflammation on Cardiac Pacemaker Cell Development |
| title_fullStr | Impact of Chronic Fetal Hypoxia and Inflammation on Cardiac Pacemaker Cell Development |
| title_full_unstemmed | Impact of Chronic Fetal Hypoxia and Inflammation on Cardiac Pacemaker Cell Development |
| title_short | Impact of Chronic Fetal Hypoxia and Inflammation on Cardiac Pacemaker Cell Development |
| title_sort | impact of chronic fetal hypoxia and inflammation on cardiac pacemaker cell development |
| topic | intrinsic heart rate variability ihrv fetal programming cardiac development sinus node |
| url | https://www.mdpi.com/2073-4409/9/3/733 |
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