Protective Effects of <i>Dendropanax morbifera</i> against Cisplatin-Induced Nephrotoxicity without Altering Chemotherapeutic Efficacy
Use of the chemotherapeutic agent cisplatin (CDDP) in cancer patients is limited by the occurrence of acute kidney injury (AKI); however, no protective therapy is available. We aimed to investigate the renoprotective effects of <i>Dendropanax morbifera</i> water extract (DM) on CDDP-indu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-07-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/8/8/256 |
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| author | Ji Su Kim Kyeong Seok Kim Ji Yeon Son Hae Ri Kim Jae Hyeon Park Su Hyun Lee Da Eun Lee In Su Kim Kwang Youl Lee Byung Mu Lee Jong Hwan Kwak Hyung Sik Kim |
| author_facet | Ji Su Kim Kyeong Seok Kim Ji Yeon Son Hae Ri Kim Jae Hyeon Park Su Hyun Lee Da Eun Lee In Su Kim Kwang Youl Lee Byung Mu Lee Jong Hwan Kwak Hyung Sik Kim |
| author_sort | Ji Su Kim |
| collection | DOAJ |
| description | Use of the chemotherapeutic agent cisplatin (CDDP) in cancer patients is limited by the occurrence of acute kidney injury (AKI); however, no protective therapy is available. We aimed to investigate the renoprotective effects of <i>Dendropanax morbifera</i> water extract (DM) on CDDP-induced AKI. Male Sprague-Dawley rats (six animals/group) received: Vehicle (control); CDDP (6 mg/kg, intraperitoneally (i.p.); DM (25 mg/kg, oral); or DM + CDDP injection. CDDP treatment significantly increased blood urea nitrogen (BUN), serum creatinine (sCr), and pro-inflammatory cytokines (IL-6 and TNF-α), and severely damaged the kidney architecture. Urinary excretion of protein-based AKI biomarkers also increased in the CDDP-treated group. In contrast, DM ameliorated CDDP-induced AKI biomarkers. It markedly protected against CDDP-induced oxidative stress by increasing the activity of endogenous antioxidants and reducing the levels of pro-inflammatory cytokines (IL-6 and TNF-α). The protective effect of DM in the proximal tubules was evident upon histopathological examination. In a tumor xenograft model, administration of DM enhanced the chemotherapeutic activity of CDDP and exhibited renoprotective effects against CDDP-induced nephrotoxicity without altering chemotherapeutic efficacy. Our data demonstrate that DM may be an adjuvant therapy with CDDP in solid tumor patients to preserve renal function. |
| first_indexed | 2024-03-12T19:13:32Z |
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| id | doaj.art-dd6046c35d9749e8bbe2a7d6a442fabf |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T19:13:32Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-dd6046c35d9749e8bbe2a7d6a442fabf2023-08-02T05:41:29ZengMDPI AGAntioxidants2076-39212019-07-018825610.3390/antiox8080256antiox8080256Protective Effects of <i>Dendropanax morbifera</i> against Cisplatin-Induced Nephrotoxicity without Altering Chemotherapeutic EfficacyJi Su Kim0Kyeong Seok Kim1Ji Yeon Son2Hae Ri Kim3Jae Hyeon Park4Su Hyun Lee5Da Eun Lee6In Su Kim7Kwang Youl Lee8Byung Mu Lee9Jong Hwan Kwak10Hyung Sik Kim11Division of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon 16419, KoreaDivision of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon 16419, KoreaDivision of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon 16419, KoreaDivision of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon 16419, KoreaDivision of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon 16419, KoreaDivision of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon 16419, KoreaDivision of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon 16419, KoreaDivision of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon 16419, KoreaDivision of Molecular Biology, College of Pharmacy & Research Institute of Drug Development, Chonnam National University, Gwangju 61186, KoreaDivision of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon 16419, KoreaDivision of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon 16419, KoreaDivision of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon 16419, KoreaUse of the chemotherapeutic agent cisplatin (CDDP) in cancer patients is limited by the occurrence of acute kidney injury (AKI); however, no protective therapy is available. We aimed to investigate the renoprotective effects of <i>Dendropanax morbifera</i> water extract (DM) on CDDP-induced AKI. Male Sprague-Dawley rats (six animals/group) received: Vehicle (control); CDDP (6 mg/kg, intraperitoneally (i.p.); DM (25 mg/kg, oral); or DM + CDDP injection. CDDP treatment significantly increased blood urea nitrogen (BUN), serum creatinine (sCr), and pro-inflammatory cytokines (IL-6 and TNF-α), and severely damaged the kidney architecture. Urinary excretion of protein-based AKI biomarkers also increased in the CDDP-treated group. In contrast, DM ameliorated CDDP-induced AKI biomarkers. It markedly protected against CDDP-induced oxidative stress by increasing the activity of endogenous antioxidants and reducing the levels of pro-inflammatory cytokines (IL-6 and TNF-α). The protective effect of DM in the proximal tubules was evident upon histopathological examination. In a tumor xenograft model, administration of DM enhanced the chemotherapeutic activity of CDDP and exhibited renoprotective effects against CDDP-induced nephrotoxicity without altering chemotherapeutic efficacy. Our data demonstrate that DM may be an adjuvant therapy with CDDP in solid tumor patients to preserve renal function.https://www.mdpi.com/2076-3921/8/8/256cisplatin<i>Dendropanax morbifera</i>renoprotective effectantioxidantschemotherapyxenograft model |
| spellingShingle | Ji Su Kim Kyeong Seok Kim Ji Yeon Son Hae Ri Kim Jae Hyeon Park Su Hyun Lee Da Eun Lee In Su Kim Kwang Youl Lee Byung Mu Lee Jong Hwan Kwak Hyung Sik Kim Protective Effects of <i>Dendropanax morbifera</i> against Cisplatin-Induced Nephrotoxicity without Altering Chemotherapeutic Efficacy Antioxidants cisplatin <i>Dendropanax morbifera</i> renoprotective effect antioxidants chemotherapy xenograft model |
| title | Protective Effects of <i>Dendropanax morbifera</i> against Cisplatin-Induced Nephrotoxicity without Altering Chemotherapeutic Efficacy |
| title_full | Protective Effects of <i>Dendropanax morbifera</i> against Cisplatin-Induced Nephrotoxicity without Altering Chemotherapeutic Efficacy |
| title_fullStr | Protective Effects of <i>Dendropanax morbifera</i> against Cisplatin-Induced Nephrotoxicity without Altering Chemotherapeutic Efficacy |
| title_full_unstemmed | Protective Effects of <i>Dendropanax morbifera</i> against Cisplatin-Induced Nephrotoxicity without Altering Chemotherapeutic Efficacy |
| title_short | Protective Effects of <i>Dendropanax morbifera</i> against Cisplatin-Induced Nephrotoxicity without Altering Chemotherapeutic Efficacy |
| title_sort | protective effects of i dendropanax morbifera i against cisplatin induced nephrotoxicity without altering chemotherapeutic efficacy |
| topic | cisplatin <i>Dendropanax morbifera</i> renoprotective effect antioxidants chemotherapy xenograft model |
| url | https://www.mdpi.com/2076-3921/8/8/256 |
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