Arteriovenous Malformations—Current Understanding of the Pathogenesis with Implications for Treatment
Arteriovenous malformations are a vascular anomaly typically present at birth, characterized by an abnormal connection between an artery and a vein (bypassing the capillaries). These high flow lesions can vary in size and location. Therapeutic approaches are limited, and AVMs can cause significant m...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/16/9037 |
| _version_ | 1797523533612449792 |
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| author | Katharina Schimmel Md Khadem Ali Serena Y. Tan Joyce Teng Huy M. Do Gary K. Steinberg David A. Stevenson Edda Spiekerkoetter |
| author_facet | Katharina Schimmel Md Khadem Ali Serena Y. Tan Joyce Teng Huy M. Do Gary K. Steinberg David A. Stevenson Edda Spiekerkoetter |
| author_sort | Katharina Schimmel |
| collection | DOAJ |
| description | Arteriovenous malformations are a vascular anomaly typically present at birth, characterized by an abnormal connection between an artery and a vein (bypassing the capillaries). These high flow lesions can vary in size and location. Therapeutic approaches are limited, and AVMs can cause significant morbidity and mortality. Here, we describe our current understanding of the pathogenesis of arteriovenous malformations based on preclinical and clinical findings. We discuss past and present accomplishments and challenges in the field and identify research gaps that need to be filled for the successful development of therapeutic strategies in the future. |
| first_indexed | 2024-03-10T08:44:20Z |
| format | Article |
| id | doaj.art-dd606c830b1b45a49c43cd4d52988b7c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T08:44:20Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-dd606c830b1b45a49c43cd4d52988b7c2023-11-22T08:04:28ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-08-012216903710.3390/ijms22169037Arteriovenous Malformations—Current Understanding of the Pathogenesis with Implications for TreatmentKatharina Schimmel0Md Khadem Ali1Serena Y. Tan2Joyce Teng3Huy M. Do4Gary K. Steinberg5David A. Stevenson6Edda Spiekerkoetter7Division Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USADivision Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USADepartment of Pathology, Stanford University, Stanford, CA 94305, USADepartment of Dermatology, Lucile Packard Children’s Hospital, Stanford University, Stanford, CA 94305, USADepartment of Radiology (Neuroimaging and Neurointervention), Stanford University, Stanford, CA 94305, USADepartment of Neurosurgery and Stanford Stroke Center, Stanford University, Stanford, CA 94305, USADepartment of Pediatrics, Division of Medical Genetics, Stanford University, Stanford, CA 94305, USADivision Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USAArteriovenous malformations are a vascular anomaly typically present at birth, characterized by an abnormal connection between an artery and a vein (bypassing the capillaries). These high flow lesions can vary in size and location. Therapeutic approaches are limited, and AVMs can cause significant morbidity and mortality. Here, we describe our current understanding of the pathogenesis of arteriovenous malformations based on preclinical and clinical findings. We discuss past and present accomplishments and challenges in the field and identify research gaps that need to be filled for the successful development of therapeutic strategies in the future.https://www.mdpi.com/1422-0067/22/16/9037vascular anomaliesarteriovenous malformationshereditary hemorrhagictelangiectasiaendothelial cellpathogenesis |
| spellingShingle | Katharina Schimmel Md Khadem Ali Serena Y. Tan Joyce Teng Huy M. Do Gary K. Steinberg David A. Stevenson Edda Spiekerkoetter Arteriovenous Malformations—Current Understanding of the Pathogenesis with Implications for Treatment International Journal of Molecular Sciences vascular anomalies arteriovenous malformations hereditary hemorrhagic telangiectasia endothelial cell pathogenesis |
| title | Arteriovenous Malformations—Current Understanding of the Pathogenesis with Implications for Treatment |
| title_full | Arteriovenous Malformations—Current Understanding of the Pathogenesis with Implications for Treatment |
| title_fullStr | Arteriovenous Malformations—Current Understanding of the Pathogenesis with Implications for Treatment |
| title_full_unstemmed | Arteriovenous Malformations—Current Understanding of the Pathogenesis with Implications for Treatment |
| title_short | Arteriovenous Malformations—Current Understanding of the Pathogenesis with Implications for Treatment |
| title_sort | arteriovenous malformations current understanding of the pathogenesis with implications for treatment |
| topic | vascular anomalies arteriovenous malformations hereditary hemorrhagic telangiectasia endothelial cell pathogenesis |
| url | https://www.mdpi.com/1422-0067/22/16/9037 |
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