The impact of S2 mutations on Omicron SARS-CoV-2 cell surface expression and fusogenicity

The impact of S2 mutations on Omicron SARS-CoV-2 cell surface expression and fusogenicity

ABSTRACTSARS-CoV-2 Omicron subvariants are still emerging and spreading worldwide. These variants contain a high number of polymorphisms in the spike (S) glycoprotein that could potentially impact their pathogenicity and transmission. We have previously shown that the S:655Y and P681H mutations enha...

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Bibliographic Details
Main Authors: Alba Escalera, Manon Laporte, Sam Turner, Umut Karakus, Ana S. Gonzalez-Reiche, Adriana van de Guchte, Keith Farrugia, Zain Khalil, Harm van Bakel, Derek Smith, Adolfo García-Sastre, Teresa Aydillo
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Emerging Microbes and Infections
Subjects:
SARS-CoV-2
Omicron
spike
cell–cell fusion
spike cell surface expression
“first-generation” Omicron sublineages
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2023.2297553

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