MicroRNA-221: A Fine Tuner and Potential Biomarker of Chronic Liver Injury
The last decade has witnessed significant advancements in our understanding of how small noncoding RNAs, such as microRNAs (miRNAs), regulate disease progression. One such miRNA, miR-221, has been shown to play a key role in the progression of liver fibrosis, a common feature of most liver diseases....
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/8/1767 |
| _version_ | 1797561544302657536 |
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| author | Jovana Markovic Amar Deep Sharma Asha Balakrishnan |
| author_facet | Jovana Markovic Amar Deep Sharma Asha Balakrishnan |
| author_sort | Jovana Markovic |
| collection | DOAJ |
| description | The last decade has witnessed significant advancements in our understanding of how small noncoding RNAs, such as microRNAs (miRNAs), regulate disease progression. One such miRNA, miR-221, has been shown to play a key role in the progression of liver fibrosis, a common feature of most liver diseases. Many reports have demonstrated the upregulation of miR-221 in liver fibrosis caused by multiple etiologies such as viral infections and nonalcoholic steatohepatitis. Inhibition of miR-221 via different strategies has shown promising results in terms of the suppression of fibrogenic gene signatures in vitro, as well as in vivo, in independent mouse models of liver fibrosis. In addition, miR-221 has also been suggested as a noninvasive serum biomarker for liver fibrosis and cirrhosis. In this review, we discuss the biology of miR-221, its significance and use as a biomarker during progression of liver fibrosis, and finally, potential and robust approaches that can be utilized to suppress liver fibrosis via inhibition of miR-221. |
| first_indexed | 2024-03-10T18:16:24Z |
| format | Article |
| id | doaj.art-dd6533cc6c964c01938bfbe34b2fabab |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T18:16:24Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-dd6533cc6c964c01938bfbe34b2fabab2023-11-20T07:43:01ZengMDPI AGCells2073-44092020-07-0198176710.3390/cells9081767MicroRNA-221: A Fine Tuner and Potential Biomarker of Chronic Liver InjuryJovana Markovic0Amar Deep Sharma1Asha Balakrishnan2Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, 30625 Hannover, GermanyDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, 30625 Hannover, GermanyDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, 30625 Hannover, GermanyThe last decade has witnessed significant advancements in our understanding of how small noncoding RNAs, such as microRNAs (miRNAs), regulate disease progression. One such miRNA, miR-221, has been shown to play a key role in the progression of liver fibrosis, a common feature of most liver diseases. Many reports have demonstrated the upregulation of miR-221 in liver fibrosis caused by multiple etiologies such as viral infections and nonalcoholic steatohepatitis. Inhibition of miR-221 via different strategies has shown promising results in terms of the suppression of fibrogenic gene signatures in vitro, as well as in vivo, in independent mouse models of liver fibrosis. In addition, miR-221 has also been suggested as a noninvasive serum biomarker for liver fibrosis and cirrhosis. In this review, we discuss the biology of miR-221, its significance and use as a biomarker during progression of liver fibrosis, and finally, potential and robust approaches that can be utilized to suppress liver fibrosis via inhibition of miR-221.https://www.mdpi.com/2073-4409/9/8/1767miR-221liver fibrosisHCCNASHnoninvasive biomarker |
| spellingShingle | Jovana Markovic Amar Deep Sharma Asha Balakrishnan MicroRNA-221: A Fine Tuner and Potential Biomarker of Chronic Liver Injury Cells miR-221 liver fibrosis HCC NASH noninvasive biomarker |
| title | MicroRNA-221: A Fine Tuner and Potential Biomarker of Chronic Liver Injury |
| title_full | MicroRNA-221: A Fine Tuner and Potential Biomarker of Chronic Liver Injury |
| title_fullStr | MicroRNA-221: A Fine Tuner and Potential Biomarker of Chronic Liver Injury |
| title_full_unstemmed | MicroRNA-221: A Fine Tuner and Potential Biomarker of Chronic Liver Injury |
| title_short | MicroRNA-221: A Fine Tuner and Potential Biomarker of Chronic Liver Injury |
| title_sort | microrna 221 a fine tuner and potential biomarker of chronic liver injury |
| topic | miR-221 liver fibrosis HCC NASH noninvasive biomarker |
| url | https://www.mdpi.com/2073-4409/9/8/1767 |
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