Association of Circular RNAs levels in blood and Essential Hypertension with Carotid Plaque
Background As one of the essential hypertension (EH)-mediated target organ damage, carotid plaque is a crucial subclinical precursor for cardiovascular events. Therefore, it is vital to identify the risk factors and pathogenesis for EH with carotid plaque. Methods Based on our previous microarray an...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641963.2023.2180020 |
| _version_ | 1797681057152106496 |
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| author | Haiyan Qian Zebo Zhang Zhenbo Tao Yanqing Xie Yueqi Yin Wenming He Lina Zhang |
| author_facet | Haiyan Qian Zebo Zhang Zhenbo Tao Yanqing Xie Yueqi Yin Wenming He Lina Zhang |
| author_sort | Haiyan Qian |
| collection | DOAJ |
| description | Background As one of the essential hypertension (EH)-mediated target organ damage, carotid plaque is a crucial subclinical precursor for cardiovascular events. Therefore, it is vital to identify the risk factors and pathogenesis for EH with carotid plaque. Methods Based on our previous microarray analysis, we selected four circRNAs as the candidate circRNAs and detected their expression levels in blood of 192 subjects (64 healthy controls, 64 EH patients, and 64 EH patients with carotid plaque) by qRT-PCR analysis. The regulatory mechanism of circRNAs involved in carotid plaque was predicted by bioinformatics analysis. Results The level of hsa_circ_0124782 increased significantly and the levels of hsa_circ_0131618 and hsa_circ_0127342 decreased significantly in the EH group and EH with carotid plaque group compared with the control group (P < .05). Functional enrichment analysis showed that three circRNAs might be implicated in pathogenesis for carotid plaque. Conclusion Our study revealed the relationship between three circRNAs and carotid plaque, suggesting that they may serve as potential biomarkers for EH with carotid plaque. |
| first_indexed | 2024-03-11T23:39:22Z |
| format | Article |
| id | doaj.art-dd65a50a751a4c7b9837b6a62862ad82 |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:39:22Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-dd65a50a751a4c7b9837b6a62862ad822023-09-19T16:04:08ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062023-12-0145110.1080/10641963.2023.21800202180020Association of Circular RNAs levels in blood and Essential Hypertension with Carotid PlaqueHaiyan Qian0Zebo Zhang1Zhenbo Tao2Yanqing Xie3Yueqi Yin4Wenming He5Lina Zhang6School of Medicine, Ningbo UniversitySchool of Medicine, Ningbo UniversitySchool of Medicine, Ningbo UniversityInstitute of Geriatrics, the Affiliated Hospital of Medical School, Ningbo UniversitySchool of Medicine, Ningbo UniversityInstitute of Geriatrics, the Affiliated Hospital of Medical School, Ningbo UniversitySchool of Medicine, Ningbo UniversityBackground As one of the essential hypertension (EH)-mediated target organ damage, carotid plaque is a crucial subclinical precursor for cardiovascular events. Therefore, it is vital to identify the risk factors and pathogenesis for EH with carotid plaque. Methods Based on our previous microarray analysis, we selected four circRNAs as the candidate circRNAs and detected their expression levels in blood of 192 subjects (64 healthy controls, 64 EH patients, and 64 EH patients with carotid plaque) by qRT-PCR analysis. The regulatory mechanism of circRNAs involved in carotid plaque was predicted by bioinformatics analysis. Results The level of hsa_circ_0124782 increased significantly and the levels of hsa_circ_0131618 and hsa_circ_0127342 decreased significantly in the EH group and EH with carotid plaque group compared with the control group (P < .05). Functional enrichment analysis showed that three circRNAs might be implicated in pathogenesis for carotid plaque. Conclusion Our study revealed the relationship between three circRNAs and carotid plaque, suggesting that they may serve as potential biomarkers for EH with carotid plaque.http://dx.doi.org/10.1080/10641963.2023.2180020essential hypertensioncarotid plaquecircular rnadiagnostic valueregulatory network |
| spellingShingle | Haiyan Qian Zebo Zhang Zhenbo Tao Yanqing Xie Yueqi Yin Wenming He Lina Zhang Association of Circular RNAs levels in blood and Essential Hypertension with Carotid Plaque Clinical and Experimental Hypertension essential hypertension carotid plaque circular rna diagnostic value regulatory network |
| title | Association of Circular RNAs levels in blood and Essential Hypertension with Carotid Plaque |
| title_full | Association of Circular RNAs levels in blood and Essential Hypertension with Carotid Plaque |
| title_fullStr | Association of Circular RNAs levels in blood and Essential Hypertension with Carotid Plaque |
| title_full_unstemmed | Association of Circular RNAs levels in blood and Essential Hypertension with Carotid Plaque |
| title_short | Association of Circular RNAs levels in blood and Essential Hypertension with Carotid Plaque |
| title_sort | association of circular rnas levels in blood and essential hypertension with carotid plaque |
| topic | essential hypertension carotid plaque circular rna diagnostic value regulatory network |
| url | http://dx.doi.org/10.1080/10641963.2023.2180020 |
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