Genotoxic effects among petrol station workers.
Background: Benzene has been internationally recognized as a potent toxin, particularly for its effects on the blood forming system of the bone marrow and its association to a large number of haematological disorders. Aims: This study aimed to assess the cytogenetic damages related to occupational e...
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| Format: | Article |
| Language: | English |
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College of Medicine University of Baghdad
2007-10-01
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| Series: | مجلة كلية الطب |
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| Online Access: | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1359 |
| _version_ | 1827393374418632704 |
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| author | Abdul-Hussain M. Al-Faisal |
| author_facet | Abdul-Hussain M. Al-Faisal |
| author_sort | Abdul-Hussain M. Al-Faisal |
| collection | DOAJ |
| description | Background: Benzene has been internationally recognized as a potent toxin, particularly for its effects on the blood forming system of the bone marrow and its association to a large number of haematological disorders.
Aims: This study aimed to assess the cytogenetic damages related to occupational exposure to benzene by calculating the mitotic index ( MI) , nuclear division cytotoxicity index ( NDCI), binucleated cells ratio and chromosomal aberrations.
Obgectives: Peripheral blood samples were collected from 30 benzene exposed workers and 10 from unexposed- controls- persons. 20 out of the exposed workers were occupationally exposed to benzene from 2 to more than 4 years. The rest of workers were exposed to benzene from one month to one year. Results: The mean MI in the benzene exposed workers ( 5.72 ± 0.62 ) M’as found significantly higher than in controls ( 4.03 ±0.37 ). The highest MI mean M’as calculated in the exposure group 4 to above vears.The NDCI of the exposure workers ( 3.38 ±0.54 )was also significantly higher than in control ( 2.04 ± 0.76 ).Lower NDCI mean was calculated in the 4 to above years exposure.
Conclusions: Chromosomal aberrations were observed in the exposed group. Polyploidy , anuploidy ( 5 monosomy and 9 trisomy ) and structural aberration ( del 8q ) were detected in the exposed groups 0-3 years.
MN frequencies were significantly increased in relation with length of employment. According to the KIN results and the chromosomal aberrations detected in the exposed groups, it could be possible that a correlation found between the elevated values of the KIN and the detected chromosomal aberrations. Keywords: Benzene, Chromosomal aberrations, AIN |
| first_indexed | 2024-03-08T17:48:37Z |
| format | Article |
| id | doaj.art-dd67e2164af441829bd5597fdcfb2014 |
| institution | Directory Open Access Journal |
| issn | 0041-9419 2410-8057 |
| language | English |
| last_indexed | 2024-03-08T17:48:37Z |
| publishDate | 2007-10-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj.art-dd67e2164af441829bd5597fdcfb20142024-01-02T09:55:58ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572007-10-01493Genotoxic effects among petrol station workers.Abdul-Hussain M. Al-Faisal0Iraqi Center for Cancer and Medical Genetics Researches.Background: Benzene has been internationally recognized as a potent toxin, particularly for its effects on the blood forming system of the bone marrow and its association to a large number of haematological disorders. Aims: This study aimed to assess the cytogenetic damages related to occupational exposure to benzene by calculating the mitotic index ( MI) , nuclear division cytotoxicity index ( NDCI), binucleated cells ratio and chromosomal aberrations. Obgectives: Peripheral blood samples were collected from 30 benzene exposed workers and 10 from unexposed- controls- persons. 20 out of the exposed workers were occupationally exposed to benzene from 2 to more than 4 years. The rest of workers were exposed to benzene from one month to one year. Results: The mean MI in the benzene exposed workers ( 5.72 ± 0.62 ) M’as found significantly higher than in controls ( 4.03 ±0.37 ). The highest MI mean M’as calculated in the exposure group 4 to above vears.The NDCI of the exposure workers ( 3.38 ±0.54 )was also significantly higher than in control ( 2.04 ± 0.76 ).Lower NDCI mean was calculated in the 4 to above years exposure. Conclusions: Chromosomal aberrations were observed in the exposed group. Polyploidy , anuploidy ( 5 monosomy and 9 trisomy ) and structural aberration ( del 8q ) were detected in the exposed groups 0-3 years. MN frequencies were significantly increased in relation with length of employment. According to the KIN results and the chromosomal aberrations detected in the exposed groups, it could be possible that a correlation found between the elevated values of the KIN and the detected chromosomal aberrations. Keywords: Benzene, Chromosomal aberrations, AINhttp://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1359Benzene, Chromosomal aberrations, AIN |
| spellingShingle | Abdul-Hussain M. Al-Faisal Genotoxic effects among petrol station workers. مجلة كلية الطب Benzene, Chromosomal aberrations, AIN |
| title | Genotoxic effects among petrol station workers. |
| title_full | Genotoxic effects among petrol station workers. |
| title_fullStr | Genotoxic effects among petrol station workers. |
| title_full_unstemmed | Genotoxic effects among petrol station workers. |
| title_short | Genotoxic effects among petrol station workers. |
| title_sort | genotoxic effects among petrol station workers |
| topic | Benzene, Chromosomal aberrations, AIN |
| url | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1359 |
| work_keys_str_mv | AT abdulhussainmalfaisal genotoxiceffectsamongpetrolstationworkers |