Mapping of positive selection sites in the HIV-1 genome in the context of RNA and protein structural constraints

Mapping of positive selection sites in the HIV-1 genome in the context of RNA and protein structural constraints

<p>Abstract</p> <p>Background</p> <p>The HIV-1 genome is subject to pressures that target the virus resulting in escape and adaptation. On the other hand, there is a requirement for sequence conservation because of functional and structural constraints. Mapping the site...

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Bibliographic Details
Main Authors: Snoeck Joke, Fellay Jacques, Bartha István, Douek Daniel C, Telenti Amalio
Format: Article
Language:English
Published: BMC 2011-11-01
Series:Retrovirology
Subjects:
HIV
evolution
positive selection
RNA structure
Online Access:http://www.retrovirology.com/content/8/1/87

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