Aspirin use and lung cancer risk: a possible relationship? Evidence from an updated meta-analysis.
Growing evidence has emerged and controversial results reported on possible relationship between aspirin use and lung cancer risk. We, therefore, conducted this updated and comprehensive meta-analysis to evaluate this issue, with focus on dose-risk and duration-risk relationships.We searched electro...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4388842?pdf=render |
| _version_ | 1818510196737048576 |
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| author | Hai-yan Jiang Tian-bao Huang Lei Xu Jing Yu Yan Wu Jiang Geng Xu-dong Yao |
| author_facet | Hai-yan Jiang Tian-bao Huang Lei Xu Jing Yu Yan Wu Jiang Geng Xu-dong Yao |
| author_sort | Hai-yan Jiang |
| collection | DOAJ |
| description | Growing evidence has emerged and controversial results reported on possible relationship between aspirin use and lung cancer risk. We, therefore, conducted this updated and comprehensive meta-analysis to evaluate this issue, with focus on dose-risk and duration-risk relationships.We searched electronic databases including PUBMED, EMBASE and Cochrane library to identify eligible studies. Relative risk (RR) and its 95% confidence interval (CI) were used for cohort studies, while odds ratio (OR) were employed for case-control studies. The random effects and fixed effects models were used for analyses.18 studies were identified including 19835 lung cancer cases, which were eligible for inclusion in the present meta-analysis. Pooled data from case-control studies showed a significant inverse association between regular aspirin use and lung cancer risk. But for cohort studies, insignificant association was detected with little evidence of heterogeneity (RR: 1.05, 95%CI: 0.95 - 1.16; I2: 10.3%, p value: 0.351). In case-control studies, standard aspirin use (>325mg) was related to lower lung cancer incidence, compared with low-dose aspirin use (75-100mg). A similar trend was observed in cohort studies. Besides, when analysis was restricted to long time regular aspirin use (>5 years), insignificant results were reported in both cohort and case-control studies. Finally, regular aspirin use might result in higher reduction of non-small cell lung cancer incidence among men.Our findings do not support the protective effect of regular aspirin use on lung cancer risk. Long time aspirin use, sex, dose and type of lung cancer might alter the effect of aspirin use on lung cancer risk. More well-designed studies are needed to further clarify these associations. |
| first_indexed | 2024-12-10T22:56:01Z |
| format | Article |
| id | doaj.art-dd68041ee3fb469d98e918aa690333b9 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T22:56:01Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-dd68041ee3fb469d98e918aa690333b92022-12-22T01:30:17ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01104e012296210.1371/journal.pone.0122962Aspirin use and lung cancer risk: a possible relationship? Evidence from an updated meta-analysis.Hai-yan JiangTian-bao HuangLei XuJing YuYan WuJiang GengXu-dong YaoGrowing evidence has emerged and controversial results reported on possible relationship between aspirin use and lung cancer risk. We, therefore, conducted this updated and comprehensive meta-analysis to evaluate this issue, with focus on dose-risk and duration-risk relationships.We searched electronic databases including PUBMED, EMBASE and Cochrane library to identify eligible studies. Relative risk (RR) and its 95% confidence interval (CI) were used for cohort studies, while odds ratio (OR) were employed for case-control studies. The random effects and fixed effects models were used for analyses.18 studies were identified including 19835 lung cancer cases, which were eligible for inclusion in the present meta-analysis. Pooled data from case-control studies showed a significant inverse association between regular aspirin use and lung cancer risk. But for cohort studies, insignificant association was detected with little evidence of heterogeneity (RR: 1.05, 95%CI: 0.95 - 1.16; I2: 10.3%, p value: 0.351). In case-control studies, standard aspirin use (>325mg) was related to lower lung cancer incidence, compared with low-dose aspirin use (75-100mg). A similar trend was observed in cohort studies. Besides, when analysis was restricted to long time regular aspirin use (>5 years), insignificant results were reported in both cohort and case-control studies. Finally, regular aspirin use might result in higher reduction of non-small cell lung cancer incidence among men.Our findings do not support the protective effect of regular aspirin use on lung cancer risk. Long time aspirin use, sex, dose and type of lung cancer might alter the effect of aspirin use on lung cancer risk. More well-designed studies are needed to further clarify these associations.http://europepmc.org/articles/PMC4388842?pdf=render |
| spellingShingle | Hai-yan Jiang Tian-bao Huang Lei Xu Jing Yu Yan Wu Jiang Geng Xu-dong Yao Aspirin use and lung cancer risk: a possible relationship? Evidence from an updated meta-analysis. PLoS ONE |
| title | Aspirin use and lung cancer risk: a possible relationship? Evidence from an updated meta-analysis. |
| title_full | Aspirin use and lung cancer risk: a possible relationship? Evidence from an updated meta-analysis. |
| title_fullStr | Aspirin use and lung cancer risk: a possible relationship? Evidence from an updated meta-analysis. |
| title_full_unstemmed | Aspirin use and lung cancer risk: a possible relationship? Evidence from an updated meta-analysis. |
| title_short | Aspirin use and lung cancer risk: a possible relationship? Evidence from an updated meta-analysis. |
| title_sort | aspirin use and lung cancer risk a possible relationship evidence from an updated meta analysis |
| url | http://europepmc.org/articles/PMC4388842?pdf=render |
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