Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis[S]

Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis[S]

The accumulation of lipids is a histologic and biochemical hallmark of obesity-associated nonalcoholic fatty liver disease (NAFLD). A subset of NALFD patients develops progressive liver disease, termed nonalcoholic steatohepatitis, which is characterized by hepatocellular apoptosis and innate immune...

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Bibliographic Details
Main Authors: Petra Hirsova, Samar H. Ibrabim, Gregory J. Gores, Harmeet Malhi
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Journal of Lipid Research
Subjects:
nonalcoholic fatty liver disease
steatohepatitis
lipotoxicity
apoptosis
cell death
cell signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520353864

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http://www.sciencedirect.com/science/article/pii/S0022227520353864

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