Inflammatory perspectives of polycystic ovary syndrome: role of specific mediators and markers
Abstract Polycystic ovary syndrome (PCOS) is indeed one of the most common gynecological endocrine disorders, affecting a significant number of females in their reproductive age. While the exact cause of PCOS is not fully understood, several factors are believed to contribute to its onset. The relat...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-12-01
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| Series: | Middle East Fertility Society Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43043-023-00158-2 |
| _version_ | 1797388570642612224 |
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| author | Rajen Dey Koushik Bhattacharya Asim Kumar Basak Nimisha Paul Raktima Bandyopadhyay Gargi Ray Chaudhuri Mahuya Patra Purkait Aniruddha Bhattacharjee Chaitali Bose Nandini Shukla Rama Bhaduri Soumya Sinha Roy Alak Kumar Syamal |
| author_facet | Rajen Dey Koushik Bhattacharya Asim Kumar Basak Nimisha Paul Raktima Bandyopadhyay Gargi Ray Chaudhuri Mahuya Patra Purkait Aniruddha Bhattacharjee Chaitali Bose Nandini Shukla Rama Bhaduri Soumya Sinha Roy Alak Kumar Syamal |
| author_sort | Rajen Dey |
| collection | DOAJ |
| description | Abstract Polycystic ovary syndrome (PCOS) is indeed one of the most common gynecological endocrine disorders, affecting a significant number of females in their reproductive age. While the exact cause of PCOS is not fully understood, several factors are believed to contribute to its onset. The relationship between polycystic ovary syndrome (PCOS) and low-grade chronic inflammation is complex and not fully understood. While there is evidence to suggest an association between PCOS and inflammation, the exact cause and causal nature of this relationship are still under investigation. Several inflammatory markers, including IL-6 (interleukin-6), TNF-α (tumor necrosis factor-alpha), IL-17 (interleukin-17), CRP (C-reactive protein), NLR (neutrophil-to-lymphocyte ratio), and PLR (platelet-to-lymphocyte ratio), have been studied about PCOS. These markers are substances produced by the immune system in response to inflammation. Increased levels of IL-17, IL-1, and IL-8 were correlated with PCO. CRP to albumin ratio can be employed as a precise bio-marker for PCOS. The neutrophil-to-lymphocyte ratio (NLR) indicates poor cardiovascular health and metabolic syndrome (MS) and can be considered a negative regulator for FSH which indirectly stimulates testosterone production. Platelet/lymphocyte ratio (PLR) and mean platelet volume (MPV) are also recently found to be associated with PCOS. The literature explaining the underlying mechanisms with specific inflammatory markers and how inflammation relates to PCOS will be highlighted in this review article. It will also discuss the roles of inflammation and the association of different inflammatory markers in the pathogenesis of PCOS, which may usher in a new era in the treatment approach for PCOS. |
| first_indexed | 2024-03-08T22:41:49Z |
| format | Article |
| id | doaj.art-dd6bde33fc5b4ba5a3a5e26c4c1fdb77 |
| institution | Directory Open Access Journal |
| issn | 2090-3251 |
| language | English |
| last_indexed | 2024-03-08T22:41:49Z |
| publishDate | 2023-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Middle East Fertility Society Journal |
| spelling | doaj.art-dd6bde33fc5b4ba5a3a5e26c4c1fdb772023-12-17T12:07:31ZengSpringerOpenMiddle East Fertility Society Journal2090-32512023-12-0128111210.1186/s43043-023-00158-2Inflammatory perspectives of polycystic ovary syndrome: role of specific mediators and markersRajen Dey0Koushik Bhattacharya1Asim Kumar Basak2Nimisha Paul3Raktima Bandyopadhyay4Gargi Ray Chaudhuri5Mahuya Patra Purkait6Aniruddha Bhattacharjee7Chaitali Bose8Nandini Shukla9Rama Bhaduri10Soumya Sinha Roy11Alak Kumar Syamal12Department of Medical Laboratory Technology, Swami Vivekananda UniversitySchool of Paramedics and Allied Health Sciences, Centurion University of Technology and ManagementSchool of Allied Health Sciences, Brainware UniversityDepartment of Physiology and Biochemistry, Hitkarini Dental College and HospitalDepartment of Nutrition, AKPC Mahavidyalaya [Affiliated to the University of Burdwan]Department of Physiotherapy, Nopany Institute of Health Care StudiesDepartment of Zoology, Sonarpur Mahavidyalaya [Affiliated to the University of Calcutta]Department of Physiology, International Medical School, Management and Science UniversityPost-Graduate Department of Physiology, Hooghly Mohsin CollegeDepartment of Anatomy, Pt.J.N.M. Medical CollegePost-Graduate Department of Physiology, Hooghly Mohsin CollegePost-Graduate Department of Physiology, Hooghly Mohsin CollegePost-Graduate Department of Physiology, Hooghly Mohsin CollegeAbstract Polycystic ovary syndrome (PCOS) is indeed one of the most common gynecological endocrine disorders, affecting a significant number of females in their reproductive age. While the exact cause of PCOS is not fully understood, several factors are believed to contribute to its onset. The relationship between polycystic ovary syndrome (PCOS) and low-grade chronic inflammation is complex and not fully understood. While there is evidence to suggest an association between PCOS and inflammation, the exact cause and causal nature of this relationship are still under investigation. Several inflammatory markers, including IL-6 (interleukin-6), TNF-α (tumor necrosis factor-alpha), IL-17 (interleukin-17), CRP (C-reactive protein), NLR (neutrophil-to-lymphocyte ratio), and PLR (platelet-to-lymphocyte ratio), have been studied about PCOS. These markers are substances produced by the immune system in response to inflammation. Increased levels of IL-17, IL-1, and IL-8 were correlated with PCO. CRP to albumin ratio can be employed as a precise bio-marker for PCOS. The neutrophil-to-lymphocyte ratio (NLR) indicates poor cardiovascular health and metabolic syndrome (MS) and can be considered a negative regulator for FSH which indirectly stimulates testosterone production. Platelet/lymphocyte ratio (PLR) and mean platelet volume (MPV) are also recently found to be associated with PCOS. The literature explaining the underlying mechanisms with specific inflammatory markers and how inflammation relates to PCOS will be highlighted in this review article. It will also discuss the roles of inflammation and the association of different inflammatory markers in the pathogenesis of PCOS, which may usher in a new era in the treatment approach for PCOS.https://doi.org/10.1186/s43043-023-00158-2PCOSInflammationMetabolic syndromeHyperandrogenismInflammatory markers |
| spellingShingle | Rajen Dey Koushik Bhattacharya Asim Kumar Basak Nimisha Paul Raktima Bandyopadhyay Gargi Ray Chaudhuri Mahuya Patra Purkait Aniruddha Bhattacharjee Chaitali Bose Nandini Shukla Rama Bhaduri Soumya Sinha Roy Alak Kumar Syamal Inflammatory perspectives of polycystic ovary syndrome: role of specific mediators and markers Middle East Fertility Society Journal PCOS Inflammation Metabolic syndrome Hyperandrogenism Inflammatory markers |
| title | Inflammatory perspectives of polycystic ovary syndrome: role of specific mediators and markers |
| title_full | Inflammatory perspectives of polycystic ovary syndrome: role of specific mediators and markers |
| title_fullStr | Inflammatory perspectives of polycystic ovary syndrome: role of specific mediators and markers |
| title_full_unstemmed | Inflammatory perspectives of polycystic ovary syndrome: role of specific mediators and markers |
| title_short | Inflammatory perspectives of polycystic ovary syndrome: role of specific mediators and markers |
| title_sort | inflammatory perspectives of polycystic ovary syndrome role of specific mediators and markers |
| topic | PCOS Inflammation Metabolic syndrome Hyperandrogenism Inflammatory markers |
| url | https://doi.org/10.1186/s43043-023-00158-2 |
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