Genomic and functional studies of Drosophila sex hierarchy regulated gene expression in adult head and nervous system tissues.
The Drosophila sex determination hierarchy controls all aspects of somatic sexual differentiation, including sex-specific differences in adult morphology and behavior. To gain insight into the molecular-genetic specification of reproductive behaviors and physiology, we identified genes expressed in...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2007-11-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC2082469?pdf=render |
| _version_ | 1811262691420930048 |
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| author | Thomas D Goldman Michelle N Arbeitman |
| author_facet | Thomas D Goldman Michelle N Arbeitman |
| author_sort | Thomas D Goldman |
| collection | DOAJ |
| description | The Drosophila sex determination hierarchy controls all aspects of somatic sexual differentiation, including sex-specific differences in adult morphology and behavior. To gain insight into the molecular-genetic specification of reproductive behaviors and physiology, we identified genes expressed in the adult head and central nervous system that are regulated downstream of sex-specific transcription factors encoded by doublesex (dsx) and fruitless (fru). We used a microarray approach and identified 54 genes regulated downstream of dsx. Furthermore, based on these expression studies we identified new modes of DSX-regulated gene expression. We also identified 90 and 26 genes regulated in the adult head and central nervous system tissues, respectively, downstream of the sex-specific transcription factors encoded by fru. In addition, we present molecular-genetic analyses of two genes identified in our studies, calphotin (cpn) and defective proboscis extension response (dpr), and begin to describe their functional roles in male behaviors. We show that dpr and dpr-expressing cells are required for the proper timing of male courtship behaviors. |
| first_indexed | 2024-04-12T19:31:13Z |
| format | Article |
| id | doaj.art-dd6cd709ae33442198b7677d9c6e0a85 |
| institution | Directory Open Access Journal |
| issn | 1553-7390 1553-7404 |
| language | English |
| last_indexed | 2024-04-12T19:31:13Z |
| publishDate | 2007-11-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj.art-dd6cd709ae33442198b7677d9c6e0a852022-12-22T03:19:20ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042007-11-01311e21610.1371/journal.pgen.0030216Genomic and functional studies of Drosophila sex hierarchy regulated gene expression in adult head and nervous system tissues.Thomas D GoldmanMichelle N ArbeitmanThe Drosophila sex determination hierarchy controls all aspects of somatic sexual differentiation, including sex-specific differences in adult morphology and behavior. To gain insight into the molecular-genetic specification of reproductive behaviors and physiology, we identified genes expressed in the adult head and central nervous system that are regulated downstream of sex-specific transcription factors encoded by doublesex (dsx) and fruitless (fru). We used a microarray approach and identified 54 genes regulated downstream of dsx. Furthermore, based on these expression studies we identified new modes of DSX-regulated gene expression. We also identified 90 and 26 genes regulated in the adult head and central nervous system tissues, respectively, downstream of the sex-specific transcription factors encoded by fru. In addition, we present molecular-genetic analyses of two genes identified in our studies, calphotin (cpn) and defective proboscis extension response (dpr), and begin to describe their functional roles in male behaviors. We show that dpr and dpr-expressing cells are required for the proper timing of male courtship behaviors.http://europepmc.org/articles/PMC2082469?pdf=render |
| spellingShingle | Thomas D Goldman Michelle N Arbeitman Genomic and functional studies of Drosophila sex hierarchy regulated gene expression in adult head and nervous system tissues. PLoS Genetics |
| title | Genomic and functional studies of Drosophila sex hierarchy regulated gene expression in adult head and nervous system tissues. |
| title_full | Genomic and functional studies of Drosophila sex hierarchy regulated gene expression in adult head and nervous system tissues. |
| title_fullStr | Genomic and functional studies of Drosophila sex hierarchy regulated gene expression in adult head and nervous system tissues. |
| title_full_unstemmed | Genomic and functional studies of Drosophila sex hierarchy regulated gene expression in adult head and nervous system tissues. |
| title_short | Genomic and functional studies of Drosophila sex hierarchy regulated gene expression in adult head and nervous system tissues. |
| title_sort | genomic and functional studies of drosophila sex hierarchy regulated gene expression in adult head and nervous system tissues |
| url | http://europepmc.org/articles/PMC2082469?pdf=render |
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