Bone mineral density deficits in childhood cancer survivors: Pathophysiology, prevalence, screening, and management
As chemotherapy and other sophisticated treatment strategies evolve and the number of survivors of long-term childhood cancer grows, the long-term complications of treatment and the cancer itself are becoming ever more important. One of the most important but often neglected complications is osteopo...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Korean Pediatric Society
2013-02-01
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| Series: | Korean Journal of Pediatrics |
| Subjects: | |
| Online Access: | http://kjp.or.kr/upload/pdf/kjped-56-60.pdf |
| _version_ | 1818039532090556416 |
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| author | Min Jae Kang Jung Sub Lim |
| author_facet | Min Jae Kang Jung Sub Lim |
| author_sort | Min Jae Kang |
| collection | DOAJ |
| description | As chemotherapy and other sophisticated treatment strategies evolve and the number of survivors of long-term childhood cancer grows, the long-term complications of treatment and the cancer itself are becoming ever more important. One of the most important but often neglected complications is osteoporosis and increased risk of fracture during and after cancer treatment. Acquisition of optimal peak bone mass and strength during childhood and adolescence is critical to preventing osteoporosis later in life. However, most childhood cancer patients have multiple risk factors for bone mineral loss. Cancer itself, malnutrition, decreased physical activity during treatment, chemotherapeutic agents such as steroids, and radiotherapy cause bone mineral deficit. Furthermore, complications such as growth hormone deficiency and musculoskeletal deformity have negative effects on bone metabolism. Low bone mineral density is associated with fractures, skeletal deformity, pain, and substantial financial burden not only for childhood cancer survivors but also for public health care systems. Thus, it is important to monitor bone health in these patients and minimize their risk of developing osteoporosis and fragility fractures later in life. |
| first_indexed | 2024-12-10T08:00:07Z |
| format | Article |
| id | doaj.art-dd6d69eee12848fe8867eeb7cea7007b |
| institution | Directory Open Access Journal |
| issn | 1738-1061 2092-7258 |
| language | English |
| last_indexed | 2024-12-10T08:00:07Z |
| publishDate | 2013-02-01 |
| publisher | Korean Pediatric Society |
| record_format | Article |
| series | Korean Journal of Pediatrics |
| spelling | doaj.art-dd6d69eee12848fe8867eeb7cea7007b2022-12-22T01:56:48ZengKorean Pediatric SocietyKorean Journal of Pediatrics1738-10612092-72582013-02-01562606710.3345/kjp.2013.56.2.602012600053Bone mineral density deficits in childhood cancer survivors: Pathophysiology, prevalence, screening, and managementMin Jae Kang0Jung Sub Lim1Department of Pediatrics, Seoul National University Hospital, Seoul, Korea.Department of Pediatrics, Korea Cancer Center Hospital, Seoul, Korea.As chemotherapy and other sophisticated treatment strategies evolve and the number of survivors of long-term childhood cancer grows, the long-term complications of treatment and the cancer itself are becoming ever more important. One of the most important but often neglected complications is osteoporosis and increased risk of fracture during and after cancer treatment. Acquisition of optimal peak bone mass and strength during childhood and adolescence is critical to preventing osteoporosis later in life. However, most childhood cancer patients have multiple risk factors for bone mineral loss. Cancer itself, malnutrition, decreased physical activity during treatment, chemotherapeutic agents such as steroids, and radiotherapy cause bone mineral deficit. Furthermore, complications such as growth hormone deficiency and musculoskeletal deformity have negative effects on bone metabolism. Low bone mineral density is associated with fractures, skeletal deformity, pain, and substantial financial burden not only for childhood cancer survivors but also for public health care systems. Thus, it is important to monitor bone health in these patients and minimize their risk of developing osteoporosis and fragility fractures later in life.http://kjp.or.kr/upload/pdf/kjped-56-60.pdfBone mineral densityCancerFracturesRisk factors |
| spellingShingle | Min Jae Kang Jung Sub Lim Bone mineral density deficits in childhood cancer survivors: Pathophysiology, prevalence, screening, and management Korean Journal of Pediatrics Bone mineral density Cancer Fractures Risk factors |
| title | Bone mineral density deficits in childhood cancer survivors: Pathophysiology, prevalence, screening, and management |
| title_full | Bone mineral density deficits in childhood cancer survivors: Pathophysiology, prevalence, screening, and management |
| title_fullStr | Bone mineral density deficits in childhood cancer survivors: Pathophysiology, prevalence, screening, and management |
| title_full_unstemmed | Bone mineral density deficits in childhood cancer survivors: Pathophysiology, prevalence, screening, and management |
| title_short | Bone mineral density deficits in childhood cancer survivors: Pathophysiology, prevalence, screening, and management |
| title_sort | bone mineral density deficits in childhood cancer survivors pathophysiology prevalence screening and management |
| topic | Bone mineral density Cancer Fractures Risk factors |
| url | http://kjp.or.kr/upload/pdf/kjped-56-60.pdf |
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