Effect of the GSTM1 genotype on the biomarkers of exposure to polycyclic aromatic hydrocarbons: Meta-analysis
The role of glutathione S-transferase Mu 1 (GSTM1) in the biomonitoring of polycyclic aromatic hydrocarbons (PAHs) is not clear. Our purpose has been to evaluate the influence of GSTM1 genotypes on 1-hydroxypyrene (1-OHP), deoxyribonucleic acid (DNA) adducts, and micronucleus frequency in both occup...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nofer Institute of Occupational Medicine
2017-04-01
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| Series: | International Journal of Occupational Medicine and Environmental Health |
| Subjects: | |
| Online Access: | http://ijomeh.eu/Effect-of-the-GSTM1-genotype-on-the-biomarkers-of-exposure-to-polycyclic-aromatic-hydrocarbons-Meta-analysis,65310,0,2.html |
| _version_ | 1819179317620375552 |
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| author | Dandan Li Bingling Wang Guochang Feng Meng Xie Lijuan Wang Ruqin Gao |
| author_facet | Dandan Li Bingling Wang Guochang Feng Meng Xie Lijuan Wang Ruqin Gao |
| author_sort | Dandan Li |
| collection | DOAJ |
| description | The role of glutathione S-transferase Mu 1 (GSTM1) in the biomonitoring of polycyclic aromatic hydrocarbons (PAHs) is not clear. Our purpose has been to evaluate the influence of GSTM1 genotypes on 1-hydroxypyrene (1-OHP), deoxyribonucleic acid (DNA) adducts, and micronucleus frequency in both occupational and non-occupational populations of null and active GSTM1 carriers. We conducted a meta-analysis on 25 articles that met our strict inclusion criteria (11 studies on 1-OHP, 9 on DNA adducts, and 5 on the micronucleus frequency). In the case of occupationally exposed workers, micronucleus frequency was only significantly higher in the null GSTM1 carriers than in the active GSTM1 carriers. In the non-occupationally exposed general population, 1-OHP and micronucleus frequency were significantly higher in the null GSTM1 carriers. The results of Egger’s test and funnel plot analysis indicated no significant publication bias. In conclusion, GSTM1 genotypes may affect the urinary 1-OHP in the non-occupationally exposed general population, and micronucleus frequency in both occupational workers and non-occupational population. Int J Occup Med Environ Health 2017;30(2):177–201 |
| first_indexed | 2024-12-22T21:56:32Z |
| format | Article |
| id | doaj.art-dd70770e440c4037b8b953d98082015e |
| institution | Directory Open Access Journal |
| issn | 1232-1087 1896-494X |
| language | English |
| last_indexed | 2024-12-22T21:56:32Z |
| publishDate | 2017-04-01 |
| publisher | Nofer Institute of Occupational Medicine |
| record_format | Article |
| series | International Journal of Occupational Medicine and Environmental Health |
| spelling | doaj.art-dd70770e440c4037b8b953d98082015e2022-12-21T18:11:14ZengNofer Institute of Occupational MedicineInternational Journal of Occupational Medicine and Environmental Health1232-10871896-494X2017-04-0130217720110.13075/ijomeh.1896.01054Effect of the GSTM1 genotype on the biomarkers of exposure to polycyclic aromatic hydrocarbons: Meta-analysisDandan LiBingling WangGuochang FengMeng XieLijuan WangRuqin GaoThe role of glutathione S-transferase Mu 1 (GSTM1) in the biomonitoring of polycyclic aromatic hydrocarbons (PAHs) is not clear. Our purpose has been to evaluate the influence of GSTM1 genotypes on 1-hydroxypyrene (1-OHP), deoxyribonucleic acid (DNA) adducts, and micronucleus frequency in both occupational and non-occupational populations of null and active GSTM1 carriers. We conducted a meta-analysis on 25 articles that met our strict inclusion criteria (11 studies on 1-OHP, 9 on DNA adducts, and 5 on the micronucleus frequency). In the case of occupationally exposed workers, micronucleus frequency was only significantly higher in the null GSTM1 carriers than in the active GSTM1 carriers. In the non-occupationally exposed general population, 1-OHP and micronucleus frequency were significantly higher in the null GSTM1 carriers. The results of Egger’s test and funnel plot analysis indicated no significant publication bias. In conclusion, GSTM1 genotypes may affect the urinary 1-OHP in the non-occupationally exposed general population, and micronucleus frequency in both occupational workers and non-occupational population. Int J Occup Med Environ Health 2017;30(2):177–201http://ijomeh.eu/Effect-of-the-GSTM1-genotype-on-the-biomarkers-of-exposure-to-polycyclic-aromatic-hydrocarbons-Meta-analysis,65310,0,2.htmlpolymorphismmicronucleimeta-analysis1-hydroxypyreneDNA adductsGSTM1 |
| spellingShingle | Dandan Li Bingling Wang Guochang Feng Meng Xie Lijuan Wang Ruqin Gao Effect of the GSTM1 genotype on the biomarkers of exposure to polycyclic aromatic hydrocarbons: Meta-analysis International Journal of Occupational Medicine and Environmental Health polymorphism micronuclei meta-analysis 1-hydroxypyrene DNA adducts GSTM1 |
| title | Effect of the GSTM1 genotype on the biomarkers of exposure to polycyclic aromatic hydrocarbons: Meta-analysis |
| title_full | Effect of the GSTM1 genotype on the biomarkers of exposure to polycyclic aromatic hydrocarbons: Meta-analysis |
| title_fullStr | Effect of the GSTM1 genotype on the biomarkers of exposure to polycyclic aromatic hydrocarbons: Meta-analysis |
| title_full_unstemmed | Effect of the GSTM1 genotype on the biomarkers of exposure to polycyclic aromatic hydrocarbons: Meta-analysis |
| title_short | Effect of the GSTM1 genotype on the biomarkers of exposure to polycyclic aromatic hydrocarbons: Meta-analysis |
| title_sort | effect of the gstm1 genotype on the biomarkers of exposure to polycyclic aromatic hydrocarbons meta analysis |
| topic | polymorphism micronuclei meta-analysis 1-hydroxypyrene DNA adducts GSTM1 |
| url | http://ijomeh.eu/Effect-of-the-GSTM1-genotype-on-the-biomarkers-of-exposure-to-polycyclic-aromatic-hydrocarbons-Meta-analysis,65310,0,2.html |
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