Residual renal volume as a long-term independent predictive factor of developing chronic kidney disease after donor nephrectomy
Abstract To assess the long-term association between the residual renal volume and the progression of chronic kidney disease (CKD) in kidney donors following open or laparoscopic donor nephrectomy. A retrospective observational study involving 452 individuals who underwent open or laparoscopic donor...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-03-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-55499-3 |
| _version_ | 1797274617488867328 |
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| author | Thanakhom Hoontrakul Charoen Leenanupunth Mookdarat Siantong Pokket Sirisreetreerux Sith Phongkitkarn Wisoot Kongchareonsombat Kittinut Kijvikai |
| author_facet | Thanakhom Hoontrakul Charoen Leenanupunth Mookdarat Siantong Pokket Sirisreetreerux Sith Phongkitkarn Wisoot Kongchareonsombat Kittinut Kijvikai |
| author_sort | Thanakhom Hoontrakul |
| collection | DOAJ |
| description | Abstract To assess the long-term association between the residual renal volume and the progression of chronic kidney disease (CKD) in kidney donors following open or laparoscopic donor nephrectomy. A retrospective observational study involving 452 individuals who underwent open or laparoscopic donor nephrectomy at Ramathibodi Hospital, Bangkok, Thailand. The study spanned over a comprehensive 60-month monitoring period. Residual renal volume was determined through Computer Tomography. Patient characteristics, surgical techniques, donated kidney side, and estimated glomerular filtration rate (eGFR) were collected and analysed. In a multivariate analysis, a residual renal volume exceeding 50% of original volume is associated with an increased likelihood of developing CKD, with a hazard ratio (HR) of 1.675 (P < 0.05), and male gender has a hazard ratio (HR) of 4.013 (P < 0.001). Additionally, age is identified as a minor risk factor for developing CKD, with hazard ratio (HR) of 1.107 (P < 0.001). Higher residual renal volume, male gender, and older age were identified as independent risk factors for the development of CKD following open or laparoscopic donor nephrectomy during long-term follow-up. |
| first_indexed | 2024-03-07T15:00:52Z |
| format | Article |
| id | doaj.art-dd70aa8ebba14547abc883bad1cdae74 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:00:52Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-dd70aa8ebba14547abc883bad1cdae742024-03-05T19:09:20ZengNature PortfolioScientific Reports2045-23222024-03-011411610.1038/s41598-024-55499-3Residual renal volume as a long-term independent predictive factor of developing chronic kidney disease after donor nephrectomyThanakhom Hoontrakul0Charoen Leenanupunth1Mookdarat Siantong2Pokket Sirisreetreerux3Sith Phongkitkarn4Wisoot Kongchareonsombat5Kittinut Kijvikai6Faculty of Medicine, Thammasat UniversityDivision of Urology, Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol UniversityDivision of Urology, Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol UniversityDivision of Urology, Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol UniversityDepartment of Radiology, Faculty of Medicine Ramathibodi Hospital, Mahidol UniversityDivision of Urology, Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol UniversityDivision of Urology, Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol UniversityAbstract To assess the long-term association between the residual renal volume and the progression of chronic kidney disease (CKD) in kidney donors following open or laparoscopic donor nephrectomy. A retrospective observational study involving 452 individuals who underwent open or laparoscopic donor nephrectomy at Ramathibodi Hospital, Bangkok, Thailand. The study spanned over a comprehensive 60-month monitoring period. Residual renal volume was determined through Computer Tomography. Patient characteristics, surgical techniques, donated kidney side, and estimated glomerular filtration rate (eGFR) were collected and analysed. In a multivariate analysis, a residual renal volume exceeding 50% of original volume is associated with an increased likelihood of developing CKD, with a hazard ratio (HR) of 1.675 (P < 0.05), and male gender has a hazard ratio (HR) of 4.013 (P < 0.001). Additionally, age is identified as a minor risk factor for developing CKD, with hazard ratio (HR) of 1.107 (P < 0.001). Higher residual renal volume, male gender, and older age were identified as independent risk factors for the development of CKD following open or laparoscopic donor nephrectomy during long-term follow-up.https://doi.org/10.1038/s41598-024-55499-3Donor nephrectomyChronic kidney diseaseResidual renal volumeLong-term follow-up |
| spellingShingle | Thanakhom Hoontrakul Charoen Leenanupunth Mookdarat Siantong Pokket Sirisreetreerux Sith Phongkitkarn Wisoot Kongchareonsombat Kittinut Kijvikai Residual renal volume as a long-term independent predictive factor of developing chronic kidney disease after donor nephrectomy Scientific Reports Donor nephrectomy Chronic kidney disease Residual renal volume Long-term follow-up |
| title | Residual renal volume as a long-term independent predictive factor of developing chronic kidney disease after donor nephrectomy |
| title_full | Residual renal volume as a long-term independent predictive factor of developing chronic kidney disease after donor nephrectomy |
| title_fullStr | Residual renal volume as a long-term independent predictive factor of developing chronic kidney disease after donor nephrectomy |
| title_full_unstemmed | Residual renal volume as a long-term independent predictive factor of developing chronic kidney disease after donor nephrectomy |
| title_short | Residual renal volume as a long-term independent predictive factor of developing chronic kidney disease after donor nephrectomy |
| title_sort | residual renal volume as a long term independent predictive factor of developing chronic kidney disease after donor nephrectomy |
| topic | Donor nephrectomy Chronic kidney disease Residual renal volume Long-term follow-up |
| url | https://doi.org/10.1038/s41598-024-55499-3 |
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