Protective Effects of Proline–Rich Peptide in a Rat Model of Alzheimer Disease: An Electrophysiological Study
Introduction: Alzheimer disease (AD) is the most common form of dementia in the elderly that slowly destroys memory and cognitive functions. The disease has no cure and leads to significant structural and functional brain abnormalities. To facilitate the treatment of this disease, we aimed to invest...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Iran University of Medical Sciences
2017-01-01
|
| Series: | Basic and Clinical Neuroscience |
| Subjects: | |
| Online Access: | http://bcn.iums.ac.ir/browse.php?a_code=A-10-816-1&slc_lang=en&sid=1 |
| _version_ | 1797283123477610496 |
|---|---|
| author | Naser Khalaji John Sarkissian Vergine Chavushyan Vaghinak Sarkisian |
| author_facet | Naser Khalaji John Sarkissian Vergine Chavushyan Vaghinak Sarkisian |
| author_sort | Naser Khalaji |
| collection | DOAJ |
| description | Introduction: Alzheimer disease (AD) is the most common form of dementia in the elderly that slowly destroys memory and cognitive functions. The disease has no cure and leads to significant structural and functional brain abnormalities. To facilitate the treatment of this disease, we aimed to investigate proline-rich peptide (PRP-1) action of hypothalamus on hippocampal (HP) neurons and dynamics of their recovery, after intracerebroventricular (ICV) injection of amyloid-β (Aβ).
Methods: Experiments were carried out on 24 adult, male Albino rats (average weight: 230±30 g). The animals were randomly divided into 3 groups (control, Aβ, and Aβ plus PRP-1). Electrophysiological patterns of hippocampal neurons in response to stimulation of entorhinal cortex (EC) with high frequency stimulation (50 Hz) were studied.
Results: It was found that Aβ (25-35) suppresses the electrical activity of hippocampal neurons. The PRP-1 would return this activity to normal levels.
Conclusion: In general, PRP-1 has protective effect against AD-related alterations induced byamyloid peptides. This protective effect is probably due to stimulation of the immune and glia system. |
| first_indexed | 2024-03-07T17:25:39Z |
| format | Article |
| id | doaj.art-dd72ad8b5cf741f6abc319aa3991b43d |
| institution | Directory Open Access Journal |
| issn | 2008-126X 2228-7442 |
| language | English |
| last_indexed | 2024-03-07T17:25:39Z |
| publishDate | 2017-01-01 |
| publisher | Iran University of Medical Sciences |
| record_format | Article |
| series | Basic and Clinical Neuroscience |
| spelling | doaj.art-dd72ad8b5cf741f6abc319aa3991b43d2024-03-02T19:16:35ZengIran University of Medical SciencesBasic and Clinical Neuroscience2008-126X2228-74422017-01-0181512Protective Effects of Proline–Rich Peptide in a Rat Model of Alzheimer Disease: An Electrophysiological StudyNaser Khalaji0John Sarkissian1Vergine Chavushyan2Vaghinak Sarkisian3 Department of Physiology, School of Medicine, Uremia University of Medical Sciences, Uremia, Iran. Orbeli Institute of Physiology, National Academy of Sciences of the Republic of Armenia, Yerevan, Republic of Armenia. Orbeli Institute of Physiology, National Academy of Sciences of the Republic of Armenia, Yerevan, Republic of Armenia. Orbeli Institute of Physiology, National Academy of Sciences of the Republic of Armenia, Yerevan, Republic of Armenia. Introduction: Alzheimer disease (AD) is the most common form of dementia in the elderly that slowly destroys memory and cognitive functions. The disease has no cure and leads to significant structural and functional brain abnormalities. To facilitate the treatment of this disease, we aimed to investigate proline-rich peptide (PRP-1) action of hypothalamus on hippocampal (HP) neurons and dynamics of their recovery, after intracerebroventricular (ICV) injection of amyloid-β (Aβ). Methods: Experiments were carried out on 24 adult, male Albino rats (average weight: 230±30 g). The animals were randomly divided into 3 groups (control, Aβ, and Aβ plus PRP-1). Electrophysiological patterns of hippocampal neurons in response to stimulation of entorhinal cortex (EC) with high frequency stimulation (50 Hz) were studied. Results: It was found that Aβ (25-35) suppresses the electrical activity of hippocampal neurons. The PRP-1 would return this activity to normal levels. Conclusion: In general, PRP-1 has protective effect against AD-related alterations induced byamyloid peptides. This protective effect is probably due to stimulation of the immune and glia system.http://bcn.iums.ac.ir/browse.php?a_code=A-10-816-1&slc_lang=en&sid=1Hypothalamic Proline–Rich Peptide (PRP-1) Alzheimer disease Amyloid-β Hippocampus |
| spellingShingle | Naser Khalaji John Sarkissian Vergine Chavushyan Vaghinak Sarkisian Protective Effects of Proline–Rich Peptide in a Rat Model of Alzheimer Disease: An Electrophysiological Study Basic and Clinical Neuroscience Hypothalamic Proline–Rich Peptide (PRP-1) Alzheimer disease Amyloid-β Hippocampus |
| title | Protective Effects of Proline–Rich Peptide in a Rat Model of Alzheimer Disease: An Electrophysiological Study |
| title_full | Protective Effects of Proline–Rich Peptide in a Rat Model of Alzheimer Disease: An Electrophysiological Study |
| title_fullStr | Protective Effects of Proline–Rich Peptide in a Rat Model of Alzheimer Disease: An Electrophysiological Study |
| title_full_unstemmed | Protective Effects of Proline–Rich Peptide in a Rat Model of Alzheimer Disease: An Electrophysiological Study |
| title_short | Protective Effects of Proline–Rich Peptide in a Rat Model of Alzheimer Disease: An Electrophysiological Study |
| title_sort | protective effects of proline rich peptide in a rat model of alzheimer disease an electrophysiological study |
| topic | Hypothalamic Proline–Rich Peptide (PRP-1) Alzheimer disease Amyloid-β Hippocampus |
| url | http://bcn.iums.ac.ir/browse.php?a_code=A-10-816-1&slc_lang=en&sid=1 |
| work_keys_str_mv | AT naserkhalaji protectiveeffectsofprolinerichpeptideinaratmodelofalzheimerdiseaseanelectrophysiologicalstudy AT johnsarkissian protectiveeffectsofprolinerichpeptideinaratmodelofalzheimerdiseaseanelectrophysiologicalstudy AT verginechavushyan protectiveeffectsofprolinerichpeptideinaratmodelofalzheimerdiseaseanelectrophysiologicalstudy AT vaghinaksarkisian protectiveeffectsofprolinerichpeptideinaratmodelofalzheimerdiseaseanelectrophysiologicalstudy |