Current treatment landscape and emerging management options for extremity sarcoma
Malignant tumors of extremity are mostly of mesenchymal origin and arise from bone or extraskeletal soft tissue. Combination chemotherapy has greatly increased the survival of non-metastatic localized osteosarcoma and Ewing's sarcoma; however, there is conflicting evidence regarding the role of...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Cancer Research, Statistics, and Treatment |
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| Online Access: | http://www.crstonline.com/article.asp?issn=2590-3233;year=2018;volume=1;issue=2;spage=121;epage=138;aulast=Turkar |
| _version_ | 1818547851465064448 |
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| author | Siddharth Turkar |
| author_facet | Siddharth Turkar |
| author_sort | Siddharth Turkar |
| collection | DOAJ |
| description | Malignant tumors of extremity are mostly of mesenchymal origin and arise from bone or extraskeletal soft tissue. Combination chemotherapy has greatly increased the survival of non-metastatic localized osteosarcoma and Ewing's sarcoma; however, there is conflicting evidence regarding the role of neoadjuvant and adjuvant chemotherapy in soft tissue sarcoma due to the rarity and heterogeneous population. Despite intensive multimodal therapy and valiant efforts, most of the patients with relapsed and metastatic sarcoma will succumb to their disease. Molecular studies like next-generation sequencing have revealed various targetable biomarkers which can be further explored in the therapeutic landscape with specific targeted therapies. We reviewed all ongoing and completed clinical trials involving chemotherapy, targeted therapy, and immunotherapy valid for patients with extremity sarcoma. We present the current viable therapeutic options for such a cohort of patients in routine clinical practice. |
| first_indexed | 2024-12-12T08:12:11Z |
| format | Article |
| id | doaj.art-dd73896d605a4136b398783befbeed6e |
| institution | Directory Open Access Journal |
| issn | 2590-3233 2590-3225 |
| language | English |
| last_indexed | 2024-12-12T08:12:11Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Cancer Research, Statistics, and Treatment |
| spelling | doaj.art-dd73896d605a4136b398783befbeed6e2022-12-22T00:31:45ZengWolters Kluwer Medknow PublicationsCancer Research, Statistics, and Treatment2590-32332590-32252018-01-011212113810.4103/CRST.CRST_9_19Current treatment landscape and emerging management options for extremity sarcomaSiddharth TurkarMalignant tumors of extremity are mostly of mesenchymal origin and arise from bone or extraskeletal soft tissue. Combination chemotherapy has greatly increased the survival of non-metastatic localized osteosarcoma and Ewing's sarcoma; however, there is conflicting evidence regarding the role of neoadjuvant and adjuvant chemotherapy in soft tissue sarcoma due to the rarity and heterogeneous population. Despite intensive multimodal therapy and valiant efforts, most of the patients with relapsed and metastatic sarcoma will succumb to their disease. Molecular studies like next-generation sequencing have revealed various targetable biomarkers which can be further explored in the therapeutic landscape with specific targeted therapies. We reviewed all ongoing and completed clinical trials involving chemotherapy, targeted therapy, and immunotherapy valid for patients with extremity sarcoma. We present the current viable therapeutic options for such a cohort of patients in routine clinical practice.http://www.crstonline.com/article.asp?issn=2590-3233;year=2018;volume=1;issue=2;spage=121;epage=138;aulast=Turkarewing sarcomaextremityosteogenic sarcomasarcoma |
| spellingShingle | Siddharth Turkar Current treatment landscape and emerging management options for extremity sarcoma Cancer Research, Statistics, and Treatment ewing sarcoma extremity osteogenic sarcoma sarcoma |
| title | Current treatment landscape and emerging management options for extremity sarcoma |
| title_full | Current treatment landscape and emerging management options for extremity sarcoma |
| title_fullStr | Current treatment landscape and emerging management options for extremity sarcoma |
| title_full_unstemmed | Current treatment landscape and emerging management options for extremity sarcoma |
| title_short | Current treatment landscape and emerging management options for extremity sarcoma |
| title_sort | current treatment landscape and emerging management options for extremity sarcoma |
| topic | ewing sarcoma extremity osteogenic sarcoma sarcoma |
| url | http://www.crstonline.com/article.asp?issn=2590-3233;year=2018;volume=1;issue=2;spage=121;epage=138;aulast=Turkar |
| work_keys_str_mv | AT siddharthturkar currenttreatmentlandscapeandemergingmanagementoptionsforextremitysarcoma |