3D printing of polylactic acid/poly ethylene glycol/hydroxyapatite porous bone scaffolds and their biocompatibility
Polylactic acid (PLA) is a widely used biopolymer material. However, there are disadvantages such as poor toughness, poor hydrophilicity, and poor biological activity in the application process. It was modified with polyethylene glycol (PEG) and hydroxyapatite (HA).3D printing filaments of PLA/PEG/H...
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| Format: | Article |
| Language: | zho |
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Journal of Materials Engineering
2021-04-01
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| Series: | Cailiao gongcheng |
| Subjects: | |
| Online Access: | http://jme.biam.ac.cn/CN/10.11868/j.issn.1001-4381.2020.000390 |
| _version_ | 1797968730073858048 |
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| author | FAN Ze-wen ZHAO Xin-yu QIU Shuai WANG Yan GUO Jing QUAN Hui-xin XU Lan-juan |
| author_facet | FAN Ze-wen ZHAO Xin-yu QIU Shuai WANG Yan GUO Jing QUAN Hui-xin XU Lan-juan |
| author_sort | FAN Ze-wen |
| collection | DOAJ |
| description | Polylactic acid (PLA) is a widely used biopolymer material. However, there are disadvantages such as poor toughness, poor hydrophilicity, and poor biological activity in the application process. It was modified with polyethylene glycol (PEG) and hydroxyapatite (HA).3D printing filaments of PLA/PEG/HA with different mass ratios were prepared by melt blending. And by analyzing the mechanical properties, crystallization properties, thermal properties, rheological properties of PLA/PEG/HA filaments, the more suitable filaments for fused deposition modeling of 3D printing (FDM) were screened, and then the high precision mechanical samples and bioporous scaffolds with good biocompatibility, cell value-added and differentiation were 3D printed. The results show that the addition of PEG improves the toughness of PLA and lowers the melting point of PLA. The addition of HA increases the elastic modulus and cold crystallization temperature of PLA/PEG/HA composites, and HA can also improve the flowability of PLA/PEG/HA composites. SEM and fluorescent labeling results show that the porous scaffold has good biocompatibility. The successful cultivation of bioscaffolds <i>in vitro</i> cells provides potential for further exploration of bioporous scaffolds in animals, biomedicine, and customized applications. |
| first_indexed | 2024-04-11T02:50:15Z |
| format | Article |
| id | doaj.art-dd744f420b2d4a0a9ad0ca9efdc11f48 |
| institution | Directory Open Access Journal |
| issn | 1001-4381 1001-4381 |
| language | zho |
| last_indexed | 2024-04-11T02:50:15Z |
| publishDate | 2021-04-01 |
| publisher | Journal of Materials Engineering |
| record_format | Article |
| series | Cailiao gongcheng |
| spelling | doaj.art-dd744f420b2d4a0a9ad0ca9efdc11f482023-01-02T16:33:55ZzhoJournal of Materials EngineeringCailiao gongcheng1001-43811001-43812021-04-0149413514110.11868/j.issn.1001-4381.2020.000390202104153D printing of polylactic acid/poly ethylene glycol/hydroxyapatite porous bone scaffolds and their biocompatibilityFAN Ze-wen0ZHAO Xin-yu1QIU Shuai2WANG Yan3GUO Jing4QUAN Hui-xin5XU Lan-juan6School of Textile and Material Engineering, Dalian Polytechnic University, Dalian 116034, Liaoning, ChinaSchool of Textile and Material Engineering, Dalian Polytechnic University, Dalian 116034, Liaoning, ChinaSchool of Textile and Material Engineering, Dalian Polytechnic University, Dalian 116034, Liaoning, ChinaSchool of Textile and Material Engineering, Dalian Polytechnic University, Dalian 116034, Liaoning, ChinaSchool of Textile and Material Engineering, Dalian Polytechnic University, Dalian 116034, Liaoning, ChinaFirst Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning, ChinaZhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, ChinaPolylactic acid (PLA) is a widely used biopolymer material. However, there are disadvantages such as poor toughness, poor hydrophilicity, and poor biological activity in the application process. It was modified with polyethylene glycol (PEG) and hydroxyapatite (HA).3D printing filaments of PLA/PEG/HA with different mass ratios were prepared by melt blending. And by analyzing the mechanical properties, crystallization properties, thermal properties, rheological properties of PLA/PEG/HA filaments, the more suitable filaments for fused deposition modeling of 3D printing (FDM) were screened, and then the high precision mechanical samples and bioporous scaffolds with good biocompatibility, cell value-added and differentiation were 3D printed. The results show that the addition of PEG improves the toughness of PLA and lowers the melting point of PLA. The addition of HA increases the elastic modulus and cold crystallization temperature of PLA/PEG/HA composites, and HA can also improve the flowability of PLA/PEG/HA composites. SEM and fluorescent labeling results show that the porous scaffold has good biocompatibility. The successful cultivation of bioscaffolds <i>in vitro</i> cells provides potential for further exploration of bioporous scaffolds in animals, biomedicine, and customized applications.http://jme.biam.ac.cn/CN/10.11868/j.issn.1001-4381.2020.000390polylactic acid3d printingporous scaffoldbiocompatibility |
| spellingShingle | FAN Ze-wen ZHAO Xin-yu QIU Shuai WANG Yan GUO Jing QUAN Hui-xin XU Lan-juan 3D printing of polylactic acid/poly ethylene glycol/hydroxyapatite porous bone scaffolds and their biocompatibility Cailiao gongcheng polylactic acid 3d printing porous scaffold biocompatibility |
| title | 3D printing of polylactic acid/poly ethylene glycol/hydroxyapatite porous bone scaffolds and their biocompatibility |
| title_full | 3D printing of polylactic acid/poly ethylene glycol/hydroxyapatite porous bone scaffolds and their biocompatibility |
| title_fullStr | 3D printing of polylactic acid/poly ethylene glycol/hydroxyapatite porous bone scaffolds and their biocompatibility |
| title_full_unstemmed | 3D printing of polylactic acid/poly ethylene glycol/hydroxyapatite porous bone scaffolds and their biocompatibility |
| title_short | 3D printing of polylactic acid/poly ethylene glycol/hydroxyapatite porous bone scaffolds and their biocompatibility |
| title_sort | 3d printing of polylactic acid poly ethylene glycol hydroxyapatite porous bone scaffolds and their biocompatibility |
| topic | polylactic acid 3d printing porous scaffold biocompatibility |
| url | http://jme.biam.ac.cn/CN/10.11868/j.issn.1001-4381.2020.000390 |
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