The diagnostic and prognostic value of D-dimer in different types of aortic dissection
Abstract Objective To evaluate the serum D-dimer level and its diagnostic and prognostic predictive value in patients with different types of aortic dissection. Methods Eighty-four aortic dissection patients who were diagnosed clinically in our hospital from January 2017 to January 2021 were selecte...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | Journal of Cardiothoracic Surgery |
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| Online Access: | https://doi.org/10.1186/s13019-022-01940-5 |
| _version_ | 1828433655047913472 |
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| author | Deli Wang Jie Chen Jianhua Sun Hongmei Chen Fang Li Junfeng Wang |
| author_facet | Deli Wang Jie Chen Jianhua Sun Hongmei Chen Fang Li Junfeng Wang |
| author_sort | Deli Wang |
| collection | DOAJ |
| description | Abstract Objective To evaluate the serum D-dimer level and its diagnostic and prognostic predictive value in patients with different types of aortic dissection. Methods Eighty-four aortic dissection patients who were diagnosed clinically in our hospital from January 2017 to January 2021 were selected for the study. All patients were divided into Stanford type A (39 cases) and Stanford type B (45 cases) groups. The serum D-dimer level was detected at 1 h, 6 h, 12 h, 24 h, and 72 h after admission to the hospital, and its expression level with different types of aortic dissection was analyzed. The relationship between D-dimer and the prognosis of patients was also analyzed. Results The serum D-dimer levels of patients in group A were significantly higher than those in group B at 6 h, 12 h, 24 h, and 72 h after admission, and the differences were statistically significant. In group A, 16 patients died, and 23 patients survived, while in group B, 18 patients died, and 27 patients survived. The serum D-dimer level of the dead and surviving patients in group A was significantly higher than that of group B, and the serum D-dimer level of dead patients in groups A and B was significantly higher than that of surviving patients. For diagnostic value, the AUC was 0.89, sensitivity was 76.92%, specificity was 90.00% in group A, and the AUC was 0.82, sensitivity was 71.11%, and specificity was 85.00% in group B. For the prognostic predicted value, the AUC was 0.74 in group A, while the AUC was 0.69 in group B. Conclusions D-dimer has different serum levels in different types of aortic dissection patients, with higher levels in Stanford A. Serum D-dimer levels may be used as a better biomarker to diagnose the two types of aortic dissection and play an important role in patient prognostic prediction, especially Stanford type A. |
| first_indexed | 2024-12-10T18:38:37Z |
| format | Article |
| id | doaj.art-dd75de8eb41140549589c51b29a75177 |
| institution | Directory Open Access Journal |
| issn | 1749-8090 |
| language | English |
| last_indexed | 2024-12-10T18:38:37Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiothoracic Surgery |
| spelling | doaj.art-dd75de8eb41140549589c51b29a751772022-12-22T01:37:43ZengBMCJournal of Cardiothoracic Surgery1749-80902022-08-011711710.1186/s13019-022-01940-5The diagnostic and prognostic value of D-dimer in different types of aortic dissectionDeli Wang0Jie Chen1Jianhua Sun2Hongmei Chen3Fang Li4Junfeng Wang5Department of General Surgery, 904th Hospital of Joint Logistic Support Force of PLA (Suzhou)Department of General Surgery, 904th Hospital of Joint Logistic Support Force of PLA (Suzhou)Department of General Surgery, 904th Hospital of Joint Logistic Support Force of PLA (Suzhou)Department of Nursing, 904th Hospital of Joint Logistic Support Force of PLA (Suzhou)Department of General Surgery, 904th Hospital of Joint Logistic Support Force of PLA (Suzhou)Department of General Surgery, 904th Hospital of Joint Logistic Support Force of PLA (Suzhou)Abstract Objective To evaluate the serum D-dimer level and its diagnostic and prognostic predictive value in patients with different types of aortic dissection. Methods Eighty-four aortic dissection patients who were diagnosed clinically in our hospital from January 2017 to January 2021 were selected for the study. All patients were divided into Stanford type A (39 cases) and Stanford type B (45 cases) groups. The serum D-dimer level was detected at 1 h, 6 h, 12 h, 24 h, and 72 h after admission to the hospital, and its expression level with different types of aortic dissection was analyzed. The relationship between D-dimer and the prognosis of patients was also analyzed. Results The serum D-dimer levels of patients in group A were significantly higher than those in group B at 6 h, 12 h, 24 h, and 72 h after admission, and the differences were statistically significant. In group A, 16 patients died, and 23 patients survived, while in group B, 18 patients died, and 27 patients survived. The serum D-dimer level of the dead and surviving patients in group A was significantly higher than that of group B, and the serum D-dimer level of dead patients in groups A and B was significantly higher than that of surviving patients. For diagnostic value, the AUC was 0.89, sensitivity was 76.92%, specificity was 90.00% in group A, and the AUC was 0.82, sensitivity was 71.11%, and specificity was 85.00% in group B. For the prognostic predicted value, the AUC was 0.74 in group A, while the AUC was 0.69 in group B. Conclusions D-dimer has different serum levels in different types of aortic dissection patients, with higher levels in Stanford A. Serum D-dimer levels may be used as a better biomarker to diagnose the two types of aortic dissection and play an important role in patient prognostic prediction, especially Stanford type A.https://doi.org/10.1186/s13019-022-01940-5D-dimerDiagnosticPrognosticAortic dissectionBiomarker |
| spellingShingle | Deli Wang Jie Chen Jianhua Sun Hongmei Chen Fang Li Junfeng Wang The diagnostic and prognostic value of D-dimer in different types of aortic dissection Journal of Cardiothoracic Surgery D-dimer Diagnostic Prognostic Aortic dissection Biomarker |
| title | The diagnostic and prognostic value of D-dimer in different types of aortic dissection |
| title_full | The diagnostic and prognostic value of D-dimer in different types of aortic dissection |
| title_fullStr | The diagnostic and prognostic value of D-dimer in different types of aortic dissection |
| title_full_unstemmed | The diagnostic and prognostic value of D-dimer in different types of aortic dissection |
| title_short | The diagnostic and prognostic value of D-dimer in different types of aortic dissection |
| title_sort | diagnostic and prognostic value of d dimer in different types of aortic dissection |
| topic | D-dimer Diagnostic Prognostic Aortic dissection Biomarker |
| url | https://doi.org/10.1186/s13019-022-01940-5 |
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