Effect of Salvia Officinalis vaginal cream and clotrimazole vaginal cream on the Improvement of clinical signs of candida vaginitis in diabetic women
Introduction: Vaginitis is the most common problem of gynecological diseases. Among the types of vaginitis, Candida is the second most common cause of vaginitis in women. Diabetes is known to be a leading cause of vaginal fungal disease. Conventional treatment of Candida infection is clotrimazole va...
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| Format: | Article |
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Mashhad University of Medical Sciences
2020-01-01
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| Series: | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
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| Online Access: | https://ijogi.mums.ac.ir/article_14954_f055f0c94a6f992e4708cdc19178b9db.pdf |
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| author | Raha Pirouzmand Mahin Tafazoli Hasan Rakhshande Ali Naseri Farideh Akhlaghi MohammadTaghi Shakeri Mahmoud Parian |
| author_facet | Raha Pirouzmand Mahin Tafazoli Hasan Rakhshande Ali Naseri Farideh Akhlaghi MohammadTaghi Shakeri Mahmoud Parian |
| author_sort | Raha Pirouzmand |
| collection | DOAJ |
| description | Introduction: Vaginitis is the most common problem of gynecological diseases. Among the types of vaginitis, Candida is the second most common cause of vaginitis in women. Diabetes is known to be a leading cause of vaginal fungal disease. Conventional treatment of Candida infection is clotrimazole vaginal cream. But this drug has the side effects including redness, burning, vaginal irritation and rash. Antifungal and hypoglycemic effects of Salvia Officinalis extract have been demonstrated in laboratory and clinical studies. This study was performed with aim to compare the effect of Salvia Officinalis vaginal cream with clotrimazole vaginal cream on treatment of Candida vaginitis in diabetic women.
Methods: This randomized clinical trial study was performed on 68 patients with vaginal candidiasis in Mashhad in 2018-2019. 34 patients were placed in Salvia Officinalis and 34 in clotrimazole group. Vulvovaginal candidiasis was diagnosed by clinical symptoms and wet test, and culture in Sabrouraud dextrose agar. Vaginal Salvia officinalis cream and the Vaginal Cream Clotrimazole were administered one applicator every night for 7 nights. Follow-up was done 1 ± 7 days later. Data collection was done by the checklist of individual information and recording the signs and observations. Data were analyzed using SPSS software (version 21), and independent t-test, Chi-square, Mann-Whitney, McNemar and Wilcoxon tests. P<0.05 was considered statistically significant.
Results: There was statistically significant difference in Salvia Officinalis discharge in the salvia group compared to clotrimazole group (p <0.001). Whereas the other improving symptoms such as irritation of the vulva (P = 0.0317), itching (P = 0.093), burning (P = 0.383), post-couital pain (P = 0.067) were not significantly different between two groups.
Conclusion: Both Salvia Officinalis and clotrimazole cream improved clinical symptoms of Vulvovaginal candidiasis, and treatment effects of these two drugs are similar. |
| first_indexed | 2024-04-11T23:03:08Z |
| format | Article |
| id | doaj.art-dd7757adad5f497e9ce524d061f0b1df |
| institution | Directory Open Access Journal |
| issn | 1680-2993 2008-2363 |
| language | fas |
| last_indexed | 2024-04-11T23:03:08Z |
| publishDate | 2020-01-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
| spelling | doaj.art-dd7757adad5f497e9ce524d061f0b1df2022-12-22T03:58:04ZfasMashhad University of Medical SciencesMajallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān1680-29932008-23632020-01-012211566510.22038/ijogi.2020.1495414954Effect of Salvia Officinalis vaginal cream and clotrimazole vaginal cream on the Improvement of clinical signs of candida vaginitis in diabetic womenRaha Pirouzmand0Mahin Tafazoli1Hasan Rakhshande2Ali Naseri3Farideh Akhlaghi4MohammadTaghi Shakeri5Mahmoud Parian6M.Sc. Student of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.Assistant Professor, Department of Midwifery, Nursing and Midwifery Care Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.Assistant Professor, Department of Pharmacology, Medicinal Plants Pharmacology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Associate Professor, Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Professor, Department of Obstetrics and Gynecology, Women’s Health Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Professor, Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.M.Sc. in Parasitology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Introduction: Vaginitis is the most common problem of gynecological diseases. Among the types of vaginitis, Candida is the second most common cause of vaginitis in women. Diabetes is known to be a leading cause of vaginal fungal disease. Conventional treatment of Candida infection is clotrimazole vaginal cream. But this drug has the side effects including redness, burning, vaginal irritation and rash. Antifungal and hypoglycemic effects of Salvia Officinalis extract have been demonstrated in laboratory and clinical studies. This study was performed with aim to compare the effect of Salvia Officinalis vaginal cream with clotrimazole vaginal cream on treatment of Candida vaginitis in diabetic women. Methods: This randomized clinical trial study was performed on 68 patients with vaginal candidiasis in Mashhad in 2018-2019. 34 patients were placed in Salvia Officinalis and 34 in clotrimazole group. Vulvovaginal candidiasis was diagnosed by clinical symptoms and wet test, and culture in Sabrouraud dextrose agar. Vaginal Salvia officinalis cream and the Vaginal Cream Clotrimazole were administered one applicator every night for 7 nights. Follow-up was done 1 ± 7 days later. Data collection was done by the checklist of individual information and recording the signs and observations. Data were analyzed using SPSS software (version 21), and independent t-test, Chi-square, Mann-Whitney, McNemar and Wilcoxon tests. P<0.05 was considered statistically significant. Results: There was statistically significant difference in Salvia Officinalis discharge in the salvia group compared to clotrimazole group (p <0.001). Whereas the other improving symptoms such as irritation of the vulva (P = 0.0317), itching (P = 0.093), burning (P = 0.383), post-couital pain (P = 0.067) were not significantly different between two groups. Conclusion: Both Salvia Officinalis and clotrimazole cream improved clinical symptoms of Vulvovaginal candidiasis, and treatment effects of these two drugs are similar.https://ijogi.mums.ac.ir/article_14954_f055f0c94a6f992e4708cdc19178b9db.pdfdiabetessalvia officinalisvulvovaginit candidiasis |
| spellingShingle | Raha Pirouzmand Mahin Tafazoli Hasan Rakhshande Ali Naseri Farideh Akhlaghi MohammadTaghi Shakeri Mahmoud Parian Effect of Salvia Officinalis vaginal cream and clotrimazole vaginal cream on the Improvement of clinical signs of candida vaginitis in diabetic women Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān diabetes salvia officinalis vulvovaginit candidiasis |
| title | Effect of Salvia Officinalis vaginal cream and clotrimazole vaginal cream on the Improvement of clinical signs of candida vaginitis in diabetic women |
| title_full | Effect of Salvia Officinalis vaginal cream and clotrimazole vaginal cream on the Improvement of clinical signs of candida vaginitis in diabetic women |
| title_fullStr | Effect of Salvia Officinalis vaginal cream and clotrimazole vaginal cream on the Improvement of clinical signs of candida vaginitis in diabetic women |
| title_full_unstemmed | Effect of Salvia Officinalis vaginal cream and clotrimazole vaginal cream on the Improvement of clinical signs of candida vaginitis in diabetic women |
| title_short | Effect of Salvia Officinalis vaginal cream and clotrimazole vaginal cream on the Improvement of clinical signs of candida vaginitis in diabetic women |
| title_sort | effect of salvia officinalis vaginal cream and clotrimazole vaginal cream on the improvement of clinical signs of candida vaginitis in diabetic women |
| topic | diabetes salvia officinalis vulvovaginit candidiasis |
| url | https://ijogi.mums.ac.ir/article_14954_f055f0c94a6f992e4708cdc19178b9db.pdf |
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