New STAT3 inhibitor through biotransformation of celastrol by Streptomyces olivaceus CICC 23628

New STAT3 inhibitor through biotransformation of celastrol by Streptomyces olivaceus CICC 23628

In this study, celastrol (CEL) microbial transformation was performed by Streptomyces olivaceus CICC 23628 for the first time. Two new friedelanes derivatives (CEL-1 and CEL-2) as metabolites were isolated, and their structures were elucidated based on the NMR and HR-MS analysis. Then we investigate...

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Bibliographic Details
Main Authors: Yaqian Feng, Peipei Chen, Chuyue Huang, Hailan Chen, Ruolan Fan, Lu Wang, Shaohua Xu, Wen Xu, Zhimin Fan, Wei Xu
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Arabian Journal of Chemistry
Subjects:
Celastrol derivatives
Biotransformation
STAT3 inhibitor
Anti-tumor
Cancer organoid
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535222007729

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http://www.sciencedirect.com/science/article/pii/S1878535222007729

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