Targeting Tyro3, Axl and MerTK (TAM receptors): implications for macrophages in the tumor microenvironment

Targeting Tyro3, Axl and MerTK (TAM receptors): implications for macrophages in the tumor microenvironment

Abstract Tumor-associated macrophages are an abundant cell type in the tumor microenvironment. These macrophages serve as a promising target for treatment of cancer due to their roles in promoting cancer progression and simultaneous immunosuppression. The TAM receptors (Tyro3, Axl and MerTK) are pro...

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Bibliographic Details
Main Authors: Kayla V. Myers, Sarah R. Amend, Kenneth J. Pienta
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Molecular Cancer
Subjects:
Macrophage
TAM receptors
Tyro3
Axl
MerTK
Efferocytosis
Online Access:http://link.springer.com/article/10.1186/s12943-019-1022-2

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