Solubility Enhanced Formulation Approaches to Overcome Oral Delivery Obstacles of PROTACs

Solubility Enhanced Formulation Approaches to Overcome Oral Delivery Obstacles of PROTACs

PROteolysis TArgeting Chimaeras (PROTACs) offer new opportunities in modern medicine by targeting proteins that are undruggable to classic inhibitors. However, due to their hydrophobic structure, PROTACs typically suffer from low solubility, and oral bioavailability remains challenging. At the same...

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Bibliographic Details
Main Authors:	Florian Pöstges, Kevin Kayser, Jan Appelhaus, Marius Monschke, Michael Gütschow, Christian Steinebach, Karl G. Wagner
Format:	Article
Language:	English
Published:	MDPI AG 2023-01-01
Series:	Pharmaceutics
Subjects:	PROTAC ARCC-4 amorphous solid dispersion vacuum compression molding dissolution supersaturation
Online Access:	https://www.mdpi.com/1999-4923/15/1/156

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