A widespread single amino acid mutation in AcrA reduces tigecycline susceptibility in Klebsiella pneumoniae

A widespread single amino acid mutation in AcrA reduces tigecycline susceptibility in Klebsiella pneumoniae

ABSTRACT Whole-genome sequencing of a clinical tigecycline non-susceptible Klebsiella pneumoniae strain reveals a novel T188A mutation in AcrA, raising awareness on its role in tigecycline resistance. Through structural analysis of AcrAB-TolC in Escherichia coli that is highly homologous to K. pneum...

Full description

Bibliographic Details
Main Authors: Yingchao Xu, Wenjia Wang, Wenya Su, Mingyu Wang, Hai Xu, Xuhua Zhang, Ling Li
Format: Article
Language:English
Published: American Society for Microbiology 2024-01-01
Series:Microbiology Spectrum
Subjects:
tigecycline non-susceptibility
Klebsiella pneumoniae
AcrA mutation
resistance-nodulation-division (RND) pump
sequence types
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02030-23

Similar Items

Similar Items