A widespread single amino acid mutation in AcrA reduces tigecycline susceptibility in Klebsiella pneumoniae

A widespread single amino acid mutation in AcrA reduces tigecycline susceptibility in Klebsiella pneumoniae

ABSTRACT Whole-genome sequencing of a clinical tigecycline non-susceptible Klebsiella pneumoniae strain reveals a novel T188A mutation in AcrA, raising awareness on its role in tigecycline resistance. Through structural analysis of AcrAB-TolC in Escherichia coli that is highly homologous to K. pneum...

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Bibliographische Detailangaben
Hauptverfasser: Yingchao Xu, Wenjia Wang, Wenya Su, Mingyu Wang, Hai Xu, Xuhua Zhang, Ling Li
Format: Artikel
Sprache:English
Veröffentlicht: American Society for Microbiology 2024-01-01
Schriftenreihe:Microbiology Spectrum
Schlagworte:
tigecycline non-susceptibility
Klebsiella pneumoniae
AcrA mutation
resistance-nodulation-division (RND) pump
sequence types
Online Zugang:https://journals.asm.org/doi/10.1128/spectrum.02030-23

Online

https://journals.asm.org/doi/10.1128/spectrum.02030-23

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