A widespread single amino acid mutation in AcrA reduces tigecycline susceptibility in Klebsiella pneumoniae

ABSTRACT Whole-genome sequencing of a clinical tigecycline non-susceptible Klebsiella pneumoniae strain reveals a novel T188A mutation in AcrA, raising awareness on its role in tigecycline resistance. Through structural analysis of AcrAB-TolC in Escherichia coli that is highly homologous to K. pneum...

詳細記述

書誌詳細
主要な著者: Yingchao Xu, Wenjia Wang, Wenya Su, Mingyu Wang, Hai Xu, Xuhua Zhang, Ling Li
フォーマット: 論文
言語:English
出版事項: American Society for Microbiology 2024-01-01
シリーズ:Microbiology Spectrum
主題:
オンライン・アクセス:https://journals.asm.org/doi/10.1128/spectrum.02030-23