YAP Attenuates CD8 T Cell-Mediated Anti-tumor Response
YAP is a transcriptional coactivator of the Hippo signaling pathway that has largely been studied for its role in the regulation of organ size during development. Several studies have shown that YAP is upregulated in cancer cells, and more recently in the T regulatory (Treg) subset of CD4+ cells. Th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-04-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.00580/full |
| _version_ | 1818851529442983936 |
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| author | Andriana Lebid Liam Chung Drew M. Pardoll Fan Pan |
| author_facet | Andriana Lebid Liam Chung Drew M. Pardoll Fan Pan |
| author_sort | Andriana Lebid |
| collection | DOAJ |
| description | YAP is a transcriptional coactivator of the Hippo signaling pathway that has largely been studied for its role in the regulation of organ size during development. Several studies have shown that YAP is upregulated in cancer cells, and more recently in the T regulatory (Treg) subset of CD4+ cells. These observations suggest that the transcriptional co-activator may promote tumor persistence and progression. Here, we report that YAP also plays an immunoinhibitory role in CD8 T cells, especially in activated cytotoxic cells usually found in the tumor microenvironment. Our findings add further rationale for the development and use of pharmacologic inhibitors of YAP to treat cancer. |
| first_indexed | 2024-12-19T07:06:28Z |
| format | Article |
| id | doaj.art-dd7f726e95fc49b081623008e9387c13 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-19T07:06:28Z |
| publishDate | 2020-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-dd7f726e95fc49b081623008e9387c132022-12-21T20:31:17ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-04-011110.3389/fimmu.2020.00580524805YAP Attenuates CD8 T Cell-Mediated Anti-tumor ResponseAndriana LebidLiam ChungDrew M. PardollFan PanYAP is a transcriptional coactivator of the Hippo signaling pathway that has largely been studied for its role in the regulation of organ size during development. Several studies have shown that YAP is upregulated in cancer cells, and more recently in the T regulatory (Treg) subset of CD4+ cells. These observations suggest that the transcriptional co-activator may promote tumor persistence and progression. Here, we report that YAP also plays an immunoinhibitory role in CD8 T cells, especially in activated cytotoxic cells usually found in the tumor microenvironment. Our findings add further rationale for the development and use of pharmacologic inhibitors of YAP to treat cancer.https://www.frontiersin.org/article/10.3389/fimmu.2020.00580/fullCD8 T cellYAPtumorimmunesuppressionhippo |
| spellingShingle | Andriana Lebid Liam Chung Drew M. Pardoll Fan Pan YAP Attenuates CD8 T Cell-Mediated Anti-tumor Response Frontiers in Immunology CD8 T cell YAP tumor immunesuppression hippo |
| title | YAP Attenuates CD8 T Cell-Mediated Anti-tumor Response |
| title_full | YAP Attenuates CD8 T Cell-Mediated Anti-tumor Response |
| title_fullStr | YAP Attenuates CD8 T Cell-Mediated Anti-tumor Response |
| title_full_unstemmed | YAP Attenuates CD8 T Cell-Mediated Anti-tumor Response |
| title_short | YAP Attenuates CD8 T Cell-Mediated Anti-tumor Response |
| title_sort | yap attenuates cd8 t cell mediated anti tumor response |
| topic | CD8 T cell YAP tumor immunesuppression hippo |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.00580/full |
| work_keys_str_mv | AT andrianalebid yapattenuatescd8tcellmediatedantitumorresponse AT liamchung yapattenuatescd8tcellmediatedantitumorresponse AT drewmpardoll yapattenuatescd8tcellmediatedantitumorresponse AT fanpan yapattenuatescd8tcellmediatedantitumorresponse |