Evaluating the Clinical Efficacy of Zoledronic Acid in the Prevention and Treatment of Osteoporosis in Postmenopausal Women, Compared with Conventional Medications
Background: Due to the development of drugs, regarding this matter that customers of health services are unable to assess the clinical and financial aspects of medical technologies, evaluating the clinical efficacy of drugs is very important. This study aimed to evaluate the clinical efficacy of zol...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2015-02-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/3294 |
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| author | Fatemeh Rostami-Golmohammadi Ali Akbari-Sari Shekoufeh Nikfar Mahnaz Abbasi Batoul Ahmadi Ali Kazemi-Kariani |
| author_facet | Fatemeh Rostami-Golmohammadi Ali Akbari-Sari Shekoufeh Nikfar Mahnaz Abbasi Batoul Ahmadi Ali Kazemi-Kariani |
| author_sort | Fatemeh Rostami-Golmohammadi |
| collection | DOAJ |
| description | Background: Due to the development of drugs, regarding this matter that customers of health services are unable to assess the clinical and financial aspects of medical technologies, evaluating the clinical efficacy of drugs is very important. This study aimed to evaluate the clinical efficacy of zoledronic acid in the prevention and treatment of postmenopausal osteoporosis.
Methods: In this systematic review, the Cochrane, PubMed and Google scholar databases were searched using the keywords: “bone mineral density, male osteoporosis, zoledronic acid postmenopausal women osteoporosis”. Inclusion criteria were all menopausal women at risk of or suffering from osteoporosis that used zoledronic acid, at least once, for the prevention or treatment of osteoporosis. Desired outcomes included reduced bone fractures, bone resorption and bone turnover markers, increased bone density, and significant improvement in health-related quality of life in patients with a fracture. The included studies were randomized clinical trials in English language.
Findings: Using zoledronic acid significantly increased bone marrow density (BMD) at the total hip, lumbar spine, femoral neck, hip trochanter, and the distal radius; it reduced the incidence of hip fractures, morphometric vertebral fractures, vertebral fractures, any clinical fracture, clinical vertebral fractures, and risk of non-vertebral fracture; also, decreased bone turnover markers in the intervention group compared with the controls.
Conclusion: According to safety and clinical effectiveness of zoledronic acid, using this medication in the prevention and treatment of osteoporosis in postmenopausal women is recommended. |
| first_indexed | 2024-03-12T06:22:24Z |
| format | Article |
| id | doaj.art-dd7fe1e7d7bd4c8887f6675afa104c23 |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T06:22:24Z |
| publishDate | 2015-02-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-dd7fe1e7d7bd4c8887f6675afa104c232023-09-03T02:11:05ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2015-02-0132312210421231752Evaluating the Clinical Efficacy of Zoledronic Acid in the Prevention and Treatment of Osteoporosis in Postmenopausal Women, Compared with Conventional MedicationsFatemeh Rostami-Golmohammadi0Ali Akbari-Sari1Shekoufeh Nikfar2Mahnaz Abbasi3Batoul Ahmadi4Ali Kazemi-Kariani5MSc Student, Department of Health Economics, School of Health, Tehran University of Medical Sciences, Tehran, IranAssociate Professor, Department of Health Management and Economics, School of Health, Tehran University of Medical Sciences, Tehran, IranAssistant Professor, Food and Drug Administration, Ministry of Health and Medical Education, Tehran, IranAssociate Professor, Metabolic Research Center, Department of Rheumatology, Qazvin University of Medical Sciences, Qazvin, Iran- Assistant Professor, Department of Health Management and Economics, School of Health, Tehran University of Medical Sciences, Tehran, Iran- PhD Student, Department of Health Economics, School of Health, Tehran University of Medical Sciences, Tehran, IranBackground: Due to the development of drugs, regarding this matter that customers of health services are unable to assess the clinical and financial aspects of medical technologies, evaluating the clinical efficacy of drugs is very important. This study aimed to evaluate the clinical efficacy of zoledronic acid in the prevention and treatment of postmenopausal osteoporosis. Methods: In this systematic review, the Cochrane, PubMed and Google scholar databases were searched using the keywords: “bone mineral density, male osteoporosis, zoledronic acid postmenopausal women osteoporosis”. Inclusion criteria were all menopausal women at risk of or suffering from osteoporosis that used zoledronic acid, at least once, for the prevention or treatment of osteoporosis. Desired outcomes included reduced bone fractures, bone resorption and bone turnover markers, increased bone density, and significant improvement in health-related quality of life in patients with a fracture. The included studies were randomized clinical trials in English language. Findings: Using zoledronic acid significantly increased bone marrow density (BMD) at the total hip, lumbar spine, femoral neck, hip trochanter, and the distal radius; it reduced the incidence of hip fractures, morphometric vertebral fractures, vertebral fractures, any clinical fracture, clinical vertebral fractures, and risk of non-vertebral fracture; also, decreased bone turnover markers in the intervention group compared with the controls. Conclusion: According to safety and clinical effectiveness of zoledronic acid, using this medication in the prevention and treatment of osteoporosis in postmenopausal women is recommended.http://jims.mui.ac.ir/index.php/jims/article/view/3294Clinical effectivenessZoledronic acidOsteoporosisMenopause |
| spellingShingle | Fatemeh Rostami-Golmohammadi Ali Akbari-Sari Shekoufeh Nikfar Mahnaz Abbasi Batoul Ahmadi Ali Kazemi-Kariani Evaluating the Clinical Efficacy of Zoledronic Acid in the Prevention and Treatment of Osteoporosis in Postmenopausal Women, Compared with Conventional Medications مجله دانشکده پزشکی اصفهان Clinical effectiveness Zoledronic acid Osteoporosis Menopause |
| title | Evaluating the Clinical Efficacy of Zoledronic Acid in the Prevention and Treatment of Osteoporosis in Postmenopausal Women, Compared with Conventional Medications |
| title_full | Evaluating the Clinical Efficacy of Zoledronic Acid in the Prevention and Treatment of Osteoporosis in Postmenopausal Women, Compared with Conventional Medications |
| title_fullStr | Evaluating the Clinical Efficacy of Zoledronic Acid in the Prevention and Treatment of Osteoporosis in Postmenopausal Women, Compared with Conventional Medications |
| title_full_unstemmed | Evaluating the Clinical Efficacy of Zoledronic Acid in the Prevention and Treatment of Osteoporosis in Postmenopausal Women, Compared with Conventional Medications |
| title_short | Evaluating the Clinical Efficacy of Zoledronic Acid in the Prevention and Treatment of Osteoporosis in Postmenopausal Women, Compared with Conventional Medications |
| title_sort | evaluating the clinical efficacy of zoledronic acid in the prevention and treatment of osteoporosis in postmenopausal women compared with conventional medications |
| topic | Clinical effectiveness Zoledronic acid Osteoporosis Menopause |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/3294 |
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