Intravenous theophylline is the most effective intervention to prolong EEG seizure duration in patients undergoing electroconvulsive therapy
Abstract Background Seizure duration in electroconvulsive therapy (ECT) is positively related with patients’ outcome. This study sought to investigate the impact of anesthetic management on seizure duration, and the impact of selected drugs (theophylline, remifentanil, S-ketamine) on seizure duratio...
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| Format: | Article |
| Language: | English |
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BMC
2017-08-01
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| Series: | BMC Anesthesiology |
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| Online Access: | http://link.springer.com/article/10.1186/s12871-017-0412-5 |
| _version_ | 1818972556054495232 |
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| author | Alexander Tzabazis Michaela E. Wiernik Jan Wielopolski Wolfgang Sperling Harald Ihmsen Hubert J. Schmitt Tino Münster |
| author_facet | Alexander Tzabazis Michaela E. Wiernik Jan Wielopolski Wolfgang Sperling Harald Ihmsen Hubert J. Schmitt Tino Münster |
| author_sort | Alexander Tzabazis |
| collection | DOAJ |
| description | Abstract Background Seizure duration in electroconvulsive therapy (ECT) is positively related with patients’ outcome. This study sought to investigate the impact of anesthetic management on seizure duration, and the impact of selected drugs (theophylline, remifentanil, S-ketamine) on seizure duration. Methods Retrospective analysis of all patients undergoing ECT at our institution from January 2011 to April 2012 was performed based on electronic medical chart and review of existing quality improvement data. Patient data (N = 78), including gender, age, height, weight, and administered drugs, energy levels, and electroencephalic seizure duration were analyzed. Statistical analysis was performed using a generalized linear model. Results A total of 78 patients (male = 39, female = 39, age 51 ± 12 years) were included. Average number of session was 10 ± 6 (1–30). In our patient population, theophylline administration was the only parameter, which significantly prolonged seizure duration, whereas S-ketamine, remifentanil, thiopental, age, sex, session or energy level had no significant effect. Conclusion Theophylline can be a useful adjunct for patients with inadequate seizure duration. If there is a concomitant beneficial effect on patients’ outcome needs to be investigated in further studies. |
| first_indexed | 2024-12-20T15:10:08Z |
| format | Article |
| id | doaj.art-dd8101f017f342ebbdfb94c208bee2c6 |
| institution | Directory Open Access Journal |
| issn | 1471-2253 |
| language | English |
| last_indexed | 2024-12-20T15:10:08Z |
| publishDate | 2017-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Anesthesiology |
| spelling | doaj.art-dd8101f017f342ebbdfb94c208bee2c62022-12-21T19:36:21ZengBMCBMC Anesthesiology1471-22532017-08-011711510.1186/s12871-017-0412-5Intravenous theophylline is the most effective intervention to prolong EEG seizure duration in patients undergoing electroconvulsive therapyAlexander Tzabazis0Michaela E. Wiernik1Jan Wielopolski2Wolfgang Sperling3Harald Ihmsen4Hubert J. Schmitt5Tino Münster6Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, School of MedicineDepartment of Anesthesiology, University Hospital of ErlangenDepartment of Psychiatry and Psychotherapy, University Hospital ZürichDepartment of Psychiatry, University Hospital of ErlangenDepartment of Anesthesiology, University Hospital of ErlangenDepartment of Anesthesiology, University Hospital of ErlangenDepartment of Anesthesiology, University Hospital of ErlangenAbstract Background Seizure duration in electroconvulsive therapy (ECT) is positively related with patients’ outcome. This study sought to investigate the impact of anesthetic management on seizure duration, and the impact of selected drugs (theophylline, remifentanil, S-ketamine) on seizure duration. Methods Retrospective analysis of all patients undergoing ECT at our institution from January 2011 to April 2012 was performed based on electronic medical chart and review of existing quality improvement data. Patient data (N = 78), including gender, age, height, weight, and administered drugs, energy levels, and electroencephalic seizure duration were analyzed. Statistical analysis was performed using a generalized linear model. Results A total of 78 patients (male = 39, female = 39, age 51 ± 12 years) were included. Average number of session was 10 ± 6 (1–30). In our patient population, theophylline administration was the only parameter, which significantly prolonged seizure duration, whereas S-ketamine, remifentanil, thiopental, age, sex, session or energy level had no significant effect. Conclusion Theophylline can be a useful adjunct for patients with inadequate seizure duration. If there is a concomitant beneficial effect on patients’ outcome needs to be investigated in further studies.http://link.springer.com/article/10.1186/s12871-017-0412-5ECTSeizure durationTheophyllineRemifentanil(S-)ketamineBarbiturate |
| spellingShingle | Alexander Tzabazis Michaela E. Wiernik Jan Wielopolski Wolfgang Sperling Harald Ihmsen Hubert J. Schmitt Tino Münster Intravenous theophylline is the most effective intervention to prolong EEG seizure duration in patients undergoing electroconvulsive therapy BMC Anesthesiology ECT Seizure duration Theophylline Remifentanil (S-)ketamine Barbiturate |
| title | Intravenous theophylline is the most effective intervention to prolong EEG seizure duration in patients undergoing electroconvulsive therapy |
| title_full | Intravenous theophylline is the most effective intervention to prolong EEG seizure duration in patients undergoing electroconvulsive therapy |
| title_fullStr | Intravenous theophylline is the most effective intervention to prolong EEG seizure duration in patients undergoing electroconvulsive therapy |
| title_full_unstemmed | Intravenous theophylline is the most effective intervention to prolong EEG seizure duration in patients undergoing electroconvulsive therapy |
| title_short | Intravenous theophylline is the most effective intervention to prolong EEG seizure duration in patients undergoing electroconvulsive therapy |
| title_sort | intravenous theophylline is the most effective intervention to prolong eeg seizure duration in patients undergoing electroconvulsive therapy |
| topic | ECT Seizure duration Theophylline Remifentanil (S-)ketamine Barbiturate |
| url | http://link.springer.com/article/10.1186/s12871-017-0412-5 |
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