NHS-POx-loaded patch versus fibrin sealant patch in a porcine robotic liver bleeding model
Abstract Background The management of bleeding is paramount to any surgical procedure. With the increased use of less invasive laparoscopic and robotic methods, achieving hemostasis can be challenging since the surgeons cannot manually apply hemostatic agents directly onto bleeding tissue. In this s...
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BMC
2023-08-01
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Series: | BMC Surgery |
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Online Access: | https://doi.org/10.1186/s12893-023-02159-4 |
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author | Mathieu D’Hondt Edwin A. Roozen Frederiek Nuytens Johan Bender Alexandre Mottrie Kevin Bauwens Stuart J. Head |
author_facet | Mathieu D’Hondt Edwin A. Roozen Frederiek Nuytens Johan Bender Alexandre Mottrie Kevin Bauwens Stuart J. Head |
author_sort | Mathieu D’Hondt |
collection | DOAJ |
description | Abstract Background The management of bleeding is paramount to any surgical procedure. With the increased use of less invasive laparoscopic and robotic methods, achieving hemostasis can be challenging since the surgeons cannot manually apply hemostatic agents directly onto bleeding tissue. In this study, we assessed the use of a pliable hemostatic sealant patch comprising fibrous gelatin carrier impregnated with poly(2-oxazoline) (NHS-POx) for hemostasis in robotic liver resection in a porcine bleeding model. Methods The NHS-POx-loaded patch (GATT-Patch), was first evaluated in a Feasibility Study to treat surgical bleeding in 10 lesions, followed by a Comparative Study in which the NHS-POx patch was compared to a standard-of-care fibrin sealant patch (TachoSil), in 36 lesions (superficial, resection, or deep injuries mimicking metastasectomies). For each lesion type, the NHS-POx and fibrin sealant patches were used in an alternating fashion with 18 lesions treated with NHS-POx and 18 with the fibrin patch. Animal preparation and surgical procedures were consistent across studies. The primary outcome was time to hemostasis (TTH) within 3 min for the Feasibility Study and within 5 min for the Comparative Study. Results In the Feasibility Study, 8 of the 10 NHS-POx-treated lesions achieved hemostasis at 30 s and 3 min. In the Comparative Study, all 18 NHS-POx patch-treated lesions and 9 of the 18 fibrin sealant patch-treated lesions achieved hemostasis at 5 min. Median TTH with NHS-POx vs fibrin sealant patch was 30 vs 300 s (P < 0.001). Conclusions In this animal study, hemostasis during robotic liver surgery was achieved faster and more often with the NHS-POx loaded vs fibrin sealant patch. |
first_indexed | 2024-03-10T22:23:38Z |
format | Article |
id | doaj.art-dd85d8b50b6e437281620350eab2f04c |
institution | Directory Open Access Journal |
issn | 1471-2482 |
language | English |
last_indexed | 2024-03-10T22:23:38Z |
publishDate | 2023-08-01 |
publisher | BMC |
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series | BMC Surgery |
spelling | doaj.art-dd85d8b50b6e437281620350eab2f04c2023-11-19T12:12:56ZengBMCBMC Surgery1471-24822023-08-0123111010.1186/s12893-023-02159-4NHS-POx-loaded patch versus fibrin sealant patch in a porcine robotic liver bleeding modelMathieu D’Hondt0Edwin A. Roozen1Frederiek Nuytens2Johan Bender3Alexandre Mottrie4Kevin Bauwens5Stuart J. Head6Department of Digestive and Hepatobiliary/Pancreatic Surgery, AZ Groeninge HospitalGATT TechnologiesDepartment of Digestive and Hepatobiliary/Pancreatic Surgery, AZ Groeninge HospitalGATT TechnologiesORSI AcademyORSI AcademyGATT TechnologiesAbstract Background The management of bleeding is paramount to any surgical procedure. With the increased use of less invasive laparoscopic and robotic methods, achieving hemostasis can be challenging since the surgeons cannot manually apply hemostatic agents directly onto bleeding tissue. In this study, we assessed the use of a pliable hemostatic sealant patch comprising fibrous gelatin carrier impregnated with poly(2-oxazoline) (NHS-POx) for hemostasis in robotic liver resection in a porcine bleeding model. Methods The NHS-POx-loaded patch (GATT-Patch), was first evaluated in a Feasibility Study to treat surgical bleeding in 10 lesions, followed by a Comparative Study in which the NHS-POx patch was compared to a standard-of-care fibrin sealant patch (TachoSil), in 36 lesions (superficial, resection, or deep injuries mimicking metastasectomies). For each lesion type, the NHS-POx and fibrin sealant patches were used in an alternating fashion with 18 lesions treated with NHS-POx and 18 with the fibrin patch. Animal preparation and surgical procedures were consistent across studies. The primary outcome was time to hemostasis (TTH) within 3 min for the Feasibility Study and within 5 min for the Comparative Study. Results In the Feasibility Study, 8 of the 10 NHS-POx-treated lesions achieved hemostasis at 30 s and 3 min. In the Comparative Study, all 18 NHS-POx patch-treated lesions and 9 of the 18 fibrin sealant patch-treated lesions achieved hemostasis at 5 min. Median TTH with NHS-POx vs fibrin sealant patch was 30 vs 300 s (P < 0.001). Conclusions In this animal study, hemostasis during robotic liver surgery was achieved faster and more often with the NHS-POx loaded vs fibrin sealant patch.https://doi.org/10.1186/s12893-023-02159-4BleedingHemostasisNHS-POx patchGATT-PatchTachoSilFibrin sealant patch |
spellingShingle | Mathieu D’Hondt Edwin A. Roozen Frederiek Nuytens Johan Bender Alexandre Mottrie Kevin Bauwens Stuart J. Head NHS-POx-loaded patch versus fibrin sealant patch in a porcine robotic liver bleeding model BMC Surgery Bleeding Hemostasis NHS-POx patch GATT-Patch TachoSil Fibrin sealant patch |
title | NHS-POx-loaded patch versus fibrin sealant patch in a porcine robotic liver bleeding model |
title_full | NHS-POx-loaded patch versus fibrin sealant patch in a porcine robotic liver bleeding model |
title_fullStr | NHS-POx-loaded patch versus fibrin sealant patch in a porcine robotic liver bleeding model |
title_full_unstemmed | NHS-POx-loaded patch versus fibrin sealant patch in a porcine robotic liver bleeding model |
title_short | NHS-POx-loaded patch versus fibrin sealant patch in a porcine robotic liver bleeding model |
title_sort | nhs pox loaded patch versus fibrin sealant patch in a porcine robotic liver bleeding model |
topic | Bleeding Hemostasis NHS-POx patch GATT-Patch TachoSil Fibrin sealant patch |
url | https://doi.org/10.1186/s12893-023-02159-4 |
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