Polysaccharides as Stabilizers for Polymeric Microcarriers Fabrication
Biodegradable polymeric microparticles are widely used in drug delivery systems with prolonged-release profiles and/or cell microcarriers. Their fabrication via the oil/water emulsion solvent evaporation technique has normally required emulsifiers in the aqueous phase. The present work aims to evalu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/13/18/3045 |
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| author | Tatiana S. Demina Liubov A. Kilyashova Tatiana N. Popyrina Eugenia A. Svidchenko Sankarprasad Bhuniya Tatiana A. Akopova Christian Grandfils |
| author_facet | Tatiana S. Demina Liubov A. Kilyashova Tatiana N. Popyrina Eugenia A. Svidchenko Sankarprasad Bhuniya Tatiana A. Akopova Christian Grandfils |
| author_sort | Tatiana S. Demina |
| collection | DOAJ |
| description | Biodegradable polymeric microparticles are widely used in drug delivery systems with prolonged-release profiles and/or cell microcarriers. Their fabrication via the oil/water emulsion solvent evaporation technique has normally required emulsifiers in the aqueous phase. The present work aims to evaluate the effectiveness of various polysaccharides, such as chitosan, hyaluronic acid, cellulose, arabinogalactan, guar and their derivatives, as an alternative to synthetic surfactants for polylactide microparticle stabilization during their fabrication. Targeted modification of the biopolymer’s chemical structure was also tested as a tool to enhance polysaccharides’ emulsifying ability. The transformation of biomacromolecules into a form of nanoparticle via bottom-up or top-down methods and their subsequent application for microparticle fabrication via the Pickering emulsion solvent evaporation technique was useful as a one-step approach towards the preparation of core/shell microparticles. The effect of polysaccharides’ chemical structure and the form of their application on the polylactide microparticles’ total yield, size distribution and morphology was evaluated. The application of polysaccharides has great potential in terms of the development of green chemistry and the biocompatibility of the formed microparticles, which is especially important in biomedicine application. |
| first_indexed | 2024-03-10T07:17:47Z |
| format | Article |
| id | doaj.art-dd86adadf52343d08e7329c15864e9b5 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T07:17:47Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-dd86adadf52343d08e7329c15864e9b52023-11-22T14:55:12ZengMDPI AGPolymers2073-43602021-09-011318304510.3390/polym13183045Polysaccharides as Stabilizers for Polymeric Microcarriers FabricationTatiana S. Demina0Liubov A. Kilyashova1Tatiana N. Popyrina2Eugenia A. Svidchenko3Sankarprasad Bhuniya4Tatiana A. Akopova5Christian Grandfils6Enikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences, 70 Profsouznaya Str., 117393 Moscow, RussiaMoscow Aviation Institute, National Research University, Orshanskaya Str. 3, 121552 Moscow, RussiaEnikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences, 70 Profsouznaya Str., 117393 Moscow, RussiaEnikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences, 70 Profsouznaya Str., 117393 Moscow, RussiaCentre Interdisciplinary Sciences of the JIS Institute of Advanced Studies and Research (JISIASR), JIS University, Arch Waterfront, GP Block, Sector V Bidhannagar, Kolkata 700091, West Bengal, IndiaEnikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences, 70 Profsouznaya Str., 117393 Moscow, RussiaInterfaculty Research Centre on Biomaterials (CEIB), Chemistry Institute, University of Liège, B6C, 11 Allée du 6 août, Sart-Tilman, B-4000 Liege, BelgiumBiodegradable polymeric microparticles are widely used in drug delivery systems with prolonged-release profiles and/or cell microcarriers. Their fabrication via the oil/water emulsion solvent evaporation technique has normally required emulsifiers in the aqueous phase. The present work aims to evaluate the effectiveness of various polysaccharides, such as chitosan, hyaluronic acid, cellulose, arabinogalactan, guar and their derivatives, as an alternative to synthetic surfactants for polylactide microparticle stabilization during their fabrication. Targeted modification of the biopolymer’s chemical structure was also tested as a tool to enhance polysaccharides’ emulsifying ability. The transformation of biomacromolecules into a form of nanoparticle via bottom-up or top-down methods and their subsequent application for microparticle fabrication via the Pickering emulsion solvent evaporation technique was useful as a one-step approach towards the preparation of core/shell microparticles. The effect of polysaccharides’ chemical structure and the form of their application on the polylactide microparticles’ total yield, size distribution and morphology was evaluated. The application of polysaccharides has great potential in terms of the development of green chemistry and the biocompatibility of the formed microparticles, which is especially important in biomedicine application.https://www.mdpi.com/2073-4360/13/18/3045microcarrierspolysaccharidesoil/water emulsionsinterfacePickering emulsionsstabilization |
| spellingShingle | Tatiana S. Demina Liubov A. Kilyashova Tatiana N. Popyrina Eugenia A. Svidchenko Sankarprasad Bhuniya Tatiana A. Akopova Christian Grandfils Polysaccharides as Stabilizers for Polymeric Microcarriers Fabrication Polymers microcarriers polysaccharides oil/water emulsions interface Pickering emulsions stabilization |
| title | Polysaccharides as Stabilizers for Polymeric Microcarriers Fabrication |
| title_full | Polysaccharides as Stabilizers for Polymeric Microcarriers Fabrication |
| title_fullStr | Polysaccharides as Stabilizers for Polymeric Microcarriers Fabrication |
| title_full_unstemmed | Polysaccharides as Stabilizers for Polymeric Microcarriers Fabrication |
| title_short | Polysaccharides as Stabilizers for Polymeric Microcarriers Fabrication |
| title_sort | polysaccharides as stabilizers for polymeric microcarriers fabrication |
| topic | microcarriers polysaccharides oil/water emulsions interface Pickering emulsions stabilization |
| url | https://www.mdpi.com/2073-4360/13/18/3045 |
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