Clinical and Computed Tomography Characteristics of Solitary Pulmonary Nodules Caused by Fungi: A Comparative Study
Jin Jiang,1,* Zhuo-ma Lv,1,2,* Fa-jin Lv,1 Bin-jie Fu,1 Zhang-rui Liang,1 Zhi-gang Chu1 1Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Department of Radiology, The Second People’s Hospital of Yubei Dist...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-10-01
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| Series: | Infection and Drug Resistance |
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| Online Access: | https://www.dovepress.com/clinical-and-computed-tomography-characteristics-of-solitary-pulmonary-peer-reviewed-fulltext-article-IDR |
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| author | Jiang J Lv ZM Lv FJ Fu BJ Liang ZR Chu ZG |
| author_facet | Jiang J Lv ZM Lv FJ Fu BJ Liang ZR Chu ZG |
| author_sort | Jiang J |
| collection | DOAJ |
| description | Jin Jiang,1,* Zhuo-ma Lv,1,2,* Fa-jin Lv,1 Bin-jie Fu,1 Zhang-rui Liang,1 Zhi-gang Chu1 1Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Department of Radiology, The Second People’s Hospital of Yubei District, Chongqing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhi-gang Chu, Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, 1# Youyi Road, Yuanjiagang, Yuzhong district, Chongqing, 400016, People’s Republic of China, Tel +86 18723032809, Fax +86 23 68811487, Email chuzg0815@163.comPurpose: To clarify the clinical and computed tomography (CT) indicators in distinguishing pulmonary nodules caused by fungal infection from lung cancers.Methods: From January 2013 to April 2022, 68 patients with solitary fungal nodules (64 were solid and 4 were mixed ground-glass nodules) and 140 cases with solid cancerous nodules with similar size were enrolled. Their clinical characteristics and CT manifestations of the solid nodules were summarized and compared, respectively.Results: Compared with patients with lung cancers, cases were younger (51.2 ± 11.5 vs 61.3 ± 10.2 years) and non-smokers (72.1% vs 57.9%) and immunocompromised (44.1% vs 17.9%) individuals were more common in patients with fungal nodules (each P < 0.05). The air crescent sign (ACS) (34.4% vs 0%), halo sign (HS) (23.4% vs 4.3%), and satellite lesions (45.3% vs 2.9%) were more frequently detected in fungal nodules than in cancerous ones (each P < 0.05). Air bronchogram similarly occurred in fungal and cancerous nodules, whereas the natural ones were more common in the former (100% vs 16.7%, P = 0.000). However, the fungal nodules had a lower enhancement degree (29.0 ± 19.2 HU vs 40.3 ± 28.3 HU, P = 0.038) and frequency of hilar and/or mediastinal lymph node enlargement (2.9% vs 14.3%, P = 0.013) compared with the cancerous nodules.Conclusion: In the younger, non-smoking and immunocompromised patients, a solitary pulmonary solid nodule with ACS, HS, satellite lesions and/or natural air bronchogram but without significant enhancement, fungal infection is a probable diagnosis.Keywords: tomography, X-ray computed, pulmonary nodules, fungal infection |
| first_indexed | 2024-04-11T09:24:04Z |
| format | Article |
| id | doaj.art-dd86d4d0bdc5468e82ff110a69403e8e |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-04-11T09:24:04Z |
| publishDate | 2022-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-dd86d4d0bdc5468e82ff110a69403e8e2022-12-22T04:32:06ZengDove Medical PressInfection and Drug Resistance1178-69732022-10-01Volume 156019602879053Clinical and Computed Tomography Characteristics of Solitary Pulmonary Nodules Caused by Fungi: A Comparative StudyJiang JLv ZMLv FJFu BJLiang ZRChu ZGJin Jiang,1,* Zhuo-ma Lv,1,2,* Fa-jin Lv,1 Bin-jie Fu,1 Zhang-rui Liang,1 Zhi-gang Chu1 1Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Department of Radiology, The Second People’s Hospital of Yubei District, Chongqing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhi-gang Chu, Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, 1# Youyi Road, Yuanjiagang, Yuzhong district, Chongqing, 400016, People’s Republic of China, Tel +86 18723032809, Fax +86 23 68811487, Email chuzg0815@163.comPurpose: To clarify the clinical and computed tomography (CT) indicators in distinguishing pulmonary nodules caused by fungal infection from lung cancers.Methods: From January 2013 to April 2022, 68 patients with solitary fungal nodules (64 were solid and 4 were mixed ground-glass nodules) and 140 cases with solid cancerous nodules with similar size were enrolled. Their clinical characteristics and CT manifestations of the solid nodules were summarized and compared, respectively.Results: Compared with patients with lung cancers, cases were younger (51.2 ± 11.5 vs 61.3 ± 10.2 years) and non-smokers (72.1% vs 57.9%) and immunocompromised (44.1% vs 17.9%) individuals were more common in patients with fungal nodules (each P < 0.05). The air crescent sign (ACS) (34.4% vs 0%), halo sign (HS) (23.4% vs 4.3%), and satellite lesions (45.3% vs 2.9%) were more frequently detected in fungal nodules than in cancerous ones (each P < 0.05). Air bronchogram similarly occurred in fungal and cancerous nodules, whereas the natural ones were more common in the former (100% vs 16.7%, P = 0.000). However, the fungal nodules had a lower enhancement degree (29.0 ± 19.2 HU vs 40.3 ± 28.3 HU, P = 0.038) and frequency of hilar and/or mediastinal lymph node enlargement (2.9% vs 14.3%, P = 0.013) compared with the cancerous nodules.Conclusion: In the younger, non-smoking and immunocompromised patients, a solitary pulmonary solid nodule with ACS, HS, satellite lesions and/or natural air bronchogram but without significant enhancement, fungal infection is a probable diagnosis.Keywords: tomography, X-ray computed, pulmonary nodules, fungal infectionhttps://www.dovepress.com/clinical-and-computed-tomography-characteristics-of-solitary-pulmonary-peer-reviewed-fulltext-article-IDRtomographyx-ray computedpulmonary nodulesfungal infection |
| spellingShingle | Jiang J Lv ZM Lv FJ Fu BJ Liang ZR Chu ZG Clinical and Computed Tomography Characteristics of Solitary Pulmonary Nodules Caused by Fungi: A Comparative Study Infection and Drug Resistance tomography x-ray computed pulmonary nodules fungal infection |
| title | Clinical and Computed Tomography Characteristics of Solitary Pulmonary Nodules Caused by Fungi: A Comparative Study |
| title_full | Clinical and Computed Tomography Characteristics of Solitary Pulmonary Nodules Caused by Fungi: A Comparative Study |
| title_fullStr | Clinical and Computed Tomography Characteristics of Solitary Pulmonary Nodules Caused by Fungi: A Comparative Study |
| title_full_unstemmed | Clinical and Computed Tomography Characteristics of Solitary Pulmonary Nodules Caused by Fungi: A Comparative Study |
| title_short | Clinical and Computed Tomography Characteristics of Solitary Pulmonary Nodules Caused by Fungi: A Comparative Study |
| title_sort | clinical and computed tomography characteristics of solitary pulmonary nodules caused by fungi a comparative study |
| topic | tomography x-ray computed pulmonary nodules fungal infection |
| url | https://www.dovepress.com/clinical-and-computed-tomography-characteristics-of-solitary-pulmonary-peer-reviewed-fulltext-article-IDR |
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