Current insights and future perspectives of ultraviolet radiation (UV) exposure: Friends and foes to the skin and beyond the skin
Ultraviolet (UV) radiation is ubiquitous in the environment, which has been classified as an established human carcinogen. As the largest and outermost organ of the body, direct exposure of skin to sunlight or UV radiation can result in sunburn, inflammation, photo-immunosuppression, photoaging and...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-03-01
|
| Series: | Environment International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412024001211 |
| _version_ | 1797248445285662720 |
|---|---|
| author | Xiaoyou Tang Tingyi Yang Daojiang Yu Hai Xiong Shuyu Zhang |
| author_facet | Xiaoyou Tang Tingyi Yang Daojiang Yu Hai Xiong Shuyu Zhang |
| author_sort | Xiaoyou Tang |
| collection | DOAJ |
| description | Ultraviolet (UV) radiation is ubiquitous in the environment, which has been classified as an established human carcinogen. As the largest and outermost organ of the body, direct exposure of skin to sunlight or UV radiation can result in sunburn, inflammation, photo-immunosuppression, photoaging and even skin cancers. To date, there are tactics to protect the skin by preventing UV radiation and reducing the amount of UV radiation to the skin. Nevertheless, deciphering the essential regulatory mechanisms may pave the way for therapeutic interventions against UV-induced skin disorders. Additionally, UV light is considered beneficial for specific skin-related conditions in medical UV therapy. Recent evidence indicates that the biological effects of UV exposure extend beyond the skin and include the treatment of inflammatory diseases, solid tumors and certain abnormal behaviors. This review mainly focuses on the effects of UV on the skin. Moreover, novel findings of the biological effects of UV in other organs and systems are also summarized. Nevertheless, the mechanisms through which UV affects the human organism remain to be fully elucidated to achieve a more comprehensive understanding of its biological effects. |
| first_indexed | 2024-03-07T19:10:47Z |
| format | Article |
| id | doaj.art-dd8a543cf95f40da977cb48111e9820e |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-04-24T20:14:42Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-dd8a543cf95f40da977cb48111e9820e2024-03-23T06:22:16ZengElsevierEnvironment International0160-41202024-03-01185108535Current insights and future perspectives of ultraviolet radiation (UV) exposure: Friends and foes to the skin and beyond the skinXiaoyou Tang0Tingyi Yang1Daojiang Yu2Hai Xiong3Shuyu Zhang4Medical College of Tibet University, Lasa 850000, China; Laboratory of Radiation Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, ChinaLaboratory of Radiation Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, ChinaLaboratory of Radiation Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China; The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu 610051, ChinaMedical College of Tibet University, Lasa 850000, China; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China; Corresponding authors at: Medical College of Tibet University, Lasa 850000, China.Medical College of Tibet University, Lasa 850000, China; Laboratory of Radiation Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China; The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu 610051, China; NHC Key Laboratory of Nuclear Technology Medical Transformation (Mianyang Central Hospital), Mianyang 621099, China; Corresponding authors at: Medical College of Tibet University, Lasa 850000, China.Ultraviolet (UV) radiation is ubiquitous in the environment, which has been classified as an established human carcinogen. As the largest and outermost organ of the body, direct exposure of skin to sunlight or UV radiation can result in sunburn, inflammation, photo-immunosuppression, photoaging and even skin cancers. To date, there are tactics to protect the skin by preventing UV radiation and reducing the amount of UV radiation to the skin. Nevertheless, deciphering the essential regulatory mechanisms may pave the way for therapeutic interventions against UV-induced skin disorders. Additionally, UV light is considered beneficial for specific skin-related conditions in medical UV therapy. Recent evidence indicates that the biological effects of UV exposure extend beyond the skin and include the treatment of inflammatory diseases, solid tumors and certain abnormal behaviors. This review mainly focuses on the effects of UV on the skin. Moreover, novel findings of the biological effects of UV in other organs and systems are also summarized. Nevertheless, the mechanisms through which UV affects the human organism remain to be fully elucidated to achieve a more comprehensive understanding of its biological effects.http://www.sciencedirect.com/science/article/pii/S0160412024001211ultraviolet radiation (UV)SkinDamagePrevention |
| spellingShingle | Xiaoyou Tang Tingyi Yang Daojiang Yu Hai Xiong Shuyu Zhang Current insights and future perspectives of ultraviolet radiation (UV) exposure: Friends and foes to the skin and beyond the skin Environment International ultraviolet radiation (UV) Skin Damage Prevention |
| title | Current insights and future perspectives of ultraviolet radiation (UV) exposure: Friends and foes to the skin and beyond the skin |
| title_full | Current insights and future perspectives of ultraviolet radiation (UV) exposure: Friends and foes to the skin and beyond the skin |
| title_fullStr | Current insights and future perspectives of ultraviolet radiation (UV) exposure: Friends and foes to the skin and beyond the skin |
| title_full_unstemmed | Current insights and future perspectives of ultraviolet radiation (UV) exposure: Friends and foes to the skin and beyond the skin |
| title_short | Current insights and future perspectives of ultraviolet radiation (UV) exposure: Friends and foes to the skin and beyond the skin |
| title_sort | current insights and future perspectives of ultraviolet radiation uv exposure friends and foes to the skin and beyond the skin |
| topic | ultraviolet radiation (UV) Skin Damage Prevention |
| url | http://www.sciencedirect.com/science/article/pii/S0160412024001211 |
| work_keys_str_mv | AT xiaoyoutang currentinsightsandfutureperspectivesofultravioletradiationuvexposurefriendsandfoestotheskinandbeyondtheskin AT tingyiyang currentinsightsandfutureperspectivesofultravioletradiationuvexposurefriendsandfoestotheskinandbeyondtheskin AT daojiangyu currentinsightsandfutureperspectivesofultravioletradiationuvexposurefriendsandfoestotheskinandbeyondtheskin AT haixiong currentinsightsandfutureperspectivesofultravioletradiationuvexposurefriendsandfoestotheskinandbeyondtheskin AT shuyuzhang currentinsightsandfutureperspectivesofultravioletradiationuvexposurefriendsandfoestotheskinandbeyondtheskin |