B‐cell receptors of EBV‐negative Burkitt lymphoma bind modified isoforms of autoantigens

B‐cell receptors of EBV‐negative Burkitt lymphoma bind modified isoforms of autoantigens

Abstract Burkitt lymphoma (BL) represents the most aggressive B‐cell‐lymphoma. Beside the hallmark of IG‐MYC‐translocation, surface B‐cell receptor (BCR) is expressed, and mutations in the BCR pathway are frequent. Coincidental infections in endemic BL, and specific extra‐nodal sites suggest antigen...

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Bibliographic Details
Main Authors: Theresa Bock, Moritz Bewarder, Onur Cetin, Natalie Fadle, Evi Regitz, Eva C. Schwarz, Jana Held, Sophie Roth, Stefan Lohse, Thorsten Pfuhl, Rabea Wagener, Sigrun Smola, Sören L. Becker, Rainer Maria Bohle, Lorenz Trümper, Reiner Siebert, Martin‐Leo Hansmann, Michael Pfreundschuh, Hans G. Drexler, Markus Hoth, Boris Kubuschok, Klaus Roemer, Klaus‐Dieter Preuss, Sylvia Hartmann, Lorenz Thurner
Format: Article
Language:English
Published: Wiley 2022-08-01
Series:eJHaem
Subjects:
atypical post‐translationally modified isoforms
autoantigens
BCR
Burkitt lymphoma
immunotoxins
neoantigens
Online Access:https://doi.org/10.1002/jha2.475

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