Incidental Prostate Cancer in Patients Treated for Benign Prostatic Hyperplasia: Analysis from a Contemporary National Dataset
(1) Background: Prostate Cancer (PCa) may be incidentally diagnosed during the microscopic evaluation of resected tissue from BPH surgeries, characterizing the clinical condition known as incidental PCa (iPCa). This study aims to assess the prevalence of iPCa following BPH surgery to evaluate the as...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/14/7/677 |
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| author | Eugenio Bologna Leslie Claire Licari Antonio Franco Francesco Ditonno Celeste Manfredi Cosimo De Nunzio Alessandro Antonelli Marco De Sio Costantino Leonardo Giuseppe Simone Edward E. Cherullo Riccardo Autorino |
| author_facet | Eugenio Bologna Leslie Claire Licari Antonio Franco Francesco Ditonno Celeste Manfredi Cosimo De Nunzio Alessandro Antonelli Marco De Sio Costantino Leonardo Giuseppe Simone Edward E. Cherullo Riccardo Autorino |
| author_sort | Eugenio Bologna |
| collection | DOAJ |
| description | (1) Background: Prostate Cancer (PCa) may be incidentally diagnosed during the microscopic evaluation of resected tissue from BPH surgeries, characterizing the clinical condition known as incidental PCa (iPCa). This study aims to assess the prevalence of iPCa following BPH surgery to evaluate the associated surgical procedures and to scrutinize preoperative and postoperative management. (2) Methods: A retrospective analysis was conducted using the PearlDiver™ Mariner database, containing patient records compiled between 2011 and 2021. International Classification of Diseases (ICD) and Current Procedural Terminology (CPT) codes were employed to identify the population and outcomes. Our primary objective was to assess the prevalence of iPCa, categorized by the type of procedures, and to evaluate the subsequent treatment strategies. The secondary aim was to assess the impact of prostate biopsy (PB) and prostate MRI on iPCa detection. (3) Results: The overall cohort, accounting for 231,626 patients who underwent BPH surgery, exhibited a 2.2% prevalence rate of iPCa. The highest rate was observed for TURP (2.32%), while the lowest was recorded for RASP (1.18%). Preoperative MRI and PB demonstrated opposing trends over the years. Of the 5090 patients identified with iPCa, nearly 68% did not receive active treatment. The most common treatments were RT and ADT; 34.6% underwent RT, 31.75% received ADT, and 21.75% were treated with RT+ADT. RP was administered to approximately 9% of patients undergoing endoscopic procedures. Multivariate logistic regression analysis revealed age and openSP as additional risk factors for iPCa. Conversely, PB and MRI before surgery were linked to a decreased risk. (4) Conclusions: The contemporary prevalence of iPCa after BPH surgery is <3%. The increase in the use of prostate MRI mirrors a decline in the PB biopsy prior to BPH surgery but without resulting in an increased detection rate of iPCa. In contemporary routine clinical practice, iPCa is mostly managed in a different way when compared to biopsy-detected PCa. |
| first_indexed | 2024-04-24T10:48:20Z |
| format | Article |
| id | doaj.art-dd8cdb7b51f84fb7936030ca9d7d4812 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-04-24T10:48:20Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-dd8cdb7b51f84fb7936030ca9d7d48122024-04-12T13:16:40ZengMDPI AGDiagnostics2075-44182024-03-0114767710.3390/diagnostics14070677Incidental Prostate Cancer in Patients Treated for Benign Prostatic Hyperplasia: Analysis from a Contemporary National DatasetEugenio Bologna0Leslie Claire Licari1Antonio Franco2Francesco Ditonno3Celeste Manfredi4Cosimo De Nunzio5Alessandro Antonelli6Marco De Sio7Costantino Leonardo8Giuseppe Simone9Edward E. Cherullo10Riccardo Autorino11Department of Maternal-Child and Urological Sciences, Sapienza University Rome, Policlinico Umberto I Hospital, 00161 Rome, ItalyDepartment of Maternal-Child and Urological Sciences, Sapienza University Rome, Policlinico Umberto I Hospital, 00161 Rome, ItalyDepartment of Urology, Rush University, Chicago, IL 60612, USADepartment of Urology, Rush University, Chicago, IL 60612, USADepartment of Urology, Rush University, Chicago, IL 60612, USADepartment of Urology, Sant’Andrea Hospital, Sapienza University, 00189 Rome, ItalyDepartment of Urology, Azienda Ospedaliera Universitaria Integrata Verona, University of Verona, 37129 Verona, ItalyUnit of Urology, Department of Woman, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80131 Naples, ItalyDepartment of Urology, “Regina Elena” National Cancer Institute, 00144 Rome, ItalyDepartment of Urology, “Regina Elena” National Cancer Institute, 00144 Rome, ItalyDepartment of Urology, Rush University, Chicago, IL 60612, USADepartment of Urology, Rush University, Chicago, IL 60612, USA(1) Background: Prostate Cancer (PCa) may be incidentally diagnosed during the microscopic evaluation of resected tissue from BPH surgeries, characterizing the clinical condition known as incidental PCa (iPCa). This study aims to assess the prevalence of iPCa following BPH surgery to evaluate the associated surgical procedures and to scrutinize preoperative and postoperative management. (2) Methods: A retrospective analysis was conducted using the PearlDiver™ Mariner database, containing patient records compiled between 2011 and 2021. International Classification of Diseases (ICD) and Current Procedural Terminology (CPT) codes were employed to identify the population and outcomes. Our primary objective was to assess the prevalence of iPCa, categorized by the type of procedures, and to evaluate the subsequent treatment strategies. The secondary aim was to assess the impact of prostate biopsy (PB) and prostate MRI on iPCa detection. (3) Results: The overall cohort, accounting for 231,626 patients who underwent BPH surgery, exhibited a 2.2% prevalence rate of iPCa. The highest rate was observed for TURP (2.32%), while the lowest was recorded for RASP (1.18%). Preoperative MRI and PB demonstrated opposing trends over the years. Of the 5090 patients identified with iPCa, nearly 68% did not receive active treatment. The most common treatments were RT and ADT; 34.6% underwent RT, 31.75% received ADT, and 21.75% were treated with RT+ADT. RP was administered to approximately 9% of patients undergoing endoscopic procedures. Multivariate logistic regression analysis revealed age and openSP as additional risk factors for iPCa. Conversely, PB and MRI before surgery were linked to a decreased risk. (4) Conclusions: The contemporary prevalence of iPCa after BPH surgery is <3%. The increase in the use of prostate MRI mirrors a decline in the PB biopsy prior to BPH surgery but without resulting in an increased detection rate of iPCa. In contemporary routine clinical practice, iPCa is mostly managed in a different way when compared to biopsy-detected PCa.https://www.mdpi.com/2075-4418/14/7/677BPHincidentalMRIprostate biopsyprostate cancer |
| spellingShingle | Eugenio Bologna Leslie Claire Licari Antonio Franco Francesco Ditonno Celeste Manfredi Cosimo De Nunzio Alessandro Antonelli Marco De Sio Costantino Leonardo Giuseppe Simone Edward E. Cherullo Riccardo Autorino Incidental Prostate Cancer in Patients Treated for Benign Prostatic Hyperplasia: Analysis from a Contemporary National Dataset Diagnostics BPH incidental MRI prostate biopsy prostate cancer |
| title | Incidental Prostate Cancer in Patients Treated for Benign Prostatic Hyperplasia: Analysis from a Contemporary National Dataset |
| title_full | Incidental Prostate Cancer in Patients Treated for Benign Prostatic Hyperplasia: Analysis from a Contemporary National Dataset |
| title_fullStr | Incidental Prostate Cancer in Patients Treated for Benign Prostatic Hyperplasia: Analysis from a Contemporary National Dataset |
| title_full_unstemmed | Incidental Prostate Cancer in Patients Treated for Benign Prostatic Hyperplasia: Analysis from a Contemporary National Dataset |
| title_short | Incidental Prostate Cancer in Patients Treated for Benign Prostatic Hyperplasia: Analysis from a Contemporary National Dataset |
| title_sort | incidental prostate cancer in patients treated for benign prostatic hyperplasia analysis from a contemporary national dataset |
| topic | BPH incidental MRI prostate biopsy prostate cancer |
| url | https://www.mdpi.com/2075-4418/14/7/677 |
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