Dietary intake effects on severity of cancer treatment‐induced mucositis: A cross‐sectional study
Abstract Background and Aims Oral mucositis is one of the most serious complications due to chemotherapy and radiotherapy in head and neck cancer treatment. Oral mucositis causes a wide range of clinical signs and symptoms, such as ulcers, pain, and dysphagia. Additionally, because of speech limitat...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-11-01
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| Series: | Health Science Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/hsr2.1706 |
| _version_ | 1797448763904622592 |
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| author | Soheila Manifar Arghavan Tonkaboni Aysan Sobhanifar Kimia HafeziMotlagh Sama Bitarafan Mina Mazani Paolo Bossi |
| author_facet | Soheila Manifar Arghavan Tonkaboni Aysan Sobhanifar Kimia HafeziMotlagh Sama Bitarafan Mina Mazani Paolo Bossi |
| author_sort | Soheila Manifar |
| collection | DOAJ |
| description | Abstract Background and Aims Oral mucositis is one of the most serious complications due to chemotherapy and radiotherapy in head and neck cancer treatment. Oral mucositis causes a wide range of clinical signs and symptoms, such as ulcers, pain, and dysphagia. Additionally, because of speech limitations, patients' self‐esteem will decrease, ultimately causing reduced quality of life. The primary objective of this study was to investigate the role of diet in the onset and progress of mucositis induced by chemotherapy and radiation therapy in patients with cancers. Methods In this study, 121 patients with a mean age of 51.43 ± 13.08 years were selected randomly and referred to the cancer institute, where they underwent their first phase of chemotherapy. In this step, patients were examined and their severity of oral mucositis was graded according to the World Health Organization criteria. They completed a 3‐day allergen food recall and dietary recommendations were met. After completing the forms, four questionnaires were filled out for each patient, the patient's nutrition was analyzed using the N4 software, and the amount of macro‐ and micronutrients was measured. Results Micronutrients such as aspartic acid, glycine, serine, proline, alanine, arginine, glutamic acid, and vitamin B12 and macronutrients such as rose water, sausage, beverages, coffee, and lamb meat were examined, and a significant difference was observed between groups (grade 1 and 2 mucositis) (p < 0.005). In patients with grade 2 mucositis, a lower level of vitamin B12 was reported (p < 0.005). There is a negative correlation between amounts of macro‐ and micronutrients and grades of oral mucositis. Conclusion It can be concluded that diet plays a considerable role in the severity of oral mucositis caused by cancer treatment. |
| first_indexed | 2024-03-09T14:16:09Z |
| format | Article |
| id | doaj.art-dd8d3b2b8ed34c0b81812a405168a5bb |
| institution | Directory Open Access Journal |
| issn | 2398-8835 |
| language | English |
| last_indexed | 2024-03-09T14:16:09Z |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj.art-dd8d3b2b8ed34c0b81812a405168a5bb2023-11-29T04:12:34ZengWileyHealth Science Reports2398-88352023-11-01611n/an/a10.1002/hsr2.1706Dietary intake effects on severity of cancer treatment‐induced mucositis: A cross‐sectional studySoheila Manifar0Arghavan Tonkaboni1Aysan Sobhanifar2Kimia HafeziMotlagh3Sama Bitarafan4Mina Mazani5Paolo Bossi6Department of Oral Medicine, School of Dentistry Tehran University of Medical Sciences Tehran IranDepartment of Oral Medicine, School of Dentistry Tehran University of Medical Sciences Tehran IranSchool of Dentistry, International Campus Tehran University of Medical Sciences Tehran IranDepartment of Oral Medicine, School of Dentistry Tehran University of Medical Sciences Tehran IranIranian Center of Neurological Research, Neuroscience Institute Tehran University of Medical Sciences Tehran IranSchool of Dentistry, International Campus Tehran University of Medical Sciences Tehran IranMedical Oncology Unit University of Brescia Brescia ItalyAbstract Background and Aims Oral mucositis is one of the most serious complications due to chemotherapy and radiotherapy in head and neck cancer treatment. Oral mucositis causes a wide range of clinical signs and symptoms, such as ulcers, pain, and dysphagia. Additionally, because of speech limitations, patients' self‐esteem will decrease, ultimately causing reduced quality of life. The primary objective of this study was to investigate the role of diet in the onset and progress of mucositis induced by chemotherapy and radiation therapy in patients with cancers. Methods In this study, 121 patients with a mean age of 51.43 ± 13.08 years were selected randomly and referred to the cancer institute, where they underwent their first phase of chemotherapy. In this step, patients were examined and their severity of oral mucositis was graded according to the World Health Organization criteria. They completed a 3‐day allergen food recall and dietary recommendations were met. After completing the forms, four questionnaires were filled out for each patient, the patient's nutrition was analyzed using the N4 software, and the amount of macro‐ and micronutrients was measured. Results Micronutrients such as aspartic acid, glycine, serine, proline, alanine, arginine, glutamic acid, and vitamin B12 and macronutrients such as rose water, sausage, beverages, coffee, and lamb meat were examined, and a significant difference was observed between groups (grade 1 and 2 mucositis) (p < 0.005). In patients with grade 2 mucositis, a lower level of vitamin B12 was reported (p < 0.005). There is a negative correlation between amounts of macro‐ and micronutrients and grades of oral mucositis. Conclusion It can be concluded that diet plays a considerable role in the severity of oral mucositis caused by cancer treatment.https://doi.org/10.1002/hsr2.1706cancerchemotherapydietmucositis |
| spellingShingle | Soheila Manifar Arghavan Tonkaboni Aysan Sobhanifar Kimia HafeziMotlagh Sama Bitarafan Mina Mazani Paolo Bossi Dietary intake effects on severity of cancer treatment‐induced mucositis: A cross‐sectional study Health Science Reports cancer chemotherapy diet mucositis |
| title | Dietary intake effects on severity of cancer treatment‐induced mucositis: A cross‐sectional study |
| title_full | Dietary intake effects on severity of cancer treatment‐induced mucositis: A cross‐sectional study |
| title_fullStr | Dietary intake effects on severity of cancer treatment‐induced mucositis: A cross‐sectional study |
| title_full_unstemmed | Dietary intake effects on severity of cancer treatment‐induced mucositis: A cross‐sectional study |
| title_short | Dietary intake effects on severity of cancer treatment‐induced mucositis: A cross‐sectional study |
| title_sort | dietary intake effects on severity of cancer treatment induced mucositis a cross sectional study |
| topic | cancer chemotherapy diet mucositis |
| url | https://doi.org/10.1002/hsr2.1706 |
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