Prolonged cross-bridge binding triggers muscle dysfunction in a Drosophila model of myosin-based hypertrophic cardiomyopathy

Prolonged cross-bridge binding triggers muscle dysfunction in a Drosophila model of myosin-based hypertrophic cardiomyopathy

K146N is a dominant mutation in human β-cardiac myosin heavy chain, which causes hypertrophic cardiomyopathy. We examined how Drosophila muscle responds to this mutation and integratively analyzed the biochemical, physiological and mechanical foundations of the disease. ATPase assays, actin motility...

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Bibliographic Details
Main Authors: William A Kronert, Kaylyn M Bell, Meera C Viswanathan, Girish C Melkani, Adriana S Trujillo, Alice Huang, Anju Melkani, Anthony Cammarato, Douglas M Swank, Sanford I Bernstein
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-08-01
Series:eLife
Subjects:
muscle fiber
myosin
cardiomyopathy
Online Access:https://elifesciences.org/articles/38064

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