Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology

Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology

Abstract Amyotrophic Lateral Sclerosis (ALS) causes motor neuron degeneration, with 97% of cases exhibiting TDP-43 proteinopathy. Elucidating pathomechanisms has been hampered by disease heterogeneity and difficulties accessing motor neurons. Human induced pluripotent stem cell-derived motor neurons...

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Bibliographic Details
Main Authors:	Oliver J. Ziff, Jacob Neeves, Jamie Mitchell, Giulia Tyzack, Carlos Martinez-Ruiz, Raphaelle Luisier, Anob M. Chakrabarti, Nicholas McGranahan, Kevin Litchfield, Simon J. Boulton, Ammar Al-Chalabi, Gavin Kelly, Jack Humphrey, Rickie Patani
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-023-37630-6

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