Genetic Attenuation of Paraoxonase 1 Activity Induces Proatherogenic Changes in Plasma Proteomes of Mice and Humans

Genetic Attenuation of Paraoxonase 1 Activity Induces Proatherogenic Changes in Plasma Proteomes of Mice and Humans

High-density lipoprotein (HDL), in addition to promoting reverse cholesterol transport, possesses anti-inflammatory, antioxidative, and antithrombotic activities. Paraoxonase 1 (PON1), carried on HDL in the blood, can contribute to these antiatherogenic activities. The <i>PON1</i>-<i&...

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Bibliographic Details
Main Authors: Marta Sikora, Ewa Bretes, Joanna Perła-Kaján, Izabela Lewandowska, Łukasz Marczak, Hieronim Jakubowski
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Antioxidants
Subjects:
<i>PON1</i> genotype
plasma proteomes
lipoproteins
atherosclerosis
humans
mice
Online Access:https://www.mdpi.com/2076-3921/9/12/1198

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