miR-128-3p inhibits apoptosis and inflammation in LPS-induced sepsis by targeting TGFBR2
Sepsis is a systemic inflammatory response that can lead to the dysfunction of many organs. The aberrant expression of miRNAs is associated with the pathogenesis of sepsis. However, the biological functions of miR-128-3p in sepsis remain largely unknown, and its mechanism should be further investiga...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2021-02-01
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| Series: | Open Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/med-2021-0222 |
| _version_ | 1811252843081891840 |
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| author | Yang Peng Han Jianhua Li Shigeng Luo Shaoning Tu Xusheng Ye Zhiqiang |
| author_facet | Yang Peng Han Jianhua Li Shigeng Luo Shaoning Tu Xusheng Ye Zhiqiang |
| author_sort | Yang Peng |
| collection | DOAJ |
| description | Sepsis is a systemic inflammatory response that can lead to the dysfunction of many organs. The aberrant expression of miRNAs is associated with the pathogenesis of sepsis. However, the biological functions of miR-128-3p in sepsis remain largely unknown, and its mechanism should be further investigated. This study aimed to determine the regulatory network of miR-128-3p and TGFBR2 in lipopolysaccharide (LPS)-induced sepsis. |
| first_indexed | 2024-04-12T16:40:46Z |
| format | Article |
| id | doaj.art-dd90e9c345c24a9eb88ad8ac91237f3a |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-04-12T16:40:46Z |
| publishDate | 2021-02-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-dd90e9c345c24a9eb88ad8ac91237f3a2022-12-22T03:24:48ZengDe GruyterOpen Medicine2391-54632021-02-0116127428310.1515/med-2021-0222miR-128-3p inhibits apoptosis and inflammation in LPS-induced sepsis by targeting TGFBR2Yang Peng0Han Jianhua1Li Shigeng2Luo Shaoning3Tu Xusheng4Ye Zhiqiang5Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, 510080, Guangzhou, ChinaDepartment of Emergency, The Third Affiliated Hospital, Sun Yat-sen University, No. 600 Tianhe Road, Tianhe District, 510630, Guangzhou, ChinaDepartment of Emergency, The Third Affiliated Hospital, Sun Yat-sen University, No. 600 Tianhe Road, Tianhe District, 510630, Guangzhou, ChinaDepartment of Emergency, The Third Affiliated Hospital, Sun Yat-sen University, No. 600 Tianhe Road, Tianhe District, 510630, Guangzhou, ChinaDepartment of Emergency, The Third Affiliated Hospital, Sun Yat-sen University, No. 600 Tianhe Road, Tianhe District, 510630, Guangzhou, ChinaDepartment of Emergency, The Third Affiliated Hospital, Sun Yat-sen University, No. 600 Tianhe Road, Tianhe District, 510630, Guangzhou, ChinaSepsis is a systemic inflammatory response that can lead to the dysfunction of many organs. The aberrant expression of miRNAs is associated with the pathogenesis of sepsis. However, the biological functions of miR-128-3p in sepsis remain largely unknown, and its mechanism should be further investigated. This study aimed to determine the regulatory network of miR-128-3p and TGFBR2 in lipopolysaccharide (LPS)-induced sepsis.https://doi.org/10.1515/med-2021-0222sepsismir-128-3ptgfbr2apoptosisinflammation |
| spellingShingle | Yang Peng Han Jianhua Li Shigeng Luo Shaoning Tu Xusheng Ye Zhiqiang miR-128-3p inhibits apoptosis and inflammation in LPS-induced sepsis by targeting TGFBR2 Open Medicine sepsis mir-128-3p tgfbr2 apoptosis inflammation |
| title | miR-128-3p inhibits apoptosis and inflammation in LPS-induced sepsis by targeting TGFBR2 |
| title_full | miR-128-3p inhibits apoptosis and inflammation in LPS-induced sepsis by targeting TGFBR2 |
| title_fullStr | miR-128-3p inhibits apoptosis and inflammation in LPS-induced sepsis by targeting TGFBR2 |
| title_full_unstemmed | miR-128-3p inhibits apoptosis and inflammation in LPS-induced sepsis by targeting TGFBR2 |
| title_short | miR-128-3p inhibits apoptosis and inflammation in LPS-induced sepsis by targeting TGFBR2 |
| title_sort | mir 128 3p inhibits apoptosis and inflammation in lps induced sepsis by targeting tgfbr2 |
| topic | sepsis mir-128-3p tgfbr2 apoptosis inflammation |
| url | https://doi.org/10.1515/med-2021-0222 |
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