New targets of nascent lymphatic vessels in ocular diseases
Recent advancements in the field of endothelial markers of lymphatic vessels and lymphangiogenic factors have shed light on the association between several ocular diseases and ocular nascent lymphatic vessels. The immune privilege of corneal tissue typically limits the formation of lymphatic vessels...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2024.1374627/full |
| _version_ | 1797266455876599808 |
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| author | Xuhui Wu Yunkun Ma Zhaochen Zhang Tingting Hou Yuxi He |
| author_facet | Xuhui Wu Yunkun Ma Zhaochen Zhang Tingting Hou Yuxi He |
| author_sort | Xuhui Wu |
| collection | DOAJ |
| description | Recent advancements in the field of endothelial markers of lymphatic vessels and lymphangiogenic factors have shed light on the association between several ocular diseases and ocular nascent lymphatic vessels. The immune privilege of corneal tissue typically limits the formation of lymphatic vessels in a healthy eye. However, vessels in the eyes can potentially undergo lymphangiogenesis and be conditionally activated. It is evident that nascent lymphatic vessels in the eyes contribute to various ocular pathologies. Conversely, lymphatic vessels are present in the corneal limbus, ciliary body, lacrimal glands, optic nerve sheaths, and extraocular muscles, while a lymphatic vasculature-like system exists in the choroid, that can potentially cause several ocular pathologies. Moreover, numerous studies indicate that many ocular diseases can influence or activate nascent lymphatic vessels, ultimately affecting patient prognosis. By understanding the mechanisms underlying the onset, development, and regression of ocular nascent lymphatic vessels, as well as exploring related research on ocular diseases, this article aims to offer novel perspectives for the treatment of such conditions. |
| first_indexed | 2024-04-25T01:00:58Z |
| format | Article |
| id | doaj.art-dd914ddfcad349058ebe820a153d4043 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-25T01:00:58Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-dd914ddfcad349058ebe820a153d40432024-03-11T04:48:35ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2024-03-011510.3389/fphys.2024.13746271374627New targets of nascent lymphatic vessels in ocular diseasesXuhui Wu0Yunkun Ma1Zhaochen Zhang2Tingting Hou3Yuxi He4The Second Hospital of Jilin University, Changchun, Jilin, ChinaThe Second Hospital of Jilin University, Changchun, Jilin, ChinaThe Second Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Orthopedics, The Second Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Ophthalmology, The Second Hospital of Jilin University, Changchun, Jilin, ChinaRecent advancements in the field of endothelial markers of lymphatic vessels and lymphangiogenic factors have shed light on the association between several ocular diseases and ocular nascent lymphatic vessels. The immune privilege of corneal tissue typically limits the formation of lymphatic vessels in a healthy eye. However, vessels in the eyes can potentially undergo lymphangiogenesis and be conditionally activated. It is evident that nascent lymphatic vessels in the eyes contribute to various ocular pathologies. Conversely, lymphatic vessels are present in the corneal limbus, ciliary body, lacrimal glands, optic nerve sheaths, and extraocular muscles, while a lymphatic vasculature-like system exists in the choroid, that can potentially cause several ocular pathologies. Moreover, numerous studies indicate that many ocular diseases can influence or activate nascent lymphatic vessels, ultimately affecting patient prognosis. By understanding the mechanisms underlying the onset, development, and regression of ocular nascent lymphatic vessels, as well as exploring related research on ocular diseases, this article aims to offer novel perspectives for the treatment of such conditions.https://www.frontiersin.org/articles/10.3389/fphys.2024.1374627/fulllymphangiogenesisocular diseasescorneal immune reactioncorneal (lymph)angiogenic privilegecorneal transplantation immunology |
| spellingShingle | Xuhui Wu Yunkun Ma Zhaochen Zhang Tingting Hou Yuxi He New targets of nascent lymphatic vessels in ocular diseases Frontiers in Physiology lymphangiogenesis ocular diseases corneal immune reaction corneal (lymph)angiogenic privilege corneal transplantation immunology |
| title | New targets of nascent lymphatic vessels in ocular diseases |
| title_full | New targets of nascent lymphatic vessels in ocular diseases |
| title_fullStr | New targets of nascent lymphatic vessels in ocular diseases |
| title_full_unstemmed | New targets of nascent lymphatic vessels in ocular diseases |
| title_short | New targets of nascent lymphatic vessels in ocular diseases |
| title_sort | new targets of nascent lymphatic vessels in ocular diseases |
| topic | lymphangiogenesis ocular diseases corneal immune reaction corneal (lymph)angiogenic privilege corneal transplantation immunology |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2024.1374627/full |
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