Modelling upper respiratory tract diseases: getting grips on host-microbe interactions in chronic rhinosinusitis using in vitro technologies
Abstract Chronic rhinosinusitis (CRS) is a chronic inflammation of the mucosa of the nose and paranasal sinuses affecting approximately 11% of the adult population in Europe. Inadequate immune responses, as well as a dysbiosis of the sinonasal microbiota, have been put forward as aetiological factor...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-04-01
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| Series: | Microbiome |
| Online Access: | http://link.springer.com/article/10.1186/s40168-018-0462-z |
| _version_ | 1819128876955074560 |
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| author | Charlotte De Rudder Marta Calatayud Arroyo Sarah Lebeer Tom Van de Wiele |
| author_facet | Charlotte De Rudder Marta Calatayud Arroyo Sarah Lebeer Tom Van de Wiele |
| author_sort | Charlotte De Rudder |
| collection | DOAJ |
| description | Abstract Chronic rhinosinusitis (CRS) is a chronic inflammation of the mucosa of the nose and paranasal sinuses affecting approximately 11% of the adult population in Europe. Inadequate immune responses, as well as a dysbiosis of the sinonasal microbiota, have been put forward as aetiological factors of the disease. However, despite the prevalence of this disease, there is no consensus on the aetiology and mechanisms of pathogenesis of CRS. Further research requires in vitro models mimicking the healthy and diseased host environment along with the sinonasal microbiota. This review aims to provide an overview of CRS model systems and proposes in vitro modelling strategies to conduct mechanistic research in an ecological framework on the sinonasal microbiota and its interactions with the host in health and CRS. |
| first_indexed | 2024-12-22T08:34:48Z |
| format | Article |
| id | doaj.art-dd92ff08c08e4a9a86eb15c643f2024f |
| institution | Directory Open Access Journal |
| issn | 2049-2618 |
| language | English |
| last_indexed | 2024-12-22T08:34:48Z |
| publishDate | 2018-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Microbiome |
| spelling | doaj.art-dd92ff08c08e4a9a86eb15c643f2024f2022-12-21T18:32:24ZengBMCMicrobiome2049-26182018-04-016111310.1186/s40168-018-0462-zModelling upper respiratory tract diseases: getting grips on host-microbe interactions in chronic rhinosinusitis using in vitro technologiesCharlotte De Rudder0Marta Calatayud Arroyo1Sarah Lebeer2Tom Van de Wiele3Center for Microbial Ecology and Technology, Faculty of Bioscience Engineering, Ghent UniversityCenter for Microbial Ecology and Technology, Faculty of Bioscience Engineering, Ghent UniversityResearch Group of Environmental Ecology and Applied Microbiology, Department of Bioscience Engineering, University of AntwerpCenter for Microbial Ecology and Technology, Faculty of Bioscience Engineering, Ghent UniversityAbstract Chronic rhinosinusitis (CRS) is a chronic inflammation of the mucosa of the nose and paranasal sinuses affecting approximately 11% of the adult population in Europe. Inadequate immune responses, as well as a dysbiosis of the sinonasal microbiota, have been put forward as aetiological factors of the disease. However, despite the prevalence of this disease, there is no consensus on the aetiology and mechanisms of pathogenesis of CRS. Further research requires in vitro models mimicking the healthy and diseased host environment along with the sinonasal microbiota. This review aims to provide an overview of CRS model systems and proposes in vitro modelling strategies to conduct mechanistic research in an ecological framework on the sinonasal microbiota and its interactions with the host in health and CRS.http://link.springer.com/article/10.1186/s40168-018-0462-z |
| spellingShingle | Charlotte De Rudder Marta Calatayud Arroyo Sarah Lebeer Tom Van de Wiele Modelling upper respiratory tract diseases: getting grips on host-microbe interactions in chronic rhinosinusitis using in vitro technologies Microbiome |
| title | Modelling upper respiratory tract diseases: getting grips on host-microbe interactions in chronic rhinosinusitis using in vitro technologies |
| title_full | Modelling upper respiratory tract diseases: getting grips on host-microbe interactions in chronic rhinosinusitis using in vitro technologies |
| title_fullStr | Modelling upper respiratory tract diseases: getting grips on host-microbe interactions in chronic rhinosinusitis using in vitro technologies |
| title_full_unstemmed | Modelling upper respiratory tract diseases: getting grips on host-microbe interactions in chronic rhinosinusitis using in vitro technologies |
| title_short | Modelling upper respiratory tract diseases: getting grips on host-microbe interactions in chronic rhinosinusitis using in vitro technologies |
| title_sort | modelling upper respiratory tract diseases getting grips on host microbe interactions in chronic rhinosinusitis using in vitro technologies |
| url | http://link.springer.com/article/10.1186/s40168-018-0462-z |
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